Alzheimers and Dementia

A Common Anti-Inflammatory Therapy May Help Reduce the Risk of Developing Parkinson’s Disease

A recent study from researchers at the Icahn School of Medicine at Mount Sinai provides new insights into a link between inflammatory bowel disease (IBD) and Parkinson’s disease, and may have significant implications for the treatment and prevention of Parkinson’s disease. The recent study, published in JAMA Neurology, shows that individuals with IBD are at […]

Neurodegenerative diseases Neurology Parkinson's

A Single Concussion May Increase Risk of Parkinson’s Disease

People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Previous research has shown a strong link […]

Parkinson's Pharmaceuticals

Mutation of Worm Gene, Swip-10, Triggers Age-Dependent Death of Dopamine Neurons, Key Feature of Parkinson’s Disease

Dopamine, a signaling chemical in the brain, has the lofty job of controlling emotions, moods, movements as well as sensations of pleasure and pain. Dysfunction of this critical neurotransmitter is the cause of a number of diseases, most notably, Parkinson’s disease. Parkinson’s disease is caused by the death of dopamine-producing cells and most theories of […]

Parkinson's

Faulty Cellular Membrane “Mix” Linked To Parkinson’s Disease

Working with lab-grown human brain cells, Johns Hopkins researchers report they have uncovered a much sought-after connection between one of the most common genetic mutations in Parkinson’s disease and the formation of fatty plaques in the brain thought to contribute to the destruction of motor neurons that characterize the disease. The mutation occurs in a […]

Neuroscience Parkinson's

Parkinson’s drug to Treat OFF Episodes Hits Right Notes in Phase 3 Study

Sunovion Pharmaceuticals Inc. announced top line results from its pivotal Phase 3, randomized, double-blind, placebo-controlled clinical trials from its pivotal Phase 3, randomized, double-blind, placebo-controlled clinical trial, CTH-300, that evaluated apomorphine sublingual film (APL-130277) in patients with Parkinson’s disease (PD) who experience motor fluctuations (OFF episodes). Study CTH-300 met its primary and key secondary endpoints, […]

Biotechnology Neurology

Newly described process in Parkinson’s protein as a potential new therapy route

An international group of researchers led by Professor Wim Versées (VIB-VUB) has unraveled the workings of an essential mechanism in ‘Parkinson’s protein’ LRRK2. Their study demonstrates a direct link between the protein’s ‘dimerization’ – two copies that are bound together -and mutations that lead to Parkinson’s disease. This process could eventually lead to a promising […]

Biotechnology Clinical Trials

Pre-Clinical Study Suggests Parkinson’s Could Start in Gut Endocrine Cells

Recent research on Parkinson’s disease has focused on the gut-brain connection, examining patients’ gut bacteria, and even how severing the vagus nerve connecting the stomach and brain might protect some people from the debilitating disease. But scientists understand little about what’s happening in the gut — the ingestion of environmental toxins or germs, perhaps — […]

Biotechnology

Discovery may offer hope to Parkinson’s disease patients

The finding of a common protein abnormality in these degenerative diseases supports a hypothesis among experts that abnormal deposition of proteins in many neurodegenerative disorders reflects an early change in these proteins. “We have pinpointed a protein abnormality known as the ‘SOD1 fingerprint’ in regions of neuronal loss in the Parkinson’s disease brain,” said Associate […]

Biotechnology

UNMC Scientists Achieve Research Milestone with Parkinson’s Disease

Drug that transforms immune system may predict motor improvement In an early phase human clinical trial, researchers at the University of Nebraska Medical Center tested a drug that transforms the immune system for diagnostic and therapeutic gain in Parkinson’s disease (PD). The medicine was proven safe and generally well tolerated. Side effects were minimal, but […]

Clinical Trials Pharmaceuticals

Georgetown Announces Phase II Clinical Trial of Nilotinib for Parkinson’s Disease

Georgetown University Medical Center (GUMC) today announces the launch of a phase II clinical trial to study the safety of the cancer drug nilotinib and its effects on clinical outcomes and biomarkers in people with Parkinson’s disease. GUMC is recruiting volunteers for the study in collaboration with its clinical partner, MedStar Georgetown University Hospital. The […]

Neurodegenerative diseases Neurology

Iowa State University Scientists Identify New Lead In Search For Parkinson’s Cure

AMES, Iowa – Recently published research from Iowa State University may hint at a new treatment for Parkinson’s disease. In a paper published in the academic journal Nature Communications, ISU scientists identified a protein called Prokineticin-2 (PK2) that may protect brain cells and is expressed with greater frequency in the early stages of Parkinson’s disease. […]

Uncategorized

Parkinson’s disease biomarker found in patient urine samples

For more than five years, urine and cerebral-spinal fluid samples from patients with Parkinson’s disease have been locked in freezers in the NINDS National Repository, stored with the expectation they might someday help unravel the still-hidden course of this slow-acting neurodegenerative disease. Now, research by Andrew West, Ph.D., and colleagues at the University of Alabama […]

Biotechnology Cell Therapy Clinical Trials Genomes

Cell Transplant Treats Parkinson’s in Mice Under Control of Designer Drug

A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson’s disease. Dopamine […]