Biotechnology

Next step towards replacement therapy in type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. This breakthrough published in the journal Nature will facilitate the manufacturing of pancreatic islet cells from stem cells and might help combating type 1 diabetes. Prof. Dr. Henrik Semb who led the study recently joined Helmholtz
stem cells

Platelets grown from stem cells may be alternative to donated platelets

Researchers have developed a way to grow human platelets in the laboratory from stem cells derived from fat tissue. The achievement, reported today in the journal Blood, suggests manufactured platelets could eventually reduce the reliance on donated platelets to help patients with cancer and other disorders. Platelets are a component of blood that helps with clotting. Platelet transfusions can be life-saving for patients dealing with cancer or the effects of chemotherapy, infections,
cancer Cancer Discovery

Discovery of Pathway Leading to Growth of Colon Cancer Stem Cells Could Lead to New Possibilities in Colorectal Cancer Treatment

In a discovery that may have significant impact on the future of colon cancer treatment and research, scientists at the Helen F. Graham Cancer & Research Institute’s Center for Translational Cancer Research at Christiana Care Health System have defined a key signaling pathway that regulates colon cancer growth. Wilmington, Delaware, Oct. 11, 2018 – In a discovery that may have significant impact on the future of colon cancer treatment and research, scientists at the Helen F. Graham Cancer & Research
Biotechnology Regenerative Medice stem cells

New Technique Uses Umbilical Cord Stem Cells for Early Repair of Cleft Palate

A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.  Performed as part of reconstructive surgery when the infant is a few months old, the stem cell procedure provides good results in growing new bone to close the upper jaw cleft – and may avoid the need for later bone graft surgery, according to the case report by Alejandro Garcia Botero, MD, of Hospital
Biotechnology

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as
Breast Cancer cancer Cancer Discovery Clinical Trials

Researchers to Test Novel Drug Combination Against Toughest Breast Cancers

Phase I clinical trial will combine standard chemotherapy with cirmtuzumab, a drug that has shown promise against a variety of cancer types Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed. Cirmtuzumab is a novel monoclonal antibody
stem cells

UIC Researchers Create Heart Cells to Study AFib

University of Illinois at Chicago researchers have discovered a way turn pluripotent stem cells into atrial cells, which make up the upper chambers, or atria, of the heart. The discovery will enable them to better study atrial fibrillation, the most common heart rhythm disorder also known as AFib, which originates in the heart’s atria. As reported in the journal Stem Cell Reports, the researchers obtained blood cells from healthy volunteers, activated genes to
stem cells

Stem Cell Therapy May Help Reverse Effects of Premature Menopause, Restore Fertility

Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in Chicago, Ill. "In the two participants who have completed the treatment to date, serum estrogen
Arthritis Cell Therapy Clinical Trials

Small molecule could make a big difference for arthritis patients

Will there come a time when a patient with arthritis can forgo joint replacement surgery in favor of a shot? Keck School of Medicine of USC scientist Denis Evseenko, MD, PhD, has reason to be optimistic. In a new publication in the Annals of Rheumatic Diseases, Evseenko's team describes the promise of a new molecule aptly named "Regulator of Cartilage Growth and Differentiation," or RCGD 423 for short. As its
stem cells

‘Decorated’ Stem Cells Could Offer Targeted Heart Repair

Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury – and getting them to stay there – remains challenging. In a new pilot study using an animal model, North Carolina State University researcher Ke Cheng and his team show that “decorating” cardiac stem cells with platelet nanovesicles can increase the stem cells’ ability to find and remain
Biotechnology Neurology Neuroscience Uncategorized

Better ‘Mini Brains’ Could Help Scientists Identify Treatments for Zika-Related Brain Damage

UCLA researchers develop improved technique for creating brain tissue from stem cells UCLA researchers have developed an improved technique for creating simplified human brain tissue from stem cells. Because these so-called “mini brain organoids” mimic human brains in how they grow and develop, they’re vital to studying complex neurological diseases. In a study published in the journal Cell Reports, the researchers used the organoids to better understand how Zika infects and
stem cells

