Biotechnology Cell Therapy Immunotherapies Uncategorized

Potential new approach to the treatment of multiple sclerosis

A prospective new method of treating patients with multiple sclerosis has been proposed by researchers of the Mainz University Medical Center working in cooperation with researchers of the University of Montreal. In model trials and experiments employing human endothelial cells, they discovered that the EGFL7 protein hinders the migration of immune cells into the central […]

Biotechnology Cell Therapy Clinical Trials Gene Therapy Immunotherapies Infectious Diseases Vaccines

New molecule shows promise in HIV vaccine design

Researchers at the University of Maryland and Duke University have designed a novel protein-sugar vaccine candidate that, in an animal model, stimulated an immune response against sugars that form a protective shield around HIV. The molecule could one day become part of a successful HIV vaccine. “An obstacle to creating an effective HIV vaccine is […]

Biotechnology cancer Cell Therapy Gene Therapy

Insights from a rare genetic disease may help treat multiple myeloma

A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. Now scientists, reporting in ACS Central Science, have found that insights into a rare genetic disease known as NGLY1 deficiency […]

Biotechnology Gene Therapy Pharmaceuticals rare diseases

MDI Biological Laboratory study finds immune system is critical to regeneration

The answer to regenerative medicine’s most compelling question — why some organisms can regenerate major body parts such as hearts and limbs while others, such as humans, cannot — may lie with the body’s innate immune system, according to a new study of heart regeneration in the axolotl, or Mexican salamander, an organism that takes […]

Alzheimers and Dementia Neurology

Stabilizing TREM2 — a potential strategy to combat Alzheimer’s disease

A gene called triggering receptor expressed on myeloid cells 2, or TREM2, has been associated with numerous neurodegenerative diseases, such as Alzheimer’s disease, Frontotemporal lobar degeneration, Parkinson’s disease, and Nasu-Hakola disease. Recently, a rare mutation in the gene has been shown to increase the risk for developing Alzheimer’s disease. Independently from each other, two research […]

Biotechnology cancer

Wistar scientists develop novel immunotherapy technology for prostate cancer

A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific protein. This is the first application of the new technology, called DNA-encoded monoclonal antibody (DMAb), for cancer immunotherapy. The study […]

Biotechnology cancer Gene Therapy

Skewing the aim of targeted cancer therapies

Headlines, of late, have touted the successes of targeted gene-based cancer therapies, such as immunotherapies, but, unfortunately, also their failures. Broad inadequacies in a widespread biological concept that affects cancer research could be significantly deflecting the aim of such targeted drugs, according to a new study. A team exploring genetic mechanisms in cancer at the […]

Biotechnology cancer

Cell mechanism discovery could lead to ‘fundamental’ change in leukaemia treatment

Researchers have identified a new cell mechanism that could lead to a fundamental change in the diagnosis and treatment of leukaemia. A team in the University of Kent’s pharmacy school conducted a study that discovered that leukaemia cells release a protein, known as galctin-9, that prevents a patient’s own immune system from killing cancerous blood […]

Biotechnology

Epilepsy drug therapies to be improved by new targeted approach

New research from the University of Liverpool, in collaboration with the Mario Negri Institute in Milan, published today in the Journal of Clinical Investigation, has identified a protein that could help patients with epilepsy respond more positively to drug therapies. Epilepsy continues to be a serious health problem and is the most common serious neurological […]

cancer Cancer Discovery Cell Therapy Vaccines

UMN researchers find distinct differences in structure, features of retroviruses

In the most comprehensive study of its kind, researchers in the Institute for Molecular Virology and School of Dentistry at the University of Minnesota report that most types of retroviruses have distinct, non-identical virus structures. Researchers analyzed seven different retroviruses including two types of HIV as well as HTLV-1, a virus that causes T-cell leukemia. […]

Genomes

Get a clue: Biochemist studies fruit fly to understand Parkinson’s disease, muscle wasting

The fruit fly may help us be less clueless about human muscle development and Parkinson’s disease. Erika Geisbrecht, Kansas State University associate professor of biochemistry and molecular biophysics, is studying the fruit fly, or Drosophila melanogaster, to understand a gene called clueless, or clu. Geisbrecht and her research team have found a connection between clu […]

cancer Cancer Discovery Diagnostic Testing

No symptoms, but could there be cancer? Our chemosensor will detect it!

Many cancers could be successfully treated if the patient consulted the doctor sufficiently early. But how can a developing cancer be detected if it doesn’t give rise to any symptoms? In the near future, suitably early diagnosis could be provided by simple and cheap chemical sensors – thanks to special recognizing polymer films developed at […]

Gene Therapy Genomes

Genetic Variations that Boost PKC Enzyme Contribute to Alzheimer’s Disease

In Alzheimer’s disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons. Now, researchers at University of California San Diego School of Medicine and Harvard Medical School have found that the enzyme Protein Kinase C (PKC) alpha is necessary for amyloid beta to damage neuronal connections. They also identified genetic variations […]