Biotechnology

Promising New Targeted Therapy for Acceleration of Bone Fracture Repair

 There are over six million fractures per year in the U.S. with direct costs in the billions, not to mention lost productivity.  The only drug currently available to accelerate the healing process must be applied directly onto the fracture surface during surgery, but not all breaks require such intervention. New research, Bone Fracture-Targeted Dasatinib Conjugate Potently Enhances Fracture Repair In Vivo, presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Meeting highlights a novel
Arthritis

New Assay May Lead to a Cure for Debilitating Inflammatory Joint Disease

Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses, according to research conducted at NYU Langone Medical Center and the University of Pittsburgh. Known as autoantibodies and produced by the immune system’s B cells, these defective molecules mistakenly attack the body's own proteins in an example of autoimmune disease. Now the results of a
Arthritis

The Search for Better Bone Replacement: 3-D Printed Bone with Just the Right Mix of Ingredients

To make a good framework for filling in missing bone, mix at least 30 percent pulverized natural bone with some special man-made plastic and create the needed shape with a 3-D printer. That’s the recipe for success reported by researchers at The Johns Hopkins University in a paper published April 18 online in ACS Biomaterials Science & Engineering. Each year, the Johns Hopkins scientists say, birth defects, trauma or surgery
Biotechnology rare diseases

Drug Candidate Stops Extra Bone Growth in Animal Model of Rare, Genetic Disease

New preclinical research provides support to a drug that has been repurposed to possibly treat a rare and extremely disabling genetic bone disease, particularly in children. In that disease, fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, alters skeletal bone formation, and limits motion, breathing, and swallowing, among a host of progressive symptoms. The research appeared online in the Journal of Bone and Mineral Research (JBMR) ahead