Prostaglandin E1 Inhibits Leukemia Stem Cells Targeting leukemia stem cells in combination with standard chemotherapy may improve treatment for chronic myeloid leukemia

Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice. CML is a relatively common cancer. The American Cancer Society estimates that in 2017 there will be about 8,950 new cases and about 1,080 people will die of the disease. In its
stem cells

Fetal membranes may help transform regenerative medicine

A new review looks at the potential of fetal membranes, which make up the amniotic sac surrounding the fetus during pregnancy, for regenerative medicine. Fetal membranes have been used as biological bandages for skin grafts as well as for serious burns. They may also have numerous other applications because they contain a variety of stem cells, which might be used to treat cardiovascular and neurological diseases, diabetes, and other medical
Biotechnology Cell Therapy Clinical Trials rare diseases stem cells

CRI Scientists Discover Vitamin C Regulates Stem Cell Function and Suppresses Leukemia Development

Not much is known about stem cell metabolism, but a new study from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia. “We have known for a while that people with lower levels of ascorbate (vitamin C) are at increased cancer risk, but we haven’t fully
age-related decline Cell Therapy stem cells

Stem Cells May Be The Key To Staying Strong In Old Age

University of Rochester Medical Center researchers have discovered that loss of muscle stem cells is the main driving force behind muscle decline in old age in mice. Their finding challenges the current prevailing theory that age-related muscle decline is primarily caused by loss of motor neurons. Study authors hope to develop a drug or therapy that can slow muscle stem cell loss and muscle decline in the future. As early
Biotechnology

Stem Cell Trial for Stroke Patients Suffering Chronic Motor Deficits Begins at UTHealth

A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). McGovern Medical School at UTHealth is the only site in Texas and the central south portion of the country to open enrollment for the multi-institutional, phase
Biotechnology Uncategorized

UW Scientists Find Key Cues to Regulate Bone-Building Cells

The prospect of regenerating bone lost to cancer or trauma is a step closer to the clinic as University of Wisconsin-Madison scientists have identified two proteins found in bone marrow as key regulators of the master cells responsible for making new bone. In a study published online today (Feb. 2, 2017) in the journal Stem Cell Reports, a team of UW-Madison scientists reports that the proteins govern the activity of
Biotechnology Cell Therapy

New stem cell delivery approach regenerates dental pulp-like tissue in a rodent model

When a tooth is damaged, either by severe decay or trauma, the living tissues that comprise the sensitive inner dental pulp become exposed and vulnerable to harmful bacteria. Once infection takes hold, few treatment options--primarily root canals or tooth extraction--are available to alleviate the painful symptoms. Researchers at Tufts University School of Dental Medicine (TUSDM) now show that using a collagen-based biomaterial to deliver stem cells inside damaged teeth can
Biotechnology Cell Therapy

Leading Cell Therapy Company Pluristem to Partner with Japan’s Sosei for Commercialization of Regenerative Medicines in Japan

In a major global regenerative medicine deal, Israel-based Pluristem Therapeutics and Japan’s Sosei CVC, the venture capital arm of Japanese biopharma company Sosei Group, agreed to form a joint venture (JV) to commercialize Pluristem’s PLX-PAD cells in Japan. The deal marks Pluristem’s commercial entry into Japan and expands Sosei’s pipeline into regenerative medicines. Pluristem has been active in the Japan market through discussions with, and applications to, Japan’s health regulatory
Biotechnology rare diseases

Stem Cell-Based Test Predicts Leukemia Patients’ Response to Therapy to Help Tailor Treatment

Newswise — (TORONTO, Canada – Dec. 7, 2016) – Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment. The findings, published online today in Nature, could potentially transform patient care in AML by giving clinicians a risk scoring tool that within a day or two