Biotechnology Diabetes

Key to Weight Loss in 2019: Don’t Diet: Lose Weight!

The South Bronx is notorious for its high obesity and diabetes rates ---the highest in New York State. But Loretta Fleming, as part of a group of community health educators, is fighting this trend with new success. Loretta, herself, was a diabetic who weighed 378 pounds when she took an intensive course in diabetes self-management offered by the South Bronx community group Health People. In three years, she lost 108
Diabetes Heart Health

Diabetes drug could be used to treat common heart failure syndrome, study suggests

Researchers at the University of Arizona have discovered that metformin, a drug commonly used to treat type 2 diabetes, might also be used to treat heart failure with preserved ejection fraction (HFpEF), a condition that is predicted to affect over 8% of people ages 65 or older by the year 2020. The study, which was published December 19 in the Journal of General Physiology, shows that metformin relaxes a key heart muscle protein
Biotechnology

Next step towards replacement therapy in type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment. This breakthrough published in the journal Nature will facilitate the manufacturing of pancreatic islet cells from stem cells and might help combating type 1 diabetes. Prof. Dr. Henrik Semb who led the study recently joined Helmholtz
Alzheimers and Dementia

Diabetes Medications May Reduce Alzheimer’s Disease Severity, Mount Sinai Researchers Report

People with Alzheimer’s disease who were treated with diabetes drugs showed considerably fewer markers of the disease including abnormal microvasculature and disregulated gene expressions in their brains compared to Alzheimer’s patients  without treatment for diabetes, Mount Sinai researchers report. Results of the study will be published in PLOS One online on November 1st at 2PM. This is the first study to examine what happens in the pathways of both brain tissue and endothelial
Diabetes

Managing High Blood Pressure in Diabetics May Prevent Life-Threatening Organ Damage

The most effective way to prevent life-threatening complications of extreme hypertension in African-Americans with diabetes is to better control their blood pressure, according to a Rutgers study, the largest of its kind. The study, which appears in Clinical and Experimental Hypertension, included 783 diabetic and 1,001 non-diabetic patients from a New Jersey hospital emergency department that serves predominantly African-American communities. It is the first study to look at the risk factors and
Diabetes

Amount of Weight Regain After Bariatric Surgery Helps Predict Health Risks

Measuring the percentage of weight regained following the maximum amount of weight lost after bariatric surgery can help predict a patient’s risk of several serious health problems, according to a long-term, multicenter study led by University of Pittsburgh Graduate School of Public Health researchers. The results, published today in JAMA, also found that, while on average study participants achieved maximum weight loss at two years post-surgery, when they reached that milestone varied substantially,
Biotechnology Cell Therapy Diabetes Pharmaceuticals

Diabetes Drugs Act as Powerful Curb for Immune Cells in Controlling Disease-causing Inflammation

Controlling Immune System Fuel Puts the Brakes on Macrophage Damage When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a common class of drugs used to treat diabetes has been found to exert a powerful
Biotechnology

New Study Could Change the Way We Think about Obesity and Health

[embed]https://www.youtube.com/watch?v=pqTbUUT8JnM&feature=youtu.be[/embed] Researchers at York University's Faculty of Health have found that patients who have metabolic healthy obesity, but no other metabolic risk factors, do not have an increased rate of mortality. The results of this study could impact how we think about obesity and health, says Jennifer Kuk, associate professor at the School of Kinesiology and Health Science, who led the research team at York University. "This is in contrast
Biotechnology Clinical Trials Diabetes

Experimental Drug Stops Parkinson’s Disease Progression in Mice

Johns Hopkins researchers say they have developed an experimental drug, similar to compounds used to treat diabetes, that slows the progression of Parkinson’s disease itself — as well as its symptoms — in mice. In experiments performed with cultures of human brain cells and live mouse models, they report the drug blocked the degradation of brain cells that is the hallmark of Parkinson’s disease. The drug is expected to move
Diabetes

