Biotechnology Cell Therapy stem cells

Stem Cell Signal Drives New Bone Building

In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building. If harnessed in humans, they say, the protein — known as WISP-1 — could help fractures heal faster, speed surgical recovery and possibly prevent bone loss due to aging, injury
Cell Therapy

Stem Cell-Derived Neurons Stop Seizures and Improve Cognitive Function

About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs. Even when the drugs do work, people may develop cognitive and memory problems and depression, likely from the combination of the underlying seizure disorder and the drugs to treat it. A team
Biotechnology Cell Therapy

New Cell Therapy Aids Heart Recovery—Without Implanting Cells

Columbia biomedical engineers invent innovative technique to help injured hearts regenerate, through therapeutic application of extracellular vesicles secreted by cardiomyocytes derived from human pluripotent stem cells Heart disease is a major global health problem--myocardial infarction annually affects more than one million people in the U.S. alone, and there is still no effective treatment. The adult human heart cannot regenerate itself after injury, and the death of cardiac muscle cells, known
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New Stem-Cell Based Stroke Treatment Repairs Damaged Brain Tissue

A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research. The research team led by UGA professor Steven Stice and Nasrul Hoda of Augusta University created a treatment called AB126
Biotechnology Cell Therapy Clinical Trials

A Protein Could Make Stem Cell Therapy for Heart Attack Damage More Effective

Researchers may have found a way to reduce ongoing heart damage that occurs long after a severe heart attack by improving the longevity of stem cells injected into the heart. The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the disease. “The research could eventually make stem-cell therapy a more viable option for treating long-term
Biotechnology Cell Therapy Clinical Trials stem cells

UCLA Researchers Create Skeletal Muscle From Stem Cells

Discovery is major step towards a stem cell replacement therapy for Duchenne Muscular Dystrophy UCLA scientists have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells, which can produce all cell types of the body. The findings are a major step towards developing a stem cell replacement therapy for muscle diseases including Duchenne Muscular Dystrophy, which affects approximately 1 in
Biotechnology Cell Therapy Clinical Trials Infectious Diseases stem cells

Finding a Key to Unlock Blocked Differentiation in Microrna-Deficient Embryonic Stem Cells

This aids goal to use stem cells in therapy, where an important hurdle is efficient differentiation. The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to all those different cell fates. One very active area of biology is cells that mimic
Biotechnology Cell Therapy stem cells

Scientists create stem cell therapy for lung fibrosis conditions

A team of scientists from the UNC School of Medicine and North Carolina State University (NCSU) has developed promising research towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis -- often-fatal conditions that affect tens of millions of Americans. In the journal Respiratory Research, the scientists demonstrated that they could harvest lung stem cells from
Biotechnology Cell Therapy rare diseases

Cardiac stem cells from heart disease patients may be harmful

Patients with severe and end-stage heart failure have few treatment options available to them apart from transplants and "miraculous" stem cell therapy. But a new Tel Aviv University study finds that stem cell therapy may, in fact, harm heart disease patients. The research, led by Prof. Jonathan Leor of TAU's Sackler Faculty of Medicine and Sheba Medical Center and conducted by TAU's Dr. Nili Naftali-Shani, explores the current practice of
Biotechnology

Stem Cell Treatment May Restore Vision to Patients with Damaged Corneas

Researchers working as part of the University of Georgia’s Regenerative Bioscience Center have developed a new way to identify and sort stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient’s own eye tissue. They published their findings in Biophysical Journal. The cornea is a transparent layer of tissue covering the front of the eye, and its health is maintained by
Biotechnology Uncategorized

Tissue Engineering Advance Reduces Heart Failure in Model of Heart Attack

Researchers have grown heart tissue by seeding a mix of human cells onto a 1-micron-resolution scaffold made with a 3-D printer. The cells organized themselves in the scaffold to create engineered heart tissue that beats synchronously in culture. When the human-derived heart muscle patch was surgically placed onto a mouse heart after a heart attack, it significantly improved heart function and decreased the amount of dead heart tissue. “Our novel
Cardiology Cell Therapy

Synthetic Stem Cells Could Offer Therapeutic Benefits, Reduced Risks

Researchers from North Carolina State University, the University of North Carolina at Chapel Hill and First Affiliated Hospital of Zhengzhou University have developed a synthetic version of a cardiac stem cell. These synthetic stem cells offer therapeutic benefits comparable to those from natural stem cells and could reduce some of the risks associated with stem cell therapies. Additionally, these cells have better preservation stability and the technology is generalizable to
Biotechnology Cell Therapy

Rare Obesity Syndrome Therapeutic Target Identified

Columbia University Medical Center (CUMC) researchers have discovered that a deficiency of the enzyme prohormone covertase (PC1) in the brain is linked to most of the neuro-hormonal abnormalities in Prader-Willi syndrome, a genetic condition that causes extreme hunger and severe obesity beginning in childhood. The discovery provides insight into the molecular mechanisms underlying the syndrome and highlights a novel target for drug therapy. The findings were published online today in
Biotechnology Clinical Trials Ophthalmology

JCyte Completes Enrollment For Phase I/IIa Safety Trial

Company is poised to begin phase IIb efficacy trial in 2017 California-based regenerative medicine company jCyte has completed enrollment in a phase I/IIa trial to study the safety of its stem cell therapy candidate for retinitis pigmentosa (RP). The trial included 28 patients with advanced RP, eight of whom have completed the one-year study. Early safety results have been promising. “We have successfully completed four DSMB (Data Safety Monitoring Board)
Cell Therapy

Breakthrough in Understanding How Stem Cells Become Specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. A study published today in Molecular Cell shows that a protein called OCT4 narrows down the range of cell types that stem cells can become. The findings could impact efforts to produce specific types of cells
cancer Cancer Discovery Cell Therapy Gene Therapy Genomes

Four NCI Cancer Centers Announce Landmark Research Consortium and Collaborations with Celgene

The Abramson Cancer Center at the University of Pennsylvania, The Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, and The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai announced the establishment of a research consortium focused on accelerating the discovery and development of novel cancer therapeutics and diagnostics for the benefit of patients. The consortium