cancer Cancer Discovery

Loss of Tight Junction Protein Promotes Development of Precancerous Cells

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer. Understanding how claudin 18 loss occurs and what pathways it regulates may provide new strategies to inhibit neoplastic progression