Data recently obtained from Nemus Bioscience‘s research and development partner, the University of Mississippi (UM) will show the superiority of the NEMUS proprietary analogue of CBD, NB2222, versus plant-derived CBD in ameliorating pain in a validated mouse (murine) model of chemotherapy-induced peripheral neuropathy using an opioid as an active comparator. The data was accepted for a presentation at the 2017 Annual Meeting of the Society of Neuroscience to held in Washington, D.C. on November 11th-15th.
Additional data will also detail the anti-addictive potential of NB2222 in an animal model of opioid addiction. The in vivo research was led by Professor Kenneth Sufka of the University of Mississippi based on the molecular cannabinoid discovery work performed by the team at ElSohly Laboratories, Inc. (ELI) in collaboration with the University, spearheaded by Dr. Mahmoud ElSohly, who also holds a faculty appointment at the University.
“NEMUS has previously reported that our proprietary analogue of CBD, NB2222, has exhibited a competitive bioavailability profile when compared to plant-derived CBD, penetrating the blood-brain barrier to enter the central nervous system, as well as all major organs, especially the liver, in animal studies conducted to-date,” commented Brian Murphy, MD, MBA, the NEMUS CEO and Chief Medical Officer. “The data being presented by Dr. Sufka is a pivotal start to developing the analogue of CBD to potentially address medical indications in multiple organ systems, especially the eye, brain and diseases of the liver.”
Dr. Kenneth Sufka, professor of Psychology and Pharmacology and Research Professor with the National Center for Natural Products Research at UM stated, “We have been able to demonstrate that NB2222 was able to deliver analgesia comparable to morphine, which has been implicated in the current global opioid abuse epidemic. The research team then moved to the next step using a validated animal model of addiction to opioids to assess the anti-abuse potential of NB2222 as a therapeutic. We look forward to presenting the data this fall.”
“The discovery team is very pleased with the performance of this analogue of CBD in the studies that have been performed so far,” reported Dr. Mahmoud ElSohly, professor at the National Center for Natural Products Research at the University of Mississippi School of Pharmacy and co-inventor of the CBD analogue. “We believe that bio-engineered cannabinoids offer a unique opportunity to potentially enhance the efficacy and safety profile of this class of therapeutics. We look forward to working with NEMUS in advancing other cannabinoid-based therapies across a spectrum of diseases.”
Dr. Murphy noted, “It appears that NB2222 could have a number of uses beyond pain management and ocular conditions, and moving forward, Nemus will consider strategic collaborations for this CBD analogue.”