cancer Cancer Discovery

Simultaneous Chemotherapy and Immunotherapy May Be Better for Some Metastatic Bladder Cancer Patients

Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond particularly well to this combination approach, according to the results of a clinical trial published in European […]

Biotechnology

Tibetan Yoga Practice May Improve Sleep Quality for Breast Cancer Patients Receiving Chemotherapy

Participating in twice-weekly practice of Tibetan yoga may reduce sleep disturbances and improve sleep quality in breast cancer patients receiving chemotherapy, according to a study from researchers at The University of Texas MD Anderson Cancer Center. The research, published in the journal Cancer, found that women who practiced Tibetan yoga at least two times a week reported less […]

Biotechnology

Immunotherapy for Glioblastoma Well Tolerated; Survival Gains Observed

A phase one study of 11 patients with glioblastoma who received injections of an investigational vaccine therapy and an approved chemotherapy showed the combination to be well tolerated while also resulting in unexpectedly significant survival increases, researchers at the Duke Cancer Institute report. Patients treated with the study drug (dose-intensified temozolomide and vaccines) were continuously […]

cancer

Scientists Identify Chain Reaction That Shields Breast Cancer Stem Cells From Chemotherapy

Working with human breast cancer cells and mice, researchers at Johns Hopkins say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after chemotherapy. The regrowth of cancer stem cells is responsible for the drug resistance that develops in many breast tumors and the reason that for many patients, […]

Biotechnology cancer

In Highly Lethal Type Of Leukemia, Cancer Gene Predicts Treatment Response

Patients whose cancer cells carry TP53 mutations respond to milder chemotherapy Patients with the most lethal form of acute myeloid leukemia (AML) – based on genetic profiles of their cancers – typically survive for only four to six months after diagnosis, even with aggressive chemotherapy. But new research indicates that such patients, paradoxically, may live […]

Biotechnology

Study Shows Low-Dose Chemotherapy Regimens Could Prevent Tumor Recurrence In Types Of Breast Cancer And Pancreatic Cancer

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors’ recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered. Frequent, low-dose chemotherapy regimens avoid this effect and may therefore […]

cancer Cell Therapy Immunotherapies

JCAR014 Clinical Data Published In Science Translational Medicine: Patients With Advanced Lymphoma In Remission After T-Cell Therapy

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy. CAR T cells are made from a patient’s own immune cells that are […]

Biomarkers cancer

Study Finds Potential New Biomarker for Cancer Patient Prognosis

To treat or not to treat? That is the question researchers at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) hope to answer with a new advance that could help doctors and their cancer patients decide if a particular therapy would be worth pursuing. Berkeley Lab researchers identified 14 genes regulating genome integrity […]