Personalized Medicine

The promise of personalized medicine is not for everyone

Could your medical treatment one day be tailored to your DNA? That’s the promise of “personalized medicine,” an individualized approach that has caught the imagination of doctors and researchers over the past few years. This concept is based on the idea that small genetic differences between one person and another can be used to design tailored treatments for conditions as diverse as cancer and schizophrenia. In principle, “personalized” is not
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Pairing Cancer Genomics with Cognitive Computing Highlights Potential Therapeutic Options

A University of North Carolina Lineberger Comprehensive Cancer Center-led study has demonstrated the ability of cognitive computing to scour large volumes of data from scientific studies and databases to identify potentially relevant clinical trials or therapeutic options for cancer patients based on the genetics of their tumors. The researchers said their findings, published in the journal The Oncologist, suggest that cognitive computing applications could help physicians to stay abreast of
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FDA Announces First Approval of Targeted Therapy Based on Basket Study

Precision medicine clinical trial leads to approval of first treatment for Erdheim-Chester disease The US Food and Drug Administration (FDA) has announced that it has approved the drug vemurafenib for the treatment of patients with BRAF V600-mutant Erdheim-Chester disease (ECD). This is the first approval of a targeted therapy based on a basket study and the first-ever drug approved for ECD, a rare blood disorder. This landmark approval came as
Biotechnology cancer

Scripps Florida Scientists Create Innovative Drug Design Strategy To Improve Breast Cancer Treatment

While there have been advances in the treatment of hormone-driven breast cancer, resistance to these therapies remains a significant problem. Side effects, including an increased risk of uterine cancer among postmenopausal women, also severely curtail their use for prevention. However, a new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) offers a novel structure-based drug design strategy aimed at altering the basic landscape of this
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Antibody-Based Drug Helps “Bridge” Leukemia Patients to Curative Treatment

In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants. Inotuzumab ozogamicin, also known as CMC-544, links an antibody that targets CD22, a protein found on the surface of more than 90 percent of ALL cells. Once the drug connects to CD22, the ALL cell draws
Biotechnology cancer Cancer Discovery

Precision Prevention of Colorectal Cancer

Precision medicine’s public face is that of disease — and better treatments for that disease through targeted therapies. But precision medicine has an unsung partner that could affect the lives of many more people: Precision prevention — a reflection of the growing realization that preventing cancer and other diseases may not be one-size-fits-all. “Precision medicine has been kind of a buzzword recently, but often when people think about precision medicine,