cancer Cancer Discovery

Compound Derived From Chinese Tree Bark Shows Promise as Treatment for Pancreatic Cancer

 A new derivative of a compound found in the bark of a rare Chinese tree has powerful anticancer properties and a low toxicity profile, according to researchers at Roswell Park Comprehensive Cancer Center. Results of their study of the effects of the compound F118 in pancreatic cancer were published in the Journal of Experimental & Clinical Cancer Research. Pancreatic cancer is one of the most difficult cancers to treat. Even with
cancer Cancer Discovery

New Drug Blocks Pancreatic Cancer Growth in Mice, Study Finds

A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study, published recently in the journal Gastroenterology, also demonstrated in mice that the drug, called Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer chemotherapies. “This is an exciting step toward improving survival rates in pancreatic cancer patients,” said
Cancer Discovery

Despite Risk of Breast Cancer, Few Men Undergo Genetic Tests, Study Finds

Cancer is one of the leading causes of death among Americans. At least 10 percent of cancers are caused by inherited mutations in genes such as BRCA1 and BRCA2. Parents with the cancer gene mutation have a 50 percent chance of passing it on to a son or daughter. It’s well-known that women with BRCA are at a very high risk for breast and ovarian cancer. Less known is the
Cancer Discovery

Improving Survival in Pancreatic Cancer with Platinum-Based Chemotherapy

A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations. The same study also found that those with BRCA1 or BRCA2 had better survival rates with platinum-based chemotherapy, compared with similar patients who received other drugs or
cancer Cancer Discovery

Improving Survival in Pancreatic Cancer with Platinum-Based Chemotherapy

A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations. The same study also found that those with BRCA1 or BRCA2 had better survival rates with platinum-based chemotherapy, compared with similar patients who received other drugs or
Alzheimers and Dementia

Researchers Identify Epigenetic Orchestrator of Pancreatic Cancer Cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect against this deadly form of cancer. The vast majority of cancers originate in
Biotechnology cancer

‘Collateral’ Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as “collateral lethality,” which may create new options for development of therapies for several cancers. Scientists at The University of Texas MD Anderson Cancer Center have discovered that during early cancer development when a common tumor suppressor known as SMAD4 is deleted, a nearby metabolic enzyme gene called malic
cancer Gene Therapy

Potentially Reversible Changes in Gene Control ‘Prime’ Pancreatic Cancer Cells to Spread

Epigenetic changes, not DNA mutations, drive some metastasis multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. Those advantages, the researchers say, let such cancer cells thrive
Biotechnology

Study Shows Low-Dose Chemotherapy Regimens Could Prevent Tumor Recurrence In Types Of Breast Cancer And Pancreatic Cancer

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors’ recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered. Frequent, low-dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the
cancer

Johns Hopkins Scientists Track Metabolic Pathways To Find Drug Combination For Pancreatic Cancer

Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments. Now, in a new study using laboratory-grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target
cancer Cancer Discovery

Cell Death – Paradoxically – Promotes Tumor Growth in Most Aggressive Form of Pancreatic Cancer

The most aggressive form of pancreatic cancer – often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of “orchestrated cell death.” This is according to a major study recently published in the journal Nature. The study results revolve around carefully regulated cell dell death mechanisms that, by killing defective cells or those infected by