Biotechnology

New Breakthroughs Offer Hope for Patients with Cystic Fibrosis to Breathe Easier

Two preliminary trials have found that either of two triple-drug regimens could potentially benefit 90 percent of people with cystic fibrosis. The short-term trials found that the drug combinations improved adult patients' lung function over four weeks. But experts said they were optimistic the results will hold up in the larger, longer-term trials already underway. Researchers point to a  triple-drug approach could open up new options to nearly all cystic
Antibiotics

Triclosan, often maligned, may have a good side — treating cystic fibrosis infections

Antibiotic-resistant bacteria inside a biofilm. Kateryna Kon/Shutterstock.com Chris Waters, Michigan State University Maybe you’ve had the experience of wading in a stream and struggling to keep your balance on the slick rocks, or forgetting to brush your teeth in the morning and feeling a slimy coating in your mouth. These are examples of bacterial biofilms that are found anywhere a surface is exposed to bacteria in a moist environment. Besides
Biotechnology

Queen’s Research Discovers Vitamins Could Help Treat Cystic Fibrosis

Researchers from Queen’s University Belfast have discovered why antibiotics for treating people with cystic fibrosis are becoming less effective and how fat soluble vitamins might offer a viable solution. A team of researchers led by Professor Miguel Valvano, from the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University Belfast, has discovered why some particularly harmful bacteria are not responding to antibiotics. The bacteria, Burkholderia cenocepacia, are highly antibiotic resistant and
Biotechnology Clinical Trials

University Hospitals Rainbow Babies & Children’s Hospital Opens First Stem Cell Study in Patients with Cystic Fibrosis

Study is first step toward goal of developing therapy to quell CF’s lung inflammation A 39-year-old man with cystic fibrosis (CF) made history by becoming the first person to receive human adult stem cells in a new research study that researchers hope will someday lead to the development of a therapy to reduce the inflammation and infection caused by CF. The pioneering subject in the study is Bob Held from
Biotechnology rare diseases

Bacterial ‘Sabotage’ Handicaps Ability to Resolve Devastating Lung Inflammation in Cystic Fibrosis

The chronic lung inflammation that is a hallmark of cystic fibrosis, has, for the first time, been linked to a new class of bacterial enzymes that hijack the patient’s immune response and prevent the body from calling off runaway inflammation, according to a laboratory investigation led by the University of Pittsburgh School of Medicine. The discovery, published today by the Proceedings of the National Academy of Sciences, gives scientists two