Antibiotics

Triclosan, often maligned, may have a good side — treating cystic fibrosis infections

Antibiotic-resistant bacteria inside a biofilm. Kateryna Kon/Shutterstock.com Chris Waters, Michigan State University Maybe you’ve had the experience of wading in a stream and struggling to keep your balance on the slick rocks, or forgetting to brush your teeth in the morning and feeling a slimy coating in your mouth. These are examples of bacterial biofilms […]

Biotechnology Cell Therapy Diabetes Pharmaceuticals

Diabetes Drugs Act as Powerful Curb for Immune Cells in Controlling Disease-causing Inflammation

Controlling Immune System Fuel Puts the Brakes on Macrophage Damage When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a […]

Biotechnology Cell Therapy Immunotherapies Uncategorized

Potential new approach to the treatment of multiple sclerosis

A prospective new method of treating patients with multiple sclerosis has been proposed by researchers of the Mainz University Medical Center working in cooperation with researchers of the University of Montreal. In model trials and experiments employing human endothelial cells, they discovered that the EGFL7 protein hinders the migration of immune cells into the central […]

Immunotherapies Infectious Diseases

Confronted with bacteria, infected cells die so others can live, Penn study finds

The immune system is constantly performing surveillance to detect foreign organisms that might do harm. But pathogens, for their part, have evolved a number of strategies to evade this detection, such as secreting proteins that hinder a host’s ability to mount an immune response. In a new study, a team of researchers led by Igor […]

Biotechnology

Immune Cells Produce Wound Healing Factor, Could Lead To New IBD Treatment

Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study. The research team, led by Georgia State University and the University of Michigan, wanted to […]

cancer Immunotherapies

New Study Highlights Role for Immune Cells in Cancer’s Ability to Evade Immunotherapy

One of the main reasons cancer remains difficult to treat is that cancer cells have developed a multitude of mechanisms that allow them to evade destruction by the immune system. One of these escape mechanisms involves a type of immune cell called myeloid-derived suppressor cells (MDSCs). A recent study led by Sharon Evans, PhD, Professor […]

Cell Therapy Genomes Immunotherapies

LJI Scientists Flip Molecular Switches To Distinguish Closely Related Immune Cell Populations

The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or otherwise destroy gene X in that tissue and then watch what happens. That genetic […]

cancer Cancer Discovery Cell Therapy

St. Jude Researchers Reveal How Two Types of Immune Cells Can Arise From One

The fates of immune cells can be decided at the initial division of a cell. Researchers at St. Jude Children’s Research Hospital have discovered that the production of daughter cells with different roles in the immune system is driven by the lopsided distribution of the signaling protein c-Myc. Nudging c-Myc in one direction or the […]