cancer Cancer Discovery Cancer screening

Spread of Deadly Eye Cancer Halted in Cells and Animals

 By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn’t spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. Their experiments suggest that blocking part of the chain of events — which they successfully accomplished in zebra fish and human cells — stops the growth and spread of the eye tumor cells.
Biotechnology

Researchers Find Potential New Gene Therapy for Blinding Disease

Scientists funded by NIH preserve vision in dogs with a disease similar to retinitis pigmentosa in humans. Scientists funded by the National Eye Institute (NEI) report a novel gene therapy that halts vision loss in a canine model of a blinding condition called autosomal dominant retinitis pigmentosa (adRP). The strategy could one day be used to slow or prevent vision loss in people with the disease. NEI is part of
Gene Therapy

Study advances gene therapy for glaucoma

While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains to control fluid pressure in the eye. Genes can't work until they enter a cell. Glaucoma, one of the most common blinding diseases, is caused by excess pressure inside the eye, usually due to a clog
Ophthalmology

NIH Discovery Brings Stem Cell Therapy for Eye Disease Closer to the Clinic

Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE)—a layer of cells in the back of the eye—are essential for the survival of the retina’s light-sensing photoreceptors. The discovery has advanced efforts to make stem cell-derived RPE for transplantation into patients with geographic atrophy, otherwise known as dry age-related
Diabetes

Scientists Find Therapeutic Target for Diabetes-Related Blindness

Study reveals single cell type and surface molecule sufficient to cause common complication Specific cells in the retina trigger inflammation and vision impairment associated with diabetes, according to new research out of Case Western Reserve University School of Medicine. The findings unexpectedly implicate Müller cells—which provide structural support in the retina—as key drivers of the process. Researchers now have a therapeutic target in hand and understand initial steps of diabetic
Biotechnology

In-Home Occupational Therapy Curbs Depression in Visually Impaired Patients

Depression is common in patients with central vision loss, but study suggests that low vision rehabilitation and occupational therapy could decrease its severity Johns Hopkins researchers report that in-home occupational therapy appears to reduce the rate and severity of depression in people at higher risk for the disorder because of seriously impaired vision. The Centers for Disease Control and Prevention says older adults in the United States are already at
Biotechnology

Researchers Develop Best-Yet Cell Culture System for Age-Related Macular Degeneration

An international team from the University of Alabama at Birmingham and University College London and Queens University Belfast in the United Kingdom developed a cell culture model that could help to develop earlier treatment strategies for age-related macular degeneration, the third most prevalent cause of vision loss worldwide. In AMD, which is twice as prevalent in older persons as Alzheimer’s disease, the part of the retina used for detailed vision
Ophthalmology

Saving Sight In Glaucoma: Why The Brain May Hold The Key

What causes vision loss in glaucoma? There are two common answers that at first may seem disparate: the first is pressure, as in elevated ocular pressure, and the second is damage to the optic nerve, which is the structure that sends visual information to the brain. Both answers are correct. Glaucoma involves sensitivity to ocular pressure (not just elevated pressure) that is translated or transduced to stress that degrades the
Uncategorized

Simple Procedure Could Improve Treatment for Common Eye Disease

A new, minimally invasive procedure appears to be effective for many patients with Fuchs endothelial dystrophy (FED), a common eye disease, without the potential side effects and cost of the current standard of care, a cornea transplant. In a proof-of-concept study, published in the journal Cornea, researchers led by Kathryn Colby, MD, PhD, the Louis Block professor and chairman of the Department of Ophthalmology and Visual Science at the University
Uncategorized

Visual Impairment, Blindness Cases in U.S. Expected to Double by 2050

With the youngest of the baby boomers hitting 65 by 2029, the number of people with visual impairment or blindness in the United States is expected to double to more than 8 million by 2050, according to projections based on the most recent census data and from studies funded by the National Eye Institute, part of the National Institutes of Health. Another 16.4 million Americans are expected to have difficulty
Biotechnology Cell Therapy

First Skin-to-Eye Stem Cell Transplant in Humans Successful

Researchers have safely transplanted stem cells derived from a patient’s skin to the back of the eye in an effort to restore vision. The research is being presented at the 2016 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Seattle, Wash. A small piece of skin from the patient’s arm was collected and modified into induced pluripotent stem cells (iPSC). The iPSCs were