Biotechnology Clinical Trials

No cardiovascular disease reduction with intensive blood pressure lowering treatment

Blood pressure lowering treatment does not reduce death or cardiovascular disease in healthy individuals with a systolic blood pressure below 140. This is shown in a systematic review and meta-analysis from Umeå University. The results, published in JAMA Internal Medicine, support current guidelines and contradict the findings from the Systolic Blood Pressure Intervention Trial (SPRINT). Blood pressure treatment goals have been intensively debated since the publication of the SPRINT study
Biotechnology

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface. This finding may help researchers create more effective ways to avoid activating the immune system and more precisely direct therapies in patients. In the journal ACS Nano, the team of nanomedicine and regenerative medicine scientists recently described how specially-engineered nanoparticles (leukosomes) injected into mice can prevent
Cardiology

With $8.6 Million Grant From Nih, UCLA-Led Consortium Will Map the Heart’s Nervous System

A consortium directed by UCLA’s Dr. Kalyanam Shivkumar has received a three-year, $8.6 million grant from the National Institutes of Health to map the heart’s nervous system. The group’s goal: To conduct research that leads to new ways to treat cardiovascular disease by targeting nerves in the heart’s nervous system. More than 800,000 people in the U.S. die each year from cardiovascular diseases such as heart failure, arrhythmia and hypertension.
Cardiology Cell Therapy

Scientists Find Culprit Responsible For Calcified Blood Vessels In Kidney Disease

Scientists have implicated a type of stem cell in the calcification of blood vessels that is common in patients with chronic kidney disease. The research will guide future studies into ways to block minerals from building up inside blood vessels and exacerbating atherosclerosis, the hardening of the arteries. The study, led by researchers at Washington University School of Medicine in St. Louis, appears Sept. 8 in the journal Cell Stem