A large multi-ethnic study of healthy individuals found that high circulating levels of an inflammatory marker are linked with long-term decline of kidney function. The results, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), may lead to new insights on the mechanisms behind the development of kidney disease. Tumor necrosis factor receptor-1 (TNFR-1), which is known to contribute to inflammation and dysfunction
A deceased donor kidney has been preserved and kept healthy outside the body in a device that mimics the body’s physiological functions and successfully transplanted into a human, for the first time in North America. The technique, unique solution, and device are part of a Phase I clinical trial at Toronto General Hospital (TG), University Health Network (UHN), assessing the safety of the device, with subsequent phases examining its efficacy.
A team from the University of Montreal Hospital Research Centre (CRCHUM) has discovered a novel link between chronic kidney disease and diabetes. When kidneys fail, urea that builds up in the blood can cause diabetes, concludes a study published today in the Journal of Clinical Investigation. "We identified molecular mechanisms that may be responsible for increased blood glucose levels in patients with non-diabetic chronic kidney disease. Our observations in mice
Early findings by researchers at the University of Cincinnati (UC) College of Medicine suggest that the use of a second generation cancer drug, carfilzomib, may provide an improved approach for the reduction of antibodies in potential kidney transplant candidates. The research team includes members from UC Transplant Clinical Research, UC’s Division of Hematology Oncology and the Cincinnati Children’s Hospital Medical Center’s Biomedical Informatics division. This pre-transplant drug therapy approach is