Cancer Discovery

How signals get inside cancer cells and spur aggressive growth

The outside of a cancer cell is bombarded by signals. They come from the immune system, supporting tissues and other structures. But how do those signals impact cancer? A new study provides a surprising model of the process by which those signals enter and influence the cell. The finding could open up a potential new avenue to pursue new therapies against cancer. "How those signals enter the inside of the
Biotechnology cancer Immunotherapies

Tumor Mutational Burden and Response to Immune Checkpoint Therapy

Predicting how patients will respond to anti-cancer therapies can be vital in informing clinical decisions and improving treatment outcome.  Researchers at Rutgers Cancer Institute of New Jersey examined an association between mutational burden and response to immune checkpoint therapy in several cancer types and found that a mutational burden threshold exists in eight cancers that predict response to an immune checkpoint blockade. The work’s co-corresponding authors Shridar Ganesan, MD, PhD,
Biotechnology

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface. This finding may help researchers create more effective ways to avoid activating the immune system and more precisely direct therapies in patients. In the journal ACS Nano, the team of nanomedicine and regenerative medicine scientists recently described how specially-engineered nanoparticles (leukosomes) injected into mice can prevent