Connecting You to Tomorrow's Biotechnology Innovations
Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. But the study, which will be published May 4 in the Journal of Experimental Medicine, reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents […]
Researchers find novel combination disrupts multiple factors in aggressive type of cancer In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death. Triple-negative breast cancer is a subtype that does not […]
Researchers in China have discovered that a metabolic enzyme called AKR1B1 drives an aggressive type of breast cancer. The study, “AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program,” which has been published in The Journal of Experimental Medicine, suggests that an inhibitor of this enzyme currently used […]
Meeting focuses on state-of-the-art breast cancer research, including immunotherapeutic approaches A researcher from University Hospitals Seidman Cancer Center discussed his upcoming immunotherapy clinical trial for triple-negative breast cancer at the 2016 San Antonio Breast Cancer Symposium. The annual symposium is the premier meeting for more than 7,500 physicians and scientists dedicated to breast cancer treatment, […]
A team of scientists from the National University of Singapore (NUS) has established novel insights into the relationship between breast cancer tumour intracellular redox environment and the cancer cells’ ability to become invasive. The study by Dr Alan Prem Kumar from the Cancer Science Institute of Singapore (CSI Singapore) at NUS and NUS Yong Loo […]
Drugs that target and destroy phosphorylated-p68 (P-p68), an RNA helicase, have the potential to kill cancer, without damaging other tissues as chemotherapy does. P-p68 has recently garnered attention as a molecular target in cancer therapy. It is an ideal target because P-p68 is overexpressed in cancer cells but absent in normal cells. P-p68 has shown […]
While we look to invent new medicines to treat cancer, a parallel approach to repurpose existing medicines may be highly effective. Stress, mediated by adrenaline, has been suspected to promote cancer growth and this research study shows that by blocking adrenaline receptors in breast cancers, they are less successful in spreading to and growing in […]