Type 1 diabetes Archives – The Bio Connection

Diabetes

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018January 17, 2018 TheBioConnection Comment(0)

Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it. The TEDDY study’s international research team has identified the new gene regions in young people […]

Diabetes

Pain-Free Skin Patch Responds to Sugar Levels for Management of Type 2 Diabetes

December 26, 2017February 26, 2018 TheBioConnection Comment(0)

Researchers with NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB) have devised an innovative biochemical formula of mineralized compounds that interacts in the bloodstream to regulate blood sugar for days at a time. In a proof-of-concept study performed with mice, the researchers showed that the biochemically formulated patch of dissolvable microneedles can respond to […]

Biotechnology Diabetes

Sernova Tackles both Diabetes and Hemophilia with one Technology

July 25, 2016May 12, 2017 TheBioConnection Comment(0)

contributed by Richard (Rick) Mills Editor, Ahead of the Herd As a general rule, the most successful man in life is the man who has the best information. Paul Lacey was a researcher at Washington University when, in 1972, he cured some diabetic rats by transplanting the islet cells from healthy rats into diabetic ones. […]

Diabetes

Joint Research Collaboration Aims to Advance Human Clinical Trials for the Treatment of Hypoglycemic Unawareness Patients with Severe Type 1 Diabetes

July 14, 2016July 13, 2016 TheBioConnection Comment(0)

A new research funding agreement between the Juvenile Diabetes Research Foundation (JDRF) and Sernova, a clinical-stage regenerative medicine biotech, aims to address people with severe type 1 diabetes (T1D) who are hypoglycemia unaware, a condition in which a person with diabetes does not experience the usual early warning symptoms of hypoglycemia (low blood sugar) following […]

Cell Therapy

Stem Cells From Diabetic Patients Coaxed to Become Insulin-Secreting Cells

May 13, 2016May 12, 2016 TheBioConnection Comment(0)

Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St. Louis and Harvard University have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes. People with this form of diabetes can’t make their own insulin and require regular insulin injections to control their blood […]

Biotechnology Diabetes

Solving a Genetic Mystery in Type 1 Diabetes

April 11, 2016April 11, 2016 TheBioConnection Comment(0)

In type 1 diabetes, the immune system attacks the body’s own insulin-producing cells. Scientists understand reasonably well how this autoimmune attack progresses, but they don’t understand what triggers the attack or how to stop it, says Stephan Kissler, Ph.D., Investigator in the Section on Immunobiology at Joslin Diabetes Center and Assistant Professor of Medicine at […]

The cause of prostate cancer progression to incurable stage has likely been uncovered July 20, 2018
Researchers have discovered novel genes and mechanisms that can explain how a genomic variant in a single nucleotide polymorphism (SNP) rs11672691 influences prostate cancer aggressiveness. Their findings also suggest ways to improve risk stratification and clinical treatment for advanced prostate cancer.
Diabetes raises risk of cancer, with women at even greater likelihood, a major new study has found July 19, 2018
A global review involving almost 20 million people has shown that having diabetes significantly raises the risk of developing cancer, and for women the risk is even higher. Researchers also found diabetes (type 1 and type 2) conferred an additional risk for women, compared to men, for leukaemia and cancers of the stomach, mouth and […]
Genome damage from CRISPR/Cas9 gene editing higher than thought July 19, 2018
Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. This has safety implications for future gene therapies using CRISPR/Cas9 as the unexpected damage could lead to dangerous changes in some cells. The study revealed that standard DNA tests miss finding this genetic damage, and that caution […]
Discovery of kidney cancer driver could lead to new treatment strategy July 19, 2018
Researchers suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.
Why does making new egg cells require so much cell death? July 19, 2018
A highly detailed study of how the roundworm C. elegans forms oocytes suggests that the egg-making process leads to the formation and subsequent destruction of cells with an extra nucleus, but that some cellular materials are recycled into new eggs.
Low- or no-calorie soft drinks linked to improved outcomes in colon cancer July 19, 2018
Drinking artificially-sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and cancer death, scientists have found.
Complementary medicine for cancer can decrease survival July 19, 2018
People who received complementary therapy for curable cancers were more likely to refuse at least one component of their conventional cancer treatment, and were more likely to die as a result, according to researchers.
Targeting headaches and tumors with nano-submarines July 19, 2018
Scientists have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors.
High fruit and vegetable consumption may reduce risk of breast cancer July 19, 2018
Women who eat a high amount of fruits and vegetables each day may have a lower risk of breast cancer, especially of aggressive tumors, than those who eat fewer fruits and vegetables, according to a new study.
Sunscreen reduces melanoma risk by 40 per cent in young people July 19, 2018
A world-first study has found that Australians aged 18-40 years who were regular users of sunscreen in childhood reduced their risk of developing melanoma by 40 percent, compared to those who rarely used sunscreen.

