Alzheimers and Dementia Neurology Neuroscience

Decreased deep sleep linked to early signs of Alzheimer’s disease

 Now, researchers at Washington University School of Medicine in St. Louis may have uncovered part of the explanation. They found that older people who have less slow-wave sleep – the deep sleep you need to consolidate memories and wake up feeling refreshed – have higher levels of the brain protein tau. Elevated tau is a sign of Alzheimer’s disease and has been linked to brain damage and cognitive decline. The
Neurodegenerative diseases Neurology Neuroscience Parkinson's

Researchers Evaluate Controversial Treatment for Parkinson’s Disease Psychosis

 In the wake of media and public reports about increased mortality linked to a new drug for treating Parkinson’s disease psychosis (PDP) — a symptom of the progressive nervous system disorder in which patients experience hallucinations and delusions — researchers at University of California San Diego School of Medicine conducted a retrospective study of qualifying patients in the UC San Diego Health system, concluding that the new drug, pimavanserin (marketed
Neurology Neuroscience

Hypertension Drugs Could Prevent Memory Loss in Lupus Patients, Study Suggests

Researchers from The Feinstein Institute for Medical Research have discovered that the activation of brain cells called microglia likely contributes to the memory loss and other cognitive impairments suffered by many patients with systemic lupus erythematosus (SLE). The study, which will be published September 5 in the Journal of Experimental Medicine, shows that ACE inhibitors—a class of drugs commonly used to treat hypertension—can block this process in mice and might therefore
Neurodegenerative diseases Neurology Neuroscience Parkinson's

Non-Invasive Brain Stimulation May Help Treat Symptoms of Rare Movement Disorders

Electrical stimulation of the brain and spinal cord may help treat the symptoms of rare movement disorders called neurodegenerative ataxias, according to a study published in the August 22, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. There are several types of these disorders, which can be hereditary or occur randomly, including spinocerebellar ataxia, multiple system atrophy and Friedreich’s ataxia. Symptoms of ataxias include a lack
Neurology Neuroscience

Cleveland Clinic Researchers Discover Novel Subtype of Multiple Sclerosis

New findings published in The Lancet Neurology  Cleveland Clinic researchers have discovered a new subtype of multiple sclerosis (MS), providing a better understanding of the individualized nature of the disease. MS has long been characterized as a disease of the brain’s white matter, where immune cells destroy myelin – the fatty protective covering on nerve cells. The destruction of myelin (called demyelination) was believed to be responsible for nerve cell (neuron)
Neuroscience

Microscopic Chariots Deliver Molecules Within Our Cells

On the cellular highway, motor proteins called dyneins rule the road. Dyneins “walk” along structures called microtubules to deliver cellular cargo, such as signaling molecules and organelles, to different parts of a cell. Without dynein on the job, cells cannot divide and people can develop neurological diseases. Now a new study, which appears in the journal Nature Structural & Molecular Biology, provides the first three-dimensional (3D) visualization of the dynein-dynactin complex
Neuroscience Parkinson's

Parkinson’s drug to Treat OFF Episodes Hits Right Notes in Phase 3 Study

Sunovion Pharmaceuticals Inc. announced top line results from its pivotal Phase 3, randomized, double-blind, placebo-controlled clinical trials from its pivotal Phase 3, randomized, double-blind, placebo-controlled clinical trial, CTH-300, that evaluated apomorphine sublingual film (APL-130277) in patients with Parkinson’s disease (PD) who experience motor fluctuations (OFF episodes). Study CTH-300 met its primary and key secondary endpoints, and the medicine was also generally well-tolerated by study participants. Apomorphine sublingual film is being
Neurology Neuroscience

Potential New Autism Drug Shows Promise in Mice

Scientists have performed a successful test of a possible new drug in a mouse model of an autism disorder. The candidate drug, called NitroSynapsin, largely corrected electrical, behavioral and brain abnormalities in the mice. NitroSynapsin is intended to restore an electrical signaling imbalance in the brain found in virtually all forms of autism spectrum disorder (ASD). “This drug candidate is poised to go into clinical trials, and we think it
Biotechnology Neurology Neuroscience Uncategorized

Better ‘Mini Brains’ Could Help Scientists Identify Treatments for Zika-Related Brain Damage

UCLA researchers develop improved technique for creating brain tissue from stem cells UCLA researchers have developed an improved technique for creating simplified human brain tissue from stem cells. Because these so-called “mini brain organoids” mimic human brains in how they grow and develop, they’re vital to studying complex neurological diseases. In a study published in the journal Cell Reports, the researchers used the organoids to better understand how Zika infects and
Biotechnology Neurodegenerative diseases Neurology Neuroscience

Gene Identified That May Provide Potential Therapy for Cerebral Cavernous Malformations

Researchers at University of California San Diego School of Medicine, with national collaborators, have identified a series of molecular clues to understanding the formation of cerebral cavernous malformations (CCMs). The study offers the first genome-wide analysis of the transcriptome of brain microvascular endothelial cells after KRIT1 inactivation. Findings were published September 28 in the Journal of Experimental Medicine. “These mouse studies reveal a critical mechanism in the pathogenesis of cerebral
Neuroscience

Neuroscientists Focus on Cell Mechanism That Promotes Chronic Pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain. The findings, published in the journal PLoS Biology by a UT Dallas neuroscientist and his colleagues, suggest that inhibiting a process called phosphorylation occurring outside of nerve cells might disrupt pain signals, and provide an alternative to opioid drugs for alleviating chronic pