Alzheimers and Dementia

Researchers Identify Epigenetic Orchestrator of Pancreatic Cancer Cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only […]

Biotechnology cancer

‘Collateral’ Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as “collateral lethality,” which may create new options for development of therapies for several cancers. Scientists at The University of Texas MD Anderson Cancer Center have discovered that during early cancer development when a […]

cancer Gene Therapy

Potentially Reversible Changes in Gene Control ‘Prime’ Pancreatic Cancer Cells to Spread

Epigenetic changes, not DNA mutations, drive some metastasis multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on […]

Biotechnology

Study Shows Low-Dose Chemotherapy Regimens Could Prevent Tumor Recurrence In Types Of Breast Cancer And Pancreatic Cancer

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors’ recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered. Frequent, low-dose chemotherapy regimens avoid this effect and may therefore […]

cancer

Johns Hopkins Scientists Track Metabolic Pathways To Find Drug Combination For Pancreatic Cancer

Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments. Now, in a new study using laboratory-grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining […]

cancer Cancer Discovery

Cell Death – Paradoxically – Promotes Tumor Growth in Most Aggressive Form of Pancreatic Cancer

The most aggressive form of pancreatic cancer – often described as one of the hardest malignancies to diagnose and treat — thrives in the presence of neighboring tumor cells undergoing a particular form of “orchestrated cell death.” This is according to a major study recently published in the journal Nature. The study results revolve around […]