Biotechnology cancer Cancer Discovery Cell Therapy drug development

Anti-Malaria Drugs Have Shown Promise in Treating Cancer, and Now Researchers Know Why

Anti-malaria drugs known as chloroquines have been repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor. Now, researchers from the Abramson Cancer Center of the University of Pennsylvania say they have identified that target – an enzyme called PPT1 – opening up a new pathway for potential cancer treatments. The team also used CRISPR/Cas9 gene editing
Biotechnology rare diseases

How Malaria Parasites Take Over Human Red Blood Cells, According to Newly Published Research

Researchers at Iowa State University have gained new insight into how the parasitic protozoa that cause malaria hijack human red blood cells, a development with the potential to lead to new ways to treat the disease. The parasites that cause malaria symptoms in humans enter the red blood cells of a host and quickly rearrange things to their liking by inserting their own proteins into the red blood cell. But
Biotechnology Gene Therapy Infectious Diseases Vaccines

Discovery of key molecules involved in severe malaria

Malaria*1 is one of three major infectious diseases*2 affecting approximately 300 million people every year, accounting for about 500,000 deaths, but effective vaccine development has not been successful. Among malaria parasites infecting humans, Plasmodium falciparum (P. falciparum)*3 causes especially severe disease. In addition, acquired immunity to malaria is inefficient, even after repeated exposures to P. falciparum, but the immune regulatory mechanisms used by P. falciparum remain largely unclear. Therefore, malaria
Clinical Trials Pharmaceuticals

‘Open Science’ Paves New Pathway To Develop Malaria Drugs

Malaria remains one of the world’s leading causes of mortality in developing countries. Last year alone, it killed more than 400,000 people, mostly young children. This week in ACS Central Science, an international consortium of researchers unveils the mechanics and findings of a unique “open science” project for malaria drug discovery that has been five years in the making. The current gold standard antimalarial treatments are based on artemisinin, a
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How Do You Kill a Malaria Parasite? Clog It with Cholesterol

Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely. Malaria is a mosquito-borne disease caused by Plasmodium parasites. After a person is bitten, the parasite invades the victim’s red blood cells. There,