Patient, Human Face, Brazil, Asthmatic, Child

Enzyme May Represent New Target for Treating Asthma

An enzyme called diacylglycerol kinase zeta (DGKζ) appears to play an important role in suppressing runaway inflammation in asthma and may represent a novel therapeutic target, according to research presented at ATS 2019. The researchers deleted the enzyme in mouse T cells, which drive the immune system, and found that both inflammation and airway hyper-responsiveness, two hallmarks of asthma, were reduced through independent biomolecular mechanisms.

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