age-related decline

Thyroid Gene Variation May Increase Risk for Alzheimer’s Disease in African Americans

African Americans with a common genetic variation are at increased risk for developing Alzheimer’s disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. They published the study results in the February 22 online issue of the Journal of Clinical Endocrinology and Metabolism. […]

age-related decline Alzheimers and Dementia

A New Therapeutic Avenue for Parkinson’s disease

Systemic clearing of senescent astrocytes prevents Parkinson’s neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers in the Andersen lab at the Buck Institute provide a new potential therapeutic avenue for the incurable, progressive neurological disorder that affects up to one […]

Alzheimers and Dementia amyotrophic lateral sclerosis Biotechnology

New drug therapy could improve brain function and life expectancy of ALS patients

Ben-Gurion University of the Negev (BGU) researchers are developing a new therapy for Amyotrophic Lateral Sclerosis (ALS) using part of an existing FDA-approved drug that restores the central nervous system’s (CNS) immune defenses and increases life expectancy. ALS, also known as Lou Gehrig’s disease, is a lethal, progressive neurodegenerative disorder that affects the motor nerve […]

Alzheimers and Dementia

Researchers Identify How Inflammation Spreads Through the Brain After Injury

Findings Could Transform How Understanding of Brain Injury and Disease Researchers have identified a new mechanism by which inflammation can spread throughout the brain after injury. This mechanism may explain the widespread and long-lasting inflammation that occurs after traumatic brain injury, and may play a role in other neurodegenerative diseases. The findings were published today […]

Alzheimers and Dementia

New Understandings of Cell Death Show Promise for Preventing Alzheimer’s

New research on peptides important to understanding Alzheimer’s disease and their effects on cell toxicity could lead to treatments for preventing or delaying neurodegenerative diseases Alzheimer’s disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. A person with Alzheimer’s disease suffers loss of control over thought, memory and […]

Neurodegenerative diseases

Scientists keep a molecule from moving inside nerve cells to prevent cell death

Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe. The cellular mechanisms behind ALS are also found in certain types of dementia. A groundbreaking scientific […]

Alzheimers and Dementia

Penn Medicine Team and Collaborators Receive NIH Award to Launch Genomics Center on Alzheimer’s Disease

A five-year, projected $10.8 million award from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), will establish the Coordinating Center for Genetics and Genomics of Alzheimer’s Disease, a joint venture of researchers from the Perelman School of Medicine at the University of Pennsylvania and five other institutions. Penn will […]