Biotechnology cancer Immunotherapies

Tumor Mutational Burden and Response to Immune Checkpoint Therapy

Predicting how patients will respond to anti-cancer therapies can be vital in informing clinical decisions and improving treatment outcome.  Researchers at Rutgers Cancer Institute of New Jersey examined an association between mutational burden and response to immune checkpoint therapy in several cancer types and found that a mutational burden threshold exists in eight cancers that […]

Biotechnology

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface. This finding may help researchers create more effective ways to avoid activating the immune system and more precisely direct therapies in patients. In the journal ACS Nano, the team of nanomedicine […]