Platypus venom inspires potential new diabetes treatments

The world-first discovery of a key metabolic hormone found in the venom and gut of Australia’s iconic platypus will now be investigated for its potential to treat type 2 diabetes, in new research led by the University of Adelaide. In a collaboration between the University of Adelaide, Flinders University, Monash University, SAHMRI and the Royal Adelaide Hospital, funding from Medvet Science is supporting a study to investigate whether the platypus
Biotechnology Cell Therapy Regenerative Medice

Tissue Engineered Human Pancreas Cells Successfully Treat Diabetic Mice

Self-Condensation Process for Cells Generates Vascularized Organ Tissues for Transplant Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human
Cancer Discovery

High Blood Sugar May Increase Risk for Prostate Cancer Death

Cancer’s sweet tooth may play a role in increasing the risk of lethal prostate cancers, according to researchers at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins Bloomberg School of Public Health. The findings are preliminary results from a review of data collected among more than 5,000 men enrolled in the Atherosclerosis Risk in Communities Study, a prospective national study of heart disease that began in 1987. In
Biotechnology rare diseases

Unexpected Finding May Deter Disabling Diabetic Eye Disease

Diabetic retinopathy is considered one of the most disabling complications of diabetes and the leading cause of new cases of vision loss among adults. A new Michigan State University study is the first to find that a particular type of lipid, or fat, thought to only exist in the skin, now lives in your eye and might play a major role in deterring the eye disease. “Our study presents an
Diabetes

Animal Study Suggests Common Diabetes Drug May Also Help with Nicotine Withdrawal

In a mouse study, a drug that has helped millions of people around the world manage their diabetes might also help people ready to kick their nicotine habits. In a report published this week in The Proceedings of the National Academy of Sciences of the United States of America (PNAS), investigators say metformin, an inexpensive drug commonly used to treat patients with type 2 diabetes, appears to block symptoms of nicotine
Diabetes

Researchers Investigate the Role of Arsenic in the Development of Diabetes

A five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins – found in the human body in 25 different forms – counter the effects of arsenic. Diabetes is a metabolic disease characterized by either a lack of
Biotechnology Diabetes Immunotherapies

Untimely Immune Cell Clocks May Contribute To Obesity And Diabetes In Shift Workers

About 15 million Americans don’t have a typical nine-to-five workday, and many of these—nurses, firefighters and flight attendants, among many other professions—may see their schedule change drastically one week to the next. As a result, these shift workers’ biological clocks, which keep track of the time of day, cannot keep accurate time, potentially making the negative effects of a high fat diet on metabolic disorders even more pronounced, according to new
Diabetes

Kidney Disease Increases Risk of Diabetes, Study Shows Elevated urea levels likely a culprit

Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The nitrogen-containing waste product in blood comes from the breakdown of protein in
Biotechnology Clinical Trials Gene Therapy rare diseases

Scientists make a major breakthrough to treat fibrotic diseases that cause organ failure

Researchers from Duke-NUS Medical School (Duke-NUS) and the National Heart Centre Singapore (NHCS) have discovered that a critical protein, known as interleukin 11 (IL11) is responsible for fibrosis and causes organ damage. While it is surprising that the importance of IL11 has been overlooked and misunderstood for so long, it has now been very clearly demonstrated by this work. A protein known as transforming growth factor beta 12 ("TGFB1") has
Diabetes

A step closer to a cure for adult-onset diabetes

In healthy people, exosomes - tiny structures secreted by cells to allow intercellular communication - prevent clumping of the protein that leads to type 2 diabetes. Exosomes in patients with the disease don't have the same ability. This discovery by a research collaboration between Chalmers University of Technology and Astrazeneca takes us a step closer to a cure for type 2 diabetes. Proteins are the body's workhorses, carrying out all
Biomarkers

Biomarkers Pinpoint the Effects of Thirdhand Smoke on Liver and Lung Found to Worsen Over Time

Researchers at the University of California, Riverside have found that thirdhand-smoke (THS) exposure has a significant effect on health as early as one month after initiation of exposure – an effect that worsens with time. THS results when exhaled smoke and smoke emanating from the tip of burning cigarettes gets on surfaces such as clothing, hair, homes, and cars. THS has been shown, in mice, to cause type 2 diabetes,