Biotechnology Diabetes

Key to Weight Loss in 2019: Don’t Diet: Lose Weight!

The South Bronx is notorious for its high obesity and diabetes rates ---the highest in New York State. But Loretta Fleming, as part of a group of community health educators, is fighting this trend with new success. Loretta, herself, was a diabetic who weighed 378 pounds when she took an intensive course in diabetes self-management offered by the South Bronx community group Health People. In three years, she lost 108
Diabetes

Amount of Weight Regain After Bariatric Surgery Helps Predict Health Risks

Measuring the percentage of weight regained following the maximum amount of weight lost after bariatric surgery can help predict a patient’s risk of several serious health problems, according to a long-term, multicenter study led by University of Pittsburgh Graduate School of Public Health researchers. The results, published today in JAMA, also found that, while on average study participants achieved maximum weight loss at two years post-surgery, when they reached that milestone varied substantially,
Cardiology

Weight loss drug shows no increased risk in cardiovascular outcomes

For the first time, investigators report that a weight loss drug led to weight loss without increasing the incidence of heart attacks, strokes and death from heart disease in a population of people who are especially at risk for cardiovascular events. At the 2018 European Society of Cardiology meeting, Brigham and Women's Hospital investigators from the Thrombolysis in Myocardial Infarction (TIMI) Study Group presented findings from CAMELLIA-TIMI 61, a clinical
Biotechnology

Natural sugar defends against metabolic syndrome, in mice

Trehalose blocks glucose from liver New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in the blood. The findings, from researchers at Washington University School of
Biotechnology Cell Therapy Diabetes Pharmaceuticals

Diabetes Drugs Act as Powerful Curb for Immune Cells in Controlling Disease-causing Inflammation

Controlling Immune System Fuel Puts the Brakes on Macrophage Damage When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a common class of drugs used to treat diabetes has been found to exert a powerful
Biotechnology

New Study Could Change the Way We Think about Obesity and Health

[embed]https://www.youtube.com/watch?v=pqTbUUT8JnM&feature=youtu.be[/embed] Researchers at York University's Faculty of Health have found that patients who have metabolic healthy obesity, but no other metabolic risk factors, do not have an increased rate of mortality. The results of this study could impact how we think about obesity and health, says Jennifer Kuk, associate professor at the School of Kinesiology and Health Science, who led the research team at York University. "This is in contrast
cancer Cancer Discovery

Obesity is Shifting Cancer to Young Adults

A Case Western Reserve University School of Medicine researcher has compiled evidence from more than 100 publications to show how obesity increases risk of 13 different cancers in young adults. The meta-analysis describes how obesity has shifted certain cancers to younger age groups, and intensified cellular mechanisms promoting the diseases. Cancer typically associated with older adults over 50 are now reported with increasing frequency in young adults. Of the 20
Biotechnology cancer Cell Therapy Clinical Trials Heart Health

Bariatric surgery lowers cancer risk for severely obese patients

Severely obese patients who undergo bariatric surgery lower their risk of developing cancer by at least a third, according to a University of Cincinnati (UC) College of Medicine researcher leading a large retrospective cohort study of patients in the western United States. "We found having bariatric surgery is associated with a reduced risk of cancer, especially obesity-associated cancers including postmenopausal breast cancer, endometrial cancer, pancreatic cancer and colon cancer," explains
Biotechnology Prodrug

Scientists Discover Common Obesity and Diabetes Drug Reduces Rise in Brain Pressure

Research led by the University of Birmingham, published today in Science Translational Medicine, has discovered that a drug commonly used to treat patients with either obesity or Type II diabetes could be used as a novel new way to lower brain pressure. Raised brain pressure is common in emergency situations such as traumatic brain injury, hydrocephalus and stroke, and is also the cardinal feature of Idiopathic Intracranial Hypertension (IIH). IHH
Biotechnology Clinical Trials Pharmaceuticals

New combination of anti-obesity drugs may have beneficial effects

Research conducted in the Perelman School of Medicine at the University of Pennsylvania has revealed that a unique combination of hormone-based drugs can produce enhanced weight loss in laboratory tests with obese animals. The research is to be presented this week at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior. "Imagine a
Biotechnology

Obesity risk factors dropped in preschoolers in prevention program

Preschoolers from low-income families living in cities that took part in a two-year community-wide intervention to foster healthy eating and lifestyle habits consumed fewer sugary drinks, got more sleep, and showed improvement in weight, according to a study led by a researcher at NewYork-Presbyterian/Columbia University Medical Center (CUMC). The study--one of a trio of studies published today in Obesity--was designed to test a childhood obesity-prevention program known as the Massachusetts
Biotechnology Diabetes

Study reveals sweetened drinks during pregnancy puts infants at higher risk for obesity

A recent Danish study of children born to women with gestational diabetes, found that maternal daily consumption of artificially-sweetened beverages during pregnancy was associated with a higher body mass index score and increased risk of overweight/obesity at 7 years. Artificial sweeteners are widely replacing caloric sweeteners, due to the health concern related to sugar-sweetened beverages (SSBs) within the general population. Artificially sweetened beverages have been considered as potential healthier alternatives,
Biotechnology

Childhood obesity causes lasting damage to the body

Obesity in childhood has long term health implications stretching into adulthood, a new study in the journal Obesity Reviews reveals. Examining data collected from over 300,000 participants across 18 studies, researchers from the University of Surrey identified increased arterial damage and enhanced likelihood of pre diabetes in participants who were obese in childhood. The damage, an increased thickness of these vital arteries, heightens the likelihood of an individual suffering from
Biotechnology

Urine Metabolites May Help Predict Which Obese Teens Will Develop Diabetes

Researchers have discovered a unique metabolic “signature” in the urine of diabetic, obese black teenagers that they say may become a way to predict the development of type 2 diabetes in people at risk. They will present their results Tuesday at the Endocrine Society’s 99th annual meeting in Orlando, Fla. In detailed metabolic analyses, the level of the main metabolite, or byproduct, of serotonin was “strikingly lower” in obese youth
Biotechnology

Humans have three times more brown body fat

Compared to white fat, brown body fat burns through energy at an extraordinary rate. However, until now the proportion of brown fat in humans was thought to be quite small. Now a study conducted by researchers at the Technical University of Munich (TUM) has shown: The quantity of brown fat in humans is three times greater than previously known. As a consequence, new obesity and diabetes drugs that activate brown
Biotechnology

Children with Asthma May Be at Higher Obesity Risk

Children with asthma may be more likely to become obese later in childhood or in adolescence, according to new research published online ahead of print in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. In “Effects of Childhood Asthma on the Development of Obesity among School-Aged Children,” researchers report that young children with asthma were 51 percent more likely to become obese over the next decade
Biotechnology cancer

The Role of Common Risk Factors in ER-Positive, ER-Negative Breast Cancer

Karla Kerlikowske, MD, and team recently published a paper in the Journal of the National Cancer Institute that examined the role of common risk factors in the development of ER-positive and ER-negative breast cancers. The study sheds new light on how a woman’s age, weight, and menopausal status affect her risk for breast cancer. Dr. Kerlikowske discusses the findings below. What was the aim of the study? The goal of
Biotechnology

There Are at Least 59 Types of Obesity, According to Researchers

It’s a strange fact that if two obese people have the same amount of excess weight, one diet might work really well for one and do nothing for the other. Even weight-loss experts are stumped as to why this happens. But increasingly, they think that it’s because obesity isn’t one disease — rather, it has many different subtypes all with their own methods of prevention and treatment. (The New York
Biotechnology Cell Therapy

Rare Obesity Syndrome Therapeutic Target Identified

Columbia University Medical Center (CUMC) researchers have discovered that a deficiency of the enzyme prohormone covertase (PC1) in the brain is linked to most of the neuro-hormonal abnormalities in Prader-Willi syndrome, a genetic condition that causes extreme hunger and severe obesity beginning in childhood. The discovery provides insight into the molecular mechanisms underlying the syndrome and highlights a novel target for drug therapy. The findings were published online today in
Diabetes Hepatitis

Fatty Liver: Turning Off TAZ Reverses Disease

Scientists at Columbia University Medical Center (CUMC) have identified a factor in liver cells that is responsible for turning a relatively benign liver condition, present in 30 percent of U.S. adults, into a serious disease that can lead to liver failure. The study was published online today in Cell Metabolism. With the rise of obesity in the U.S., the incidence of nonalcoholic fatty liver disease (NAFLD)—in which excess fat fills