cancer Cancer Discovery

Researchers Uncover New Target to Stop Cancer Growth

Researchers at the University of Wisconsin-Madison have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes—tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study, which will be published June 21 in the Journal of Cell Biology, could lead to new therapies that stop tumor growth and metastasis by […]

cancer Cancer Discovery Clinical Trials

Seattle Children’s Opens Immunotherapy Trial For Children With Relapsed Central Nervous System Tumors That Delivers CAR T Cells Directly Into the Brain

CAR T-cell immunotherapy targeting HER2 protein on cancer cells aims to provide children and young adults who have limited treatment options with a second line of defense Seattle Children’s has opened a pioneering chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory HER2-positive central nervous system (CNS) tumors […]

cancer Cancer Discovery

Temple University Scientists Eradicate Cancer Cells Through Dual Targeting of DNA Repair Mechanisms

Proteins commonly known as BRCA – short for BReast CAncer susceptibility gene– serve a critical role in cellular DNA repair, but when mutated they allow genetic errors to replicate, facilitating cancer development. If the BRCA repair system is disabled in cancer cells, the cells simply turn to backup repair mechanisms and adapt to alternative repair […]

cancer Cancer Discovery

Camouflaged Nanoparticles Used to Deliver Killer Protein to Cancer

A team of Penn State researchers has developed a biomimetic nanosystem to deliver therapeutic proteins to selectively target cancerous tumors. Using a protein toxin from a plant found in the Himalayan mountains, called gelonin, the researchers caged the proteins in self-assembled metal-organic framework (MOF) nanoparticles to protect them from the body’s immune system. To enhance […]

Cell Therapy

New Target for Treating Heart Failure Identified by Penn Medicine Researchers

Changes in cellular struts called microtubules (MT) can affect the stiffness of diseased human heart muscle cells, and reversing these modifications can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure, found researchers from the Perelman School of Medicine at the University of Pennsylvania. This Nature […]

cancer Cancer Discovery

A Cascade of Immune Processes Offers Insights to Triple-Negative Breast Cancer

Cancer is crafty. To survive and thrive, tumors find a way of thwarting our body’s natural systems. By looking at these systems, researchers at the University of Michigan Rogel Cancer Center have discovered that tumor cells reprogram metabolic pathways to gain control over a type of immune cell that allows cancer growth. Myeloid-derived suppressor cells live in […]

cancer Cancer Discovery

By Forming Clots in Tumors, Immune Cell AIDS Lung Cancer’s Spread

University of North Carolina Lineberger Comprehensive Cancer Center researchers have found that helping to to form clots within tumors, immune cells that flock to a particular type of lung cancer are actually building a foundation for the tumor to spread within the body. In the journal Nature Communications, researchers report for a particular subset of […]

Biotechnology

Scientists Develop Method to Tweak Tiny ‘Antenna’ on Cells

Scientists at Johns Hopkins Medicine and the National Tsing Hua University in Taiwan say they have found a fast way to manipulate a cell’s cilia, the tiny, fingerlike protrusions that “feel” and sense their microscopic environment. The experiments, performed in mouse cells, may advance scientists’ efforts to not only understand how the nanosized antennae work, […]

cancer Cancer Discovery

Early Skin Cancer More Accurately Diagnosed by Dermatologist Than Other Providers

Physician assistants (PAs) are increasingly used in dermatology practices to cut costs and improve access to care, but are more likely than dermatologists to perform unnecessary skin biopsies to check for cancer, while being less likely to accurately diagnose early stage skin cancers, according to new research conducted by the University of Pittsburgh School of Medicine. […]

Cardiology Strokes

Largest-Ever Genetic Study of Stroke Provides New Insight Into the Disease

An international research group, including scientists at the University of Maryland School of Medicine, studying 520,000 people from around the world has identified 22 new genetic risk factors for stroke, tripling the number of gene regions known to affect stroke risk. The results show that stroke shares genetic influences with other vascular conditions, especially blood […]

stem cells

Stem Cell Therapy May Help Reverse Effects of Premature Menopause, Restore Fertility

Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in […]

cancer Cancer Discovery

Improved Capture of Cancer Cells Could Aid in Disease Tracking

Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center and University of Wisconsin-Madison have demonstrated improved methods of capturing free-floating cancer cells that are cast-off from tumors, and circulating in the blood. If these cast-off cells can be accurately counted, they could provide an additional way to track treatment or screen for disease. […]