Scientists build a new model of CAR-T cells — Ones with Powerful “Armor” that allow them to fight Solid Tumors
Engineered T-cell therapy, and in particular CAR T-cells, have shown efficacy in CD-19+ blood cancer such as lymphomas and leukemias. However, to date, T-cell therapies have found little success in solid tumors – in part due to the immunosuppressive tumor microenvironment. Checkpoint inhibitors, on the other hand, have been proven effective at empowering the immune system to fight a variety of solid tumors. The checkpoint inhibitor antibody binds to a
