Cancer Discovery

Stunting cell ‘antennae’ could make cancer drugs work again

Scientists have uncovered a completely new way to make cancers sensitive to treatment - by targeting antenna-like structures on cells. Their study found that drug-resistant cancer cells have more and longer antennae than those which are killed by treatment. Blocking the growth of antennae reactivated a range of cancer treatments that had stopped working, the team at The Institute of Cancer Research, London, found. The researchers identified changes in cellular
cancer Gene Therapy Genomes

Restoring Chemotherapy Sensitivity by Boosting MicroRNA Levels

By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug. If the miRNA molecules can be delivered to cells in the human body – potentially with nanoparticles – the technique might one day be used to battle the chemotherapy resistance that often