heparan sulfate Archives – The Bio Connection

Abeona Therapeutics Reports Top-Line Data from Phase 1/2 Gene Therapy Trial in Sanfillippo Syndrome

February 8, 2018February 9, 2018 TheBioConnection Comment(0)

Abeona Therapeutics Inc., a leading clinical-stage biopharmaceutical company focused on developing novel cell and gene therapies for life-threatening rare genetic diseases, announced updated clinical data from the ongoing Phase 1/2 trial for ABO-102 (AAV-SGSH), the company’s investigational gene therapy for the treatment of Sanfilippo syndrome Type A (MPS IIIA), a rare autosomal-recessive lysosomal storage disease. […]

New drug could prevent debilitating side effect of cancer treatment August 20, 2018
About 50,000 people in the US are diagnosed annually with head, neck, nasal and oral cancers. Most are treated with radiation, and of those, 70-80 percent develop a painful and debilitating side effect called severe oral mucositis. A new drug could potentially prevent the condition.
E-cigarettes can damage DNA August 20, 2018
The popularity of electronic cigarettes continues to grow worldwide, as many people view them as a safer alternative to smoking. But the long-term effects of e-cigarette usage, commonly called 'vaping,' are unknown. Today, researchers report that vaping may modify the genetic material, or DNA, in the oral cells of users, which could increase their cancer […]
A GPS for inside your body August 20, 2018
Scientists have developed a system that can pinpoint the location of ingestible implants inside the body using low-power wireless signals.
Weaponizing oxygen to kill infections and disease August 19, 2018
The life-threatening bacteria MRSA can cripple a medical facility since it is resistant to treatment. But scientists report that they are now making advances in a new technique that avoids antibiotics, instead using light to activate oxygen, which wipes out bacteria. The method also could be used to treat other microbial infections, and possibly even […]
Insight into development of lung cancer August 18, 2018
Lung cancer results from effects of smoking along with multiple genetic components. A new study identifies two main pathways for the role of chromosome 15q25.1 -- a leader in increasing susceptibility to lung cancer -- in modifying disease risk. One pathway is implicated in nicotine dependence. The other plays a part in biological processes such […]
Like shark attacks and the lottery, unconscious bias influences cancer screening August 17, 2018
Study shows that doctors with personal experience of cancer are more likely to act against established guidelines to recommend that low-risk women receive ovarian cancer screening.
Exploring the relationship between fever and cancer incidence August 17, 2018
In a new paper, researchers propose a mechanistic hypothesis that focuses on the potential impact infectious fever has on a particular subset of T cells, known as gamma/delta T cells.
New CRISPR technique skips over portions of genes that can cause disease August 16, 2018
In a new study in cells, researchers have adapted CRISPR gene-editing technology to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such […]
New approach to fight tuberculosis, a leading cause of death worldwide August 16, 2018
A group of researchers used a systematic approach to get an entirely new look at the way tuberculosis infects people. Their study uncovered interactions between tuberculosis and human proteins that could provide new approaches to combat infection.
Diagnosing cancer with malaria protein: New method discovered August 16, 2018
Researchers have discovered a method of diagnosing a broad range of cancers at their early stages by utilizing a particular malaria protein, which sticks to cancer cells in blood samples. The researchers hope that this method can be used in cancer screenings in the near future.

IPO Roundup: Bionano Genomics, Megalith Financial Acquisition and Tenzing Acquisition to tap the capital markets August 20, 2018
Bionano Genomics plans to raise around US$16mln to boost its presence as a life sciences instrumentation company in the genome analysis space
Lannett Co shares crash after losing customer contract as profit warning issued August 20, 2018
A major distribution agreement with Jerome Stevens Pharmaceuticals was not renewed
Q BioMed takes the final step toward FDA approval of its bone pain relief injectable August 20, 2018
The non-narcotic injectable drug is designed to relieve pain in patients with skeletal cancer
Arix Bioscience share sale explains recent market disconnect, say brokers August 20, 2018
Chris Chipperton, a founder of the company, sold 3mln shares or around a third of his stake at 155p
NMC Health shares jump as it issues positive outlook after strong first half August 20, 2018
NMC Health boss Prasanth Manghat said he sees “continuing good growth potential across different parts of the group in 2019 and beyond"
Silence Therapeutics chair Annalisa Jenkins steps down August 20, 2018
Silence Therapeutics said non-executive director Andy Richards has been appointed interim chair
Cannabis stocks in Canada recover after a whirlwind week; Canopy Growth up 8.6% on Friday August 17, 2018
Cannabis stocks stabilized in Canada on Friday after doing significant drops and bumps this week on the back of a host of news in the country that is nearing recreational legalized marijuana in Oct.
Small-Cap Snapshot: Investors smile as Evolus wins approval to market its Botox-like treatment in Canada August 17, 2018
Small cap names on the move are: Evolus Inc (NASDAQ:EOLS), Zoë's Kitchen Inc (NYSE:ZOES), America’s Car-Mart Inc (NASDAQ:CRMT), Zion Oil & Gas Inc (NASDAQ:ZN).
Callitas Health ropes in BFS Innovations and Pure Leaf Group to launch CannaStrips globally August 17, 2018
The Cincinnati-based company has developed a novel delivery technology that helps achieve more precise dosing — a tricky undertaking when it comes to medical cannabis
Antares stock surges on FDA approval of VIBEX auto injector August 17, 2018
Auto injector drug device combination approved by the FDA

STAT Plus: Up and down the ladder: The latest comings and goings August 17, 2018
Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot?
STAT Plus: Pharmalittle: Trump wants opioid makers to cut production quotas; Purdue looks to restructure August 17, 2018
Purdue Pharma has hired the Davis Polk & Wardwell law firm for financial restructuring advice.
STAT Plus: Senators challenge Azar over his comments about PBMs and price cuts August 17, 2018
“Congress cannot appropriately fix the problem of high drug prices unless we have correct information about what is causing them and who is responsible.”
STAT Plus: China takes action against numerous officials for allowing vaccine scandal to erupt August 16, 2018
The scandal emerges while the Chinese government is trying to grow its domestic pharmaceutical industry.
STAT Plus: An 8-year-old boy puts Vertex on the defensive over the price of its drugs in the U.K. August 16, 2018
Vertex Pharmaceuticals (VRTX) is facing pushback from cystic fibrosis patients and their families as it plays hardball with the U.K. government over the cost of its medicines. In a highly…
STAT Plus: Pfizer resumes full production at a troubled plant, but don’t expect shortages to suddenly end August 16, 2018
"Things are going to unfortunately be ugly on the drug-shortage front for a long time," said Erin Fox, of the University of Utah Health Care.
STAT Plus: Never mind the rebates. Maybe behind-the-scenes fees are boosting drug prices August 16, 2018
The fees constitute a complicated but little-understood piece of the opaque pricing system.
STAT Plus: Pharmalittle: EpiPen shortage may cause back-to-school crisis; Mylan kept mum about a half-million dollar deal August 16, 2018
Good morning, everyone, and how are you today? We are just fine, thank you, especially since a bright, shiny sun and cool breeze are enveloping the Pharmalot campus. Our short…
STAT Plus: As Gilead plans a C-suite succession, the rash of top-level departures continues August 15, 2018
“Lots of their proteges are sharpening their pencils, updating their resumes, and getting ready to leave.”
STAT Plus: Pharmalittle: More turnover at Gilead Sciences; EMA scales back its transparency policy August 15, 2018
The European Medicines Agency scaled back a landmark clinical trial data policy.