Environmental Health

Mixed chemicals in beauty products may harm women’s hormones

As we go about our daily lives, we are exposed to many different chemicals that could have negative effects on our hormones. These hormonal changes have been linked to several adverse health outcomes such as breast cancer and cardiovascular disease. Therefore, understanding chemicals that influence hormone levels is important for public health--and particularly for women's health--since their exposure to these chemicals is often higher due to their presence in beauty
Infection Control

Penn Study Reveals New Therapeutic Target for Slowing the Spread of Flu Virus

Researchers show altering the molecular interactions between the flu virus and host genes stunts virus replication Influenza A (flu A) hijacks host proteins for viral RNA splicing and blocking these interactions caused replication of the virus to slow, according to new research published in Nature Communications by Kristin W. Lynch, PhD, chair of the department of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, and
Cancer Discovery

Research discovers how some cancers resist treatment

An international team of researchers led by Lucio Miele, MD, PhD, Professor and Chair of Genetics at LSU Health New Orleans School of Medicine, and Justin Stebbing, BM BCh MA, PhD, Professor of Cancer Medicine and Medical Oncology at Imperial College of Medicine in London, has found new genetic mutations that promote the survival of cancer cells. The research also provided a clearer understanding of how some cancer cells are
Biotechnology

Childhood obesity causes lasting damage to the body

Obesity in childhood has long term health implications stretching into adulthood, a new study in the journal Obesity Reviews reveals. Examining data collected from over 300,000 participants across 18 studies, researchers from the University of Surrey identified increased arterial damage and enhanced likelihood of pre diabetes in participants who were obese in childhood. The damage, an increased thickness of these vital arteries, heightens the likelihood of an individual suffering from
Biotechnology

Georgia State Researcher Gets $4.1 Million Federal Grant to Develop Drug to Combat Ebola Virus

Dr. Christopher Basler, a professor in the Institute for Biomedical Sciences at Georgia State University, director of the university’s Center for Microbial Pathogenesis and a Georgia Research Alliance Eminent Scholar in Microbial Pathogenesis, has received a five-year, $4.1 million federal grant to develop a drug targeting Ebola virus. “We still lack any approved drugs to treat Ebola virus infection,” Basler said. “Ebola remains a significant concern. The outbreak in West
Biotechnology

Humans have three times more brown body fat

Compared to white fat, brown body fat burns through energy at an extraordinary rate. However, until now the proportion of brown fat in humans was thought to be quite small. Now a study conducted by researchers at the Technical University of Munich (TUM) has shown: The quantity of brown fat in humans is three times greater than previously known. As a consequence, new obesity and diabetes drugs that activate brown
Hepatitis Vaccines

Largest HIV Transmission Study Conducted

A new study has found that neither gay men nor heterosexual people with HIV transmit the virus to their partner, provided they are on suppressive antiretroviral treatment. The PARTNER study, which is the world's largest study of people with HIV who have had condomless sex with their HIV negative partners, was conducted by investigators from the University of Liverpool, University College London, Royal Free NHS and Rigshospitalet (one of the
Uncategorized

Penn Team Identifies Amino Acid Associated with Poor Performance Under Sleep Restriction

The amino acid acetylcarnitine may help predict an individual’s neurobehavioral performance during chronic sleep restriction, according to results of a new study (abstract 0251) from researchers at the Perelman School of Medicine at the University of Pennsylvania that will be presented at SLEEP 2016, the 30th annual meeting of the Associated Professional Sleep Societies LLC. Previous studies have shown that sleep loss degrades behavioral attention, cognitive processing and memory, but
Biotechnology Pharmaceuticals

Narcotic painkillers prolong pain in rats, says CU-Boulder study

The dark side of painkillers - their dramatic increase in use and ability to trigger abuse, addiction and thousands of fatal overdoses annually in the United States is in the news virtually every day. Brace for another shot across the bow: Opioids like morphine have now been shown to paradoxically cause an increase in chronic pain in lab rats, findings that could have far-reaching implications for humans, says a new
cancer Cancer Discovery

UCLA Researchers Identify Protein That Could Prevent Tumor Growth in Cervical Cancer

UCLA scientists have identified a protein that has the potential to prevent the growth of cervical cancer cells. The discovery could lead to the development of new treatments for the deadly disease. In a five-year study using human samples and mouse models, researchers led by Dr. Eri Srivatsan, a member of the UCLA Jonsson Comprehensive Cancer Center, found that a protein known as cystatin E/M can inhibit cellular inflammation, which
Biotechnology cancer Cancer Discovery

Precision Prevention of Colorectal Cancer

Precision medicine’s public face is that of disease — and better treatments for that disease through targeted therapies. But precision medicine has an unsung partner that could affect the lives of many more people: Precision prevention — a reflection of the growing realization that preventing cancer and other diseases may not be one-size-fits-all. “Precision medicine has been kind of a buzzword recently, but often when people think about precision medicine,
Gene Therapy Genomes

Gene Variant Explains Racial Disparities in Adverse Reactions to Urate-Lowering Drug

A multi-institutional study led by a Massachusetts General Hospital (MGH) investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life-threatening adverse reaction to the most commonly prescribed medication. The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations. "We found