Biotechnology

Next step towards replacement therapy in type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. This breakthrough published in the journal Nature will facilitate the manufacturing of pancreatic islet cells from stem cells and might help combating type 1 diabetes. Prof. Dr. Henrik Semb who led the study recently joined Helmholtz
Alzheimers and Dementia

Diabetes Medications May Reduce Alzheimer’s Disease Severity, Mount Sinai Researchers Report

People with Alzheimer’s disease who were treated with diabetes drugs showed considerably fewer markers of the disease including abnormal microvasculature and disregulated gene expressions in their brains compared to Alzheimer’s patients  without treatment for diabetes, Mount Sinai researchers report. Results of the study will be published in PLOS One online on November 1st at 2PM. This is the first study to examine what happens in the pathways of both brain tissue and endothelial
Biotechnology

Compounds in cocoa may help delay onset of type 2 diabetes

What if eating chocolate helped prevent and treat diabetes? It's crazy enough to laugh off. But here's the thing: BYU researchers have discovered certain compounds found in cocoa can actually help your body release more insulin and respond to increased blood glucose better. Insulin is the hormone that manages glucose, the blood sugar that reaches unhealthy levels in diabetes. Of course, there's a catch. "You probably have to eat a
Biotechnology Uncategorized

The Lancet Diabetes & Endocrinology: Gastric Bypass Helps Severely Obese Teenagers Maintain Weight Loss Over Long Term

Two studies show surgery leads to significant weight loss and health benefits over 5-12 years, but may lead to more surgery and vitamin deficiency in some. Gastric bypass surgery helps severely obese teenagers lose weight and keep it off, according to the first long-term follow-up studies of teenagers who had undergone the procedure 5-12 years earlier. However, the two studies, published in The Lancet Diabetes & Endocrinology, show some patients
Biotechnology Diabetes Gene Therapy

Researching Proinsulin Misfolding to Understand Diabetes

  According to the World Health Organization, 422 million adults across the globe have diabetes. In fact, the number of adults with the disease continues to grow each year. To help the growing patient population, researchers at the University of Michigan are going down to the molecular level. Here, they’re trying to determine what makes cells in the diabetic pancreas less efficient in generating insulin molecules. Diabetes occurs when the
Diabetes

Stealth Pig Cells May Hold The Key To Treating Diabetes In Humans

University of Alabama at Birmingham researchers are exploring ways to wrap pig tissue with a protective coating to ultimately fight diabetes in humans. The nano-thin bilayers of protective material are meant to deter or prevent immune rejection. The ultimate goal: transplant insulin-producing cell-clusters from pigs into humans to treat Type 1 diabetes. In preclinical work begun this year, these stealth insulin-producers — pancreatic islets from pigs or mice coated with
Diabetes

Researchers: Insulin Pill Could Make Diabetes Treatment ‘Ouchless’

Every day, millions of Americans with diabetes have to inject themselves with insulin to manage their blood-sugar levels. But less painful alternatives are emerging. Scientists are developing a new way of administering the medicine orally with tiny vesicles that can deliver insulin where it needs to go without a shot. Today, they share their in vivo testing results. The researchers are presenting their work at the 252nd National Meeting &
Diabetes

Joint Research Collaboration Aims to Advance Human Clinical Trials for the Treatment of Hypoglycemic Unawareness Patients with Severe Type 1 Diabetes

A new research funding agreement between the Juvenile Diabetes Research Foundation (JDRF) and Sernova, a clinical-stage regenerative medicine biotech, aims to address people with severe type 1 diabetes (T1D) who are hypoglycemia unaware, a condition in which a person with diabetes does not experience the usual early warning symptoms of hypoglycemia (low blood sugar) following an insulin injection. The purpose of the funding is to advance human clinical trials of