Infectious Diseases

‘Molecular Scissors’ Could Be Key to Cutting Off Diseases Including HIV Infection

One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works to influence the immune system, new research suggests. The study, led by researchers from The Ohio State University, details how the enzyme influences proteins that stimulate the immune response. SAMHD1 isn’t a molecular […]

Cardiology

Individuals with HIV at Higher Risk for Heart Disease

A review of more than 80 studies reveals that changes in the immune cells of people with human immunodeficiency virus (HIV) infection may increase their risk of cardiovascular disease (CVD). The review is published in the journal Physiology. Combination antiretroviral therapy (cART) consists of a “cocktail” of several drugs that work together to reduce the amount of detectable […]

Biotechnology Uncategorized

First Long-Term Study on Medical Marijuana’s Impact on Opioid Use for Pain

The National Institutes of Health (NIH) has awarded researchers at Albert Einstein College of Medicine and Montefiore Health System a five-year, $3.8 million grant for the first long-term study to test whether medical marijuana reduces opioid use among adults with chronic pain, including those with HIV. Millions of Americans experience chronic, severe pain as a […]

Immunotherapies Vaccines

Experimental HIV vaccine regimen is well-tolerated, elicits immune responses

Results from an early-stage clinical trial called APPROACH show that an investigational HIV vaccine regimen was well-tolerated and generated immune responses against HIV in healthy adults. The APPROACH findings, as well as results expected in late 2017 from another early-stage clinical trial called TRAVERSE, will form the basis of the decision whether to move forward […]

Pharmaceuticals

Computer Models Could Allow Researchers to Better Understand, Predict Adverse Drug Reactions

New computer models from North Carolina State University show how a variant of a common protein involved in human immune response binds to the antiviral drug abacavir, causing a severe life-threatening reaction known as the abacavir hypersensitivity syndrome (AHS). The work has implications for predicting severe adverse reactions caused by existing drugs and future drug […]

cancer Cancer Discovery Cell Therapy Vaccines

UMN researchers find distinct differences in structure, features of retroviruses

In the most comprehensive study of its kind, researchers in the Institute for Molecular Virology and School of Dentistry at the University of Minnesota report that most types of retroviruses have distinct, non-identical virus structures. Researchers analyzed seven different retroviruses including two types of HIV as well as HTLV-1, a virus that causes T-cell leukemia. […]

Antibiotics Biotechnology

New Research Explains Why HIV Is Not Cleared by the Immune System

Scientists at the University of North Carolina (UNC) School of Medicine and Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings, published today in Cell Host & Microbe, have important implications for improving HIV antiviral therapies, creating effective viral […]

Biotechnology

New Method Developed to Preserve Microfluidic Devices for HIV Monitoring in Developing Countries

Providing vital health care services to people in developing countries without reliable electricity, refrigeration and state-of-the-art medical equipment poses a number of challenges. Inspired by pregnancy tests, researchers from Florida Atlantic University, Stanford University, and Baskent University in Turkey, have developed a novel method to store microfluidic devices for CD4 T cell testing in extreme […]