Callitas Health banks on CannaStrips and OTC products while swinging for the fence with blockbuster drugs July 20, 2018
CannaStrips will generate near-term revenue, while the company’s blue-sky pharmaceutical assets and orphan drug are solid, long-term plays
AcuityBio developing 'breakthrough' implant treatment for lung cancer July 20, 2018
AcuityBio Corp CEO Dr. John Schwartz tells Proactive Investors the biotech is developing an implant called ABC-103 that prevents post-surgical lung cancer occurrence. Dr. Schwartz says ABC-103 is in the last stages of product development, and the company is pursuing Phase 1 clinical trials.
PureTech Health surges as it hooks up with Swiss drugs giant Roche July 20, 2018
PureTech Health has been advancing internal R&D projects that focus on the brain-immune-gut axis, with an emphasis on lymphatics and immune cell trafficking to modulate immunity in a tissue-specific manner.
AorTech International looking to the future July 20, 2018
The company is now fully funded to implement its new business plan
Intuitive Surgical shares pop on robust 2Q earnings due to booming sales of its robotic surgery systems July 19, 2018
The company’s success stemmed from a jump in the sale of its da Vinci surgical systems, which provide robotic assistance to surgeons
Canntab Therapeutics building cannabis delivery facility with FSD Pharma July 19, 2018
Canntab Therapeutics Ltd (CSE:PILL) CEO Jeff Renwick and CFO Richard Goldstein tell Proactive Investor's Christine Corrado the cannabis delivery manufacturing company is lining up its ducks ahead of the legalization of cannabis in Canada on October 17 this year - as it announced a profit sharing collaboration with medical pot producer FSD Pharma Inc. Canntab […]
Mersana Therapeutics shares plummet after FDA puts partial hold on key cancer drug trial July 19, 2018
No new patients will be enrolled in the Phase 1 study of the cancer drug XMT-1522 after the death of a participant
Pressure BioSciences developing breakthrough processing method for shelf-stable milk, dairy products July 19, 2018
The Massachusetts company’s high-pressure Ultra Shear Technology will play a significant role in the preservation of 'clean label' foods and beverages
Optibiotix is a very clever business model says chairman July 19, 2018
Optibiotix PLC (LON:OPTI) is a very clever business model says chairman Neil Davidson, who just bought a sizeable chunk of additional shares in the microbiome-based additives business. Recent licensing agreements will turn into revenue streams later this year and the business will go from strength to strength, he believes. The key is to get Optibiotix’s […]
ValiRx Plc enjoying strong industry interest in its cancer treatments July 19, 2018
George Morris, chief operations officer at ValiRx Plc (LON:VAL), updates Proactive's Andrew Scott on developments across the company's portfolio. Morris says advanced conversations are continuing with possible partners as they look to press ahead with the development of their flagship VAL401 lung cancer candidate.

