Biotechnology Regenerative Medice stem cells

New Technique Uses Umbilical Cord Stem Cells for Early Repair of Cleft Palate

A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.  Performed as part of reconstructive surgery when the infant is a few months old, the stem cell procedure provides good results in growing new bone to close the upper […]

Biotechnology Clinical Trials stem cells

Human Neural Stem Cells Drive Spine Regeneration in Rats

Stem cells maintained in culture renewed long regions of spinal cord in rat transplant model NIBIB-funded researchers generated stable lines of spinal cord neural stem cells in a laboratory dish. Once transplanted into a rat model of spinal cord injury, the cells enabled robust regeneration of functional neurons along the length of the spine. The […]

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Stem Cell Therapy May Help Reverse Effects of Premature Menopause, Restore Fertility

Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in […]

Biotechnology Cell Therapy Regenerative Medice stem cells

New Stem-Cell Based Stroke Treatment Repairs Damaged Brain Tissue

A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research. The research team led by […]

Biotechnology Cell Therapy Clinical Trials stem cells

UCLA Researchers Create Skeletal Muscle From Stem Cells

Discovery is major step towards a stem cell replacement therapy for Duchenne Muscular Dystrophy UCLA scientists have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells, which can produce all cell types of the body. The findings are a major step towards developing a stem […]

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Finding a Key to Unlock Blocked Differentiation in Microrna-Deficient Embryonic Stem Cells

This aids goal to use stem cells in therapy, where an important hurdle is efficient differentiation. The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to […]

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Prostaglandin E1 Inhibits Leukemia Stem Cells Targeting leukemia stem cells in combination with standard chemotherapy may improve treatment for chronic myeloid leukemia

Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice. CML is a relatively common cancer. The American Cancer Society estimates that in 2017 there will be […]

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CRI Scientists Discover Vitamin C Regulates Stem Cell Function and Suppresses Leukemia Development

Not much is known about stem cell metabolism, but a new study from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has found that stem cells take up unusually high levels of vitamin C, which then regulates their function and suppresses the development of leukemia. “We have known for a while that people with […]

Biotechnology Cell Therapy stem cells

Scientists create stem cell therapy for lung fibrosis conditions

A team of scientists from the UNC School of Medicine and North Carolina State University (NCSU) has developed promising research towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis — often-fatal conditions that affect tens of millions of Americans. In […]

Biotechnology cancer Cell Therapy Clinical Trials stem cells

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma

Glioblastoma is the most malignant brain tumor with high mortality. Cancer stem cells are thought to be crucial for tumor initiation and its recurrence after standard therapy with radiation and temozolomide (TMZ) chemotherapy. Protein tyrosine phosphatase receptor type Z (PTPRZ) is an enzyme that is highly expressed in glioblastoma, especially in cancer stem cells. The […]