Cell Therapy

Stem Cell-Derived Neurons Stop Seizures and Improve Cognitive Function

About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs. Even when the drugs do work, people may develop cognitive and memory problems and depression, likely from the combination of the underlying seizure disorder and the drugs to treat it. A team
Biotechnology Clinical Trials Gene Therapy genes

Proof of Concept Study Aims for Rapid Genotyping to Guide Epilepsy Treatment

An easy and inexpensive test for the HLA-B*15:02 allele could one day allow clinicians to quickly identify which epilepsy patients are at risk of carbamazepine hypersensitivity, according to study results presented by Gita V. Soraya at ILAE's 2018 Asian & Oceanian Epilepsy Congress in Bali. “This study has provided the proof of principle evidence for the development of a handheld device that can be used at the clinic or bedside
Neurology

Novel Mechanism Found In a Severe Childhood Neurodegeneration

Neurology researchers investigating a rare but devastating neurological regression in infants have discovered the cause: gene mutations that severely disrupt crucial functions in mitochondria, the energy-producing structures within cells. The specific disease mechanism, in which mutations disrupt a critical mitochondrial enzyme, has not previously been implicated in a human disease. “We uncovered the cause of this mysterious neurodegenerative disease, and now we understand better what happens in the brains of
Biotechnology

A Dietary Supplement Dampens the Brain Hyperexcitability Seen in Seizures or Epilepsy

Seizure disorders — including epilepsy — are associated with pathological hyperexcitability in brain neurons. Unfortunately, there are limited available treatments that can prevent this hyperexcitability. However, University of Alabama at Birmingham researchers have found that inducing a biochemical alteration in brain proteins via the dietary supplement glucosamine was able to rapidly dampen that pathological hyperexcitability in rat and mouse models. These results represent a potentially novel therapeutic target for the treatment of
Biotechnology Neurology Neuroscience Uncategorized

Better ‘Mini Brains’ Could Help Scientists Identify Treatments for Zika-Related Brain Damage

UCLA researchers develop improved technique for creating brain tissue from stem cells UCLA researchers have developed an improved technique for creating simplified human brain tissue from stem cells. Because these so-called “mini brain organoids” mimic human brains in how they grow and develop, they’re vital to studying complex neurological diseases. In a study published in the journal Cell Reports, the researchers used the organoids to better understand how Zika infects and