STAT Plus: A federal appeals court just slammed the door on Allergan’s deal with the Mohawk tribe July 20, 2018
The drug maker Allergan tried to transfer rights to one of its medicines to a Native American tribe to avoid a patent challenge. An appeals court said the move could…
Up and Down the Ladder: The latest comings and goings July 20, 2018
Send us your changes, and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going.
Pharmalittle: Trump officials urge drug makers to lower prices; Drug dealers are sued for creating opioid crisis July 20, 2018
Pharmalittle: Your daily rundown of all things pharma, by @edsilverman
Merck joins the list of drug makers agreeing to freeze or lower some prices July 19, 2018
“It’s as clear as the drug pricing system is clear,” Dr. Walid Gellad said about vows to halt price hikes.
STAT Plus: Allergan trial results for a new eye treatment are underwhelming to Wall Street July 19, 2018
Clinical trial results for an experimental eye treatment that would compete in a lucrative market made an underwhelming impression on Wall Street.
STAT Plus: Pharmalittle: Gilead and Lousiana eye a ‘Netflix’ model; Trump thanks Novartis for price freeze July 19, 2018
President Trump tweeted a thank you to Novartis (NVS) for joining Pfizer (PFE) in agreeing not to raise prices.
STAT Plus: Pharmalittle: CVS and Ohio battle over Medicaid data; AbbVie strikes another Humira biosimilar deal July 18, 2018
CVS Caremark is suing the Ohio Medicaid to block release of a report detailing how the PBM charged taxpayers up six times as much to process prescription drugs as the…
Novartis hits the brakes on price hikes as political pressure builds July 18, 2018
The decision to forestall further price increases also comes at a highly delicate time for the company: renewed attention to its deal with Trump lawyer Michael Cohen.
STAT Plus: FDA eyes new ways to lower some drug costs and boost consumer access July 17, 2018
The guidance, which the agency called a “first step,” is designed to encourage drug makers to think about ways to seek approval for over-the-counter approvals.
STAT Plus: Health Canada is ordered to provide clinical trial data on several medicines to a researcher July 17, 2018
This was the first case to test Vanessa’s Law, passed after a 15-year-old died of a heart attack after taking a heartburn drug whose risks were insufficiently communicated.

U.S. FDA Approves Pfizer’s Biosimilar NIVESTYM™ (filgrastim-aafi)
NIVESTYM™, a biosimilar to Neupogen® (filgrastim), is Pfizer’s fourth biosimilar to be approved by the FDA.
PureTech Health and Roche Sign Collaboration Deal Worth $1 Billion-Plus
Boston-based PureTech Health inked a multi-year collaboration deal with Swiss-based Roche to advance PureTech’s milk-derived exosome platform technology for oral dosing of Roche’s antisense oligonucleotide platform.
Sage Bionetworks Launches the Agora Platform Making Curated Genomic Analysis of Alzheimer’s Disease Widely Available
Sage Bionetworks announces the launch of the Agora platform (agora.ampadportal.org) an interactive, web-based tool that allows researchers to explore curated genomic analyses of Alzheimer’s Disease (AD), including a list of early candidate target nominations for AD.
Agios Pharmaceuticals Scores FDA Approval For Tibsovo, Second AML Drug Win in Less Than a Year
Shares of Agios Pharmaceuticals jumped this morning after the company said the FDA approved its oral leukemia treatment Tibsovo (ivosidenib). It’s the second approval for the company in less than a year.
Rumor Alert: Merck KGaA to Buy Madrigal and Roche to Acquire Tesaro?
Investors love their takeover rumors, and with biopharma having a good year for mergers and acquisitions, there’s been plenty to keep them busy. Here’s two takeover rumors that came out of Spanish media group Intereconomia.
Report: New Jersey Heating Up for Biopharma Incubators and Innovation Spaces
The Institute for Life Science Entrepreneurship (ILSE) released a white paper highlighting life science incubator space and innovation trends in New Jersey. The report, entitled “Recent Advances in Laboratory and Innovation Space in New Jersey” profiles these efforts.
Koutif Therapeutics Confirms Clinical Candidate Drug
Company Expects to File IND Application in Late 2018.
Karius Liquid Biopsy Accurately Detects Invasive Fungal Infections
Some diagnostics testing for infectious diseases can be quite invasive and uncomfortable for a patient. Now though, a new form of test is available that can mitigate the need for those invasive tests.
Highlights from Lilly's Alzheimer's Disease Pipeline at the Alzheimer's Association International Conference® 2018 (AAIC® 2018)
Eli Lilly and Company (NYSE: LLY) today announced that new results from a number of studies across the company's Alzheimer's disease pipeline will be presented at the Alzheimer's Association International Conference (AAIC) in Chicago, July 22-26, 2018. Nearly 30 oral and poster presentations will underscore Lilly's focus on making a meaningful difference in the lives […]
July 20 Research Roundup: PARPi and Rare Cancers, “Pleasure” Brain Chemicals and Cancer Suppressi...
There are plenty of great scientific research stories out this week. Here’s a look at just a few of them.