Ophthalmology

Team from the University of Delaware has found the Protein that Triggers Degradation in the Eye

If you want to take clear photographs, you don't use sandpaper to clear a smudge from your camera's lens. Similarly, if you want to see clearly, the lens of your eye has to be free of obstruction. For that reason a curious thing happens during the development of eye lenses. Instead of closely guarding their nucleus and the DNA it contains - which normal cells do - most lens cells
Gene Therapy

Mass. Eye and Ear Performs First FDA-Approved Gene Therapy Procedure for Inherited Disease

Massachusetts Eye and Ear made medical history this week by performing the first post-FDA approval gene therapy for patients with a form of inherited blindness. The occasion marks the beginning of a new era in medicine, as it is the first time any FDA-approved gene therapy has been given to a patient for any inherited disease. The treatment, commercially identified as Luxturna, was developed by Spark Therapeutics and approved in
Gene Therapy

New gene therapy corrects a form of inherited macular degeneration in canine model

Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degeneration in a canine model. The work sets the stage for translating the findings into a human therapy for an inherited disease that results in a progressive loss of central vision and which is currently untreatable. The study, published today in Proceedings of the National Academy of Sciences, was led by Karina
Gene Therapy

Study advances gene therapy for glaucoma

While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains to control fluid pressure in the eye. Genes can't work until they enter a cell. Glaucoma, one of the most common blinding diseases, is caused by excess pressure inside the eye, usually due to a clog
Ophthalmology

NIH Discovery Brings Stem Cell Therapy for Eye Disease Closer to the Clinic

Scientists at the National Eye Institute (NEI), part of the National Institutes of Health, report that tiny tube-like protrusions called primary cilia on cells of the retinal pigment epithelium (RPE)—a layer of cells in the back of the eye—are essential for the survival of the retina’s light-sensing photoreceptors. The discovery has advanced efforts to make stem cell-derived RPE for transplantation into patients with geographic atrophy, otherwise known as dry age-related
Gene Therapy Genetic Disorders

FDA Panel Approves Gene Therapy For A Form Of Childhood Blindness

An advisory board at the  Food and Drug Administration today endorsed the first gene therapy for an inherited disorder — a rare condition that causes a progressive form of blindness that usually starts in childhood. The recommendation came in a unanimous 16-0 vote after a day full of hearings that included emotional testimonials by doctors, parents of children blinded by the disease and from children and young adults helped by