Alzheimers and Dementia

Study Predicts Most People with Earliest Alzheimer’s Signs Won’t Develop Dementia Associated with the Disease

 During the past decade, researchers have identified new ways to detect the earliest biological signs of Alzheimer’s disease. These early signs, which are detected by biomarkers, may be present before a person starts to exhibit physical symptoms. What biomarker screening doesn’t reveal, however, is how likely it is that a person who tests positive will […]

Alzheimers and Dementia

Researchers Identify Gene That Helps Prevent Brain Disease

Scientists know that faulty proteins can cause harmful deposits or “aggregates” in neurological disorders such as Alzheimer’s and Parkinson’s disease. Although the causes of these protein deposits remain a mystery, it is known that abnormal aggregates can result when cells fail to transmit proper genetic information to proteins. University of California San Diego Professor Susan […]

Neurology

Defect in Debilitating Neurodegenerative Disease Reversed in Mouse Nerves

Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs. The researchers used the compound to treat the nerves of mice harboring the genetic defects that cause the disease. The new study, […]

Neurodegenerative diseases Neurology

Preliminary Study Suggests Drug May Help Babies with Spinal Muscular Atrophy

A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. Spinal muscular atrophy (SMA) is an inherited disease that […]

Alzheimers and Dementia

Study: Brain Injury May Boost Risk of Alzheimer’s Earlier in Life

Concussions and other traumatic brain injuries may increase the risk of developing Alzheimer’s disease earlier in life, according to a study from UT Southwestern’s Peter O’Donnell Jr. Brain Institute. The research – the first to use autopsy-confirmed cases of Alzheimer’s disease to examine the long-term effects of head injuries – supports a correlation that could only be […]

Autism

Cognitive Enhancement Therapy Improves Outcomes for Adults with Autism

New collaborative research out of the University of Pittsburgh School of Social Work and the Department of Psychiatry signals a potential breakthrough for adults with autism spectrum disorder (ASD). While there have been advances in early detection and many studies involving the treatment of children with ASD, few efforts to date have focused on interventions […]

cancer

Enzyme Inhibitor Combined with Chemotherapy Delays Glioblastoma Growth

 In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide. The regression seen in this combination therapy of temozolomide and the inhibitor SLC-0111 — which targets the enzyme carbonic anhydrase 9, or CA9 — was greater than that seen with […]

Neurology Neuroscience

Potential New Autism Drug Shows Promise in Mice

Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the mice. NitroSynapsin is intended to restore an electrical signaling imbalance in the brain found in virtually all forms of autism spectrum disorder […]

cancer

Proton Therapy Lowers Treatment Side Effects in Pediatric Head and Neck Cancer Patients

Pediatric patients with head and neck cancer can be treated with proton beam therapy (PBT) instead of traditional photon radiation, and it will result in similar outcomes with less impact on quality of life. Researchers from the Perelman School of Medicine at the University of Pennsylvania as well as Children’s Hospital of Philadelphia analyzed cases of pediatric head and […]

Biotechnology

A Dietary Supplement Dampens the Brain Hyperexcitability Seen in Seizures or Epilepsy

Seizure disorders — including epilepsy — are associated with pathological hyperexcitability in brain neurons. Unfortunately, there are limited available treatments that can prevent this hyperexcitability. However, University of Alabama at Birmingham researchers have found that inducing a biochemical alteration in brain proteins via the dietary supplement glucosamine was able to rapidly dampen that pathological hyperexcitability in rat […]

Cancer Discovery Immunotherapies

Cell Surface Protein May Offer Big Target in Treating High-Risk Childhood Cancers

Oncology researchers studying high-risk children’s cancers have identified a protein that offers a likely target for immunotherapy–harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells. “We have built a strong foundation for developing a […]

Alzheimers and Dementia Biotechnology

Researchers Find a Potential Target for Anti-Alzheimer’s Treatments

Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have identified a gene that may provide a new starting point for developing treatments for Alzheimer’s disease (AD). The USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset […]

cancer Cancer Discovery Neurology

Brain Cancer And Leukemia: New Molecular Mechanisms Decoded

Brain cancer and leukemia are two potentially fatal diseases that affect thousands of Canadians each year. But a joint study conducted by researchers Frederick Antoine Mallette, of the Maisonneuve-Rosemont Hospital Research Centre and the University of Montreal, and Marc-Étienne Huot, of Laval University, and published in the prestigious scientific journal Nature Communications has uncovered new […]

cancer

Stereotactic Radiosurgery May Be Best for Patients with Metastatic Brain Tumors

Patients with three or fewer metastatic brain tumors who received treatment with stereotactic radiosurgery (SRS) had less cognitive deterioration three months after treatment than patients who received SRS combined with whole brain radiation therapy (WBRT). These findings are according to the results of a federally funded, Mayo Clinic-led, multi-institution research study published today in the […]

cancer Cancer Discovery

International Study Finds Effective, Less Toxic Way to Treat Brain Tumors

Physicians from Carolinas HealthCare System’s Neurosciences Institute and Levine Cancer Institute are among the authors of a study that was accepted for publication by the Journal of the American Medical Association (JAMA). The study, released on July 26, 2016, shows that patients with the most common form of brain tumor can be treated in an […]

Alzheimers and Dementia Antibiotics

Antibiotics Weaken Alzheimer’s Disease Progression Through Changes in the Gut Microbiome

Long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer’s disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists from the University of Chicago. The study, published July 21, 2016, in Scientific Reports, also showed significant changes in the gut microbiome after […]

Uncategorized

Changes Uncovered in the Gut Bacteria of Patients with Multiple Sclerosis

A connection between the bacteria living in the gut and immunological disorders such as multiple sclerosis have long been suspected, but for the first time, researchers have detected clear evidence of changes that tie the two together. Investigators from Brigham and Women’s Hospital (BWH) have found that people with multiple sclerosis have different patterns of […]

Alzheimers and Dementia

Understanding How Chemical Changes in the Brain Affect Alzheimer’s Disease

A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine – a target for anticholinergic drugs – […]