Biotechnology Immunotherapies

Nuclear Pore Functions Are Essential for T Cell Survival

Study reveals an unexpected regulatory role for Nup210 in T cell homeostasis Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus—they play an essential role in the survival of T cells. A new study by Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers describes how a specific nuclear pore component is critical for the survival of circulating T cells.