age-related decline Alzheimers and Dementia

Scientists Propose a New Lead for Alzheimer’s Research

A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer’s disease, which could provide new avenues for future research. In a paper published in the journal Frontiers in Neuroscience, the team proposes a new theory for how rare gene mutations cause Alzheimer’s […]

Pharmaceutical Business News

Celgene Partners with Prothena Therapeutics in Potential $2B Deal

(BioSpace) Shares of Prothena Corporation plc have shot up more than 18 percent in premarket trading this morning after the company forged a collaboration with pharma giant Celgene to develop new therapies for a broad range of neurodegenerative diseases, including Alzheimer’s and ALS. Celgene will pay Prothena $150 million in upfront money with the promise […]

Alzheimers and Dementia

New Player in Alzheimer’s Disease Pathogenesis Identified

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease. “Our […]

Alzheimers and Dementia Biotechnology

Alzheimer’s disease study links brain health and physical activity

People at risk for Alzheimer’s disease who do more moderate-intensity physical activity, but not light-intensity physical activity, are more likely to have healthy patterns of glucose metabolism in their brain, according to a new UW-Madison study. Results of the research were published today online in Journal of Alzheimer’s Disease. Senior author Dr. Ozioma Okonkwo, assistant […]

Alzheimers and Dementia

New Understandings of Cell Death Show Promise for Preventing Alzheimer’s

New research on peptides important to understanding Alzheimer’s disease and their effects on cell toxicity could lead to treatments for preventing or delaying neurodegenerative diseases Alzheimer’s disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. A person with Alzheimer’s disease suffers loss of control over thought, memory and […]

Alzheimers and Dementia Biotechnology

Weston Brain Institute Funds Clinical Trials of New Alzheimer’s Treatment

Electrocranial stimulation offers hope for Alzheimer’s patients Funding for clinical trials of a new treatment for Alzheimer’s disease has been announced by the Weston Brain Institute. Dr. Zahra Moussavi, Canada Research Chair in Biomedical Engineering in the Faculty of Engineering, is receiving $1,737,960 for her project on investigating the efficacy of high-frequency rTMS treatment for […]

Alzheimers and Dementia Genomes Neurodegenerative diseases Neurology

Genetic ‘Switch’ Identified As Potential Target For Alzheimer’S Disease

A team at the MRC Clinical Sciences Centre (CSC), based at Imperial College London, has found an important part of the machinery that switches on a gene known to protect against Alzheimer’s Disease. Working in collaboration with scientists at the Hong Kong University (HKU) and the Erasmus University in Rotterdam, CSC associate professor Richard Festenstein […]

Alzheimers and Dementia

Vesicles That Trap Amyloid Appear to Also Contribute to Alzheimer’s Disease

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer’s, appear to also contribute to the disease, scientists report. Reducing the production of these vesicles, called exosomes, could help reduce the amount of amyloid and lipid that accumulates, slow disease progression and help protect cognition, scientists at the Medical College of […]

Alzheimers and Dementia

Understanding How Chemical Changes in the Brain Affect Alzheimer’s Disease

A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine – a target for anticholinergic drugs – […]