Biotechnology cancer

Wistar scientists develop novel immunotherapy technology for prostate cancer

A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific protein. This is the first application of the new technology, called DNA-encoded monoclonal antibody (DMAb), for cancer immunotherapy. The study […]

Immunotherapies Vaccines

Experimental HIV vaccine regimen is well-tolerated, elicits immune responses

Results from an early-stage clinical trial called APPROACH show that an investigational HIV vaccine regimen was well-tolerated and generated immune responses against HIV in healthy adults. The APPROACH findings, as well as results expected in late 2017 from another early-stage clinical trial called TRAVERSE, will form the basis of the decision whether to move forward […]

Biotechnology cancer Vaccines

Immunotherapy with DNA vaccine shows promise for HPV-related head and neck cancer

A novel vaccine therapy can generate immune responses in patients with head and neck squamous cell carcinoma (HNSCCa), according to researchers at the Abramson Cancer Center of the University of Pennsylvania. The treatment specifically targets human papillomavirus (HPV), which is frequently associated with HNSCCa, to trigger the immune response. Researchers will present the results of […]

Vaccines

GeoVax to Collaborate with Georgia State on Development of Hepatitis B Therapeutic Vaccine

The Georgia State University Research Foundation has entered into a research collaboration agreement with GeoVax Labs, Inc., a Georgia-based biotechnology company developing human vaccines, to advance development of a therapeutic vaccine for treatment of chronic Hepatitis B infections. The Centers for Disease Control and Prevention estimates between 700,000 to 1.4 million people in the United […]

Biotechnology cancer Clinical Trials

Moffitt Cancer Center Researchers Report Promising Clinical Activity and Minimal Toxicities for HER2-Targeted Dendritic Cell Vaccines in Early-Stage Breast Cancer Patients

HER2-Targeted Dendritic Cell Vaccines Stimulate Immune Responses and Regression of HER2-Expressing Early-Stage Breast Tumors Deregulation and inhibition of the immune system contributes to cancer development. Many therapeutic strategies aim to restimulate the immune system to recognize cancer cells and target them for destruction. Researchers from Moffitt Cancer Center report that a dendritic cell vaccine that […]

Vaccines

Neurodevelopmental Model Of Zika May Provide Rapid Answers

A newly published study from researchers working in collaboration with the Regenerative Bioscience Center at the University of Georgia demonstrates fetal death and brain damage in early chick embryos similar to microcephaly—a rare birth defect linked to the Zika virus, now alarming health experts worldwide. The team, led by Forrest Goodfellow, a graduate student in […]

cancer Cancer Discovery

Q&A with Heat Biologics’ Founder and CEO Jeffrey Wolf on T Cell Stimulating Cancer Immunotherapies

Immuno-oncology, a field of fast advancing science that activates a patient’s own immune system against cancer, holds great promise.  A number of companies in the field are developing treatment platforms, many of which are patient-specific (autologous) and therefore costly. Heat Biologics’ ImPACT (Immune Pan-Antigen Cytotoxic Therapy) is fully allogeneic, off-the-shelf and cost-efficient, offering the potential […]

cancer Cancer Discovery

New anti-cancer strategy mobilizes both innate and adaptive immune response

Though a variety of immunotherapy-based strategies are being used against cancer, they are often hindered by the inability of the immune response to enter the immunosuppressive tumor microenvironment and to effectively mount a response to cancer cells. Now, scientists from the RIKEN Center for Integrative Medical Sciences have developed a new vaccine that involves injecting […]