Breast Cancer cancer Cancer Discovery Cancer screening

Researchers Identify a New Way to Determine Whether Metastatic Cancer Cells in Breast Cancer Patients are Dormant or Soon to Turn Deadly

For the first time ever, Mount Sinai researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a reoccurrence of lethal, metastatic cancer, according to a clinical study published in Breast Cancer Research in October. The researchers found that when cells from a breast cancer patient’s original tumor metastasized into […]

Breast Cancer cancer

Innovative regional anesthesia technique reduces pain, opioid use after mastectomy for breast cancer

Women undergoing mastectomy for breast cancer experience improved postsurgical pain relief and reduced opioid consumption when given a pectoralis nerve plane (PECS) block prior to surgery, suggests research presented at the ANESTHESIOLOGY® 2018 annual meeting. The PECS block is a newer regional anesthesia technique that works by injecting long-acting anesthetics, guided by ultrasound, to numb the front […]

Breast Cancer cancer Cancer Discovery

New Study Shows Promise for Targeting Breast Cancer Metastasis

 A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as collagen XIII could be key for suppressing breast cancer metastasis. Breast cancers begin in the epithelial cells, which are the cells that line organs and tissues in the body. Generally, most epithelial cells will die after detaching from their […]

cancer Clinical Trials drug development Surgery

Neoadjuvant Combination Checkpoint Blockade Trial Yields High Response Rates for Patients with High-Risk Stage 3 Melanoma

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early. The phase II study was led by researchers at The University of […]

Biotechnology

Johns Hopkins Grant Project Looks at Small Cell Lung Cancer Treatment Resistances

 Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation). The National Institutes of Health awarded the grant to researchers from The Johns Hopkins University, co-led by Luigi Marchionni, M.D., Ph.D., assistant professor of […]

cancer Cancer Discovery

New Drug Blocks Pancreatic Cancer Growth in Mice, Study Finds

A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study, published recently in the journal Gastroenterology, also demonstrated in mice that the drug, called Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer […]

Biotechnology

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and […]

cancer Cancer Discovery

Queen’s Researchers Discover Ground-Breaking Process Which Destroys Bowel Cancer Cells

Researchers at Queen’s University Belfast have discovered a ground-breaking therapeutic process that can target and kill bowel cancer cells, which may improve survival rates for bowel cancer patients globally. The research, which has been published in the prestigious journal of Molecular Cancer Therapeutics, is deemed the first of its kind with the discovery of a novel treatment […]

cancer Cancer Discovery

New Test Uncovers Metabolic Vulnerabilities in Kidney Cancer

 In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention. Kidney cancer is one of the […]

cancer Cancer Discovery Immunotherapies

Discovery Could Lead to Higher Response Rates for Bladder Cancer Patients Treated with Immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors. In a study published in August in Nature […]

Breast Cancer cancer Cancer Discovery Clinical Trials

Researchers to Test Novel Drug Combination Against Toughest Breast Cancers

Phase I clinical trial will combine standard chemotherapy with cirmtuzumab, a drug that has shown promise against a variety of cancer types Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or […]

cancer Cancer Discovery

Removing the Most Common p53 Mutation in Colorectal Cancer Halts Disease Progression

A Stony Brook pathologist and colleagues publish findings in Cancer Cell By genetically manipulating and removing the most common mutant form of the p53 gene that promotes colorectal cancer in humans, an international team of scientists demonstrated that this therapy reduces tumor growth and tissue invasion. Led by Ute Moll, MD, Professor and cancer biologist in […]

Biotechnology cancer Neurodegenerative diseases

FDA approves treatment for two rare types of non-Hodgkin lymphoma

The U.S. Food and Drug Administration today approved Poteligeo (mogamulizumab-kpkc) injection for intravenous use for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. This approval provides a new treatment option for patients with MF and is the first FDA approval […]

cancer Immunotherapies

First In-Human Clinical Trial Targeting CD4 Protein for Aggressive T-cell Leukemia and Lymphoma to be Launched

Stony Brook University, iCell Gene Therapeutics, and the University of Louisville, have received Food and Drug Administration (FDA) clearance for an Investigational New Drug (IND) for the treatment of relapsed and refractory T-cell leukemia and lymphoma. The approach is the first to use chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR). […]

Biotechnology

NUS and Harvard scientists develop novel drug that could potentially treat liver cancer more effectively

 A research team led by scientists from the Cancer Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma (HCC) or primary liver cancer. This landmark discovery opens door for more effective treatment of liver cancer […]

cancer Cancer Discovery

Foundation for the National Institutes of Health and Cancer Research Institute Announce New Collaboration in Cancer Immunotherapy

The Foundation for the National Institutes of Health (FNIH) and the Cancer Research Institute (CRI) announced today that FNIH has selected CRI to be its source of landscape intelligence in immuno-oncology, also called cancer immunotherapy. This collaboration draws on CRI’s 65 years of leadership in cancer immunotherapy and its first-in-class immunotherapy landscape analyses produced by […]

cancer Cancer Discovery

“Hijacked” Cell Response to Stress Reveals Promising Drug Targets for Blood Cancer

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows. The discovery that the NOTCH1 pathway takes control of heat shock transcription factor 1 (HSF1) signaling in T cell acute lymphoblastic leukemia, or […]