Immunotherapies

Scientists Identify a Protein Complex That Shapes the Destiny of T Cells

Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, St. Jude Children’s Research Hospital scientists have reported. The research appears today in the journal Science Immunology and adds to growing evidence of the critical role cell metabolism plays in the immune system. The protein complex is mTORC1, which regulates cell growth and metabolism. St. Jude immunologists found mTORC1 acts
Diabetes

Stealth Pig Cells May Hold The Key To Treating Diabetes In Humans

University of Alabama at Birmingham researchers are exploring ways to wrap pig tissue with a protective coating to ultimately fight diabetes in humans. The nano-thin bilayers of protective material are meant to deter or prevent immune rejection. The ultimate goal: transplant insulin-producing cell-clusters from pigs into humans to treat Type 1 diabetes. In preclinical work begun this year, these stealth insulin-producers — pancreatic islets from pigs or mice coated with