Immunotherapies

Harnessing Hair Loss Gene Could Improve Cancer Immunotherapy

A gene that’s associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy, suggests a new mouse study by Columbia University Irving Medical Center (CUIMC) researchers. The paper was published recently in the journal Cell Systems. “While immunotherapies have shown great promise in cancer, most patients do not benefit from these […]

Biotechnology

Tailoring Nanoparticles to Evade Immune Cells and Prevent Inflammatory Response

A Houston Methodist-led research team showed that the systemic administration of nanoparticles triggers an inflammatory response because of blood components accumulating on their surface. This finding may help researchers create more effective ways to avoid activating the immune system and more precisely direct therapies in patients. In the journal ACS Nano, the team of nanomedicine […]

Arthritis

New Assay May Lead to a Cure for Debilitating Inflammatory Joint Disease

Current treatments for rheumatoid arthritis relieve the inflammation that leads to joint destruction, but the immunologic defect that triggers the inflammation persists to cause relapses, according to research conducted at NYU Langone Medical Center and the University of Pittsburgh. Known as autoantibodies and produced by the immune system’s B cells, these defective molecules mistakenly attack […]

Biotechnology

Stressed Out Interferons Reveal Potential Key to Alternative Lupus Treatment

Only one new drug has become available over the past 50 years for the estimated 1.5 million Americans and five million-plus people worldwide suffering from lupus, but new research has identified a previously unknown mechanism involved in the immune response that could provide an alternative therapy target. Lupus (also known as systemic lupus erythematosus) is […]

Biotechnology

Mayo Clinic Researchers Find Association Between Therapy for Autoimmune Disease and Bone Marrow Disorders

Mayo Clinic researchers have found that azathioprine, a drug commonly used to treat autoimmune disease, may increase the risk of myeloid neoplasms. Myeloid neoplasms include a spectrum of potentially life-threatening bone marrow disorders, such as myelodysplastic syndromes and acute myeloid leukemia. The results are published in JAMA Oncology. Researchers analyzed more than 40,000 patient cases […]

Biotechnology Cell Therapy rare diseases

Researchers Discover a New Gatekeeper Role for Thymic Dendritic Cells in Controlling T Cell Release into the Bloodstream

Better Understanding of Cell’s Role Could Lead to New Strategies to Treat Autoimmune Diseases, Cancer Newswise — Oakland, CA (December 6, 2016) – A team of scientists led by Julie Saba, MD, PhD at UCSF Benioff Children’s Hospital Oakland, has unveiled a novel role of thymic dendritic cells, which could result in new strategies to […]

Biotechnology Clinical Trials Gene Therapy Genetic Disorders Immunotherapies

Successfully Treating Genetically Determined Autoimmune Enteritis

Using targeted immunotherapy, doctors have succeeded in curing a type of autoimmune enteritis caused by a recently discovered genetic mutation. This report comes from researchers at the Department of Biomedicine of the University of Basel and University Hospital Basel. Their results raise new possibilities for the management of diarrhea, which is often a side effect […]

Diabetes rare diseases

New Data From Harvard & Yale Researchers Reveal Breakthrough Oral Fully Human Anti-CD3 Antibody, for the Treatment of NASH, Diabetes & Autoimmune Diseases

Immunotherapies have shown great promise to treat a wide range of diseases including auto-immune disease and NASH. However, they are typically administered through IV instead of orally because if taken orally, they would be degraded and inactivated by the harsh conditions in the gastrointestinal tract. New data from preclinical studies conducted by Prof. Kevan Herold […]

Biotechnology Immunotherapies

Flesh-Eating Infections In Rheumatoid Arthritis Patients Spur New Discovery

Rheumatoid arthritis patients taking medications that inhibit interleukin-1beta (IL-1beta), a molecule that stimulates the immune system, are 300 times more likely to experience invasive Group A Streptococcal infections than patients not on the drug, according to University of California San Diego School of Medicine researchers. Their study, published August 19 in Science Immunology, also uncovers […]

rare diseases

New Research Studies Identify Potential Cause of and New Treatment for Autoimmune Diseases

The American Autoimmune Related Diseases Association, Inc. (AARDA) is spotlighting two new research studies originally reported in ScienceDaily. The first study advances understanding of a potential cause of autoimmune disease, while the second examines a new treatment approach that could have wide-ranging implications for many autoimmune diseases. In both cases, AARDA believes the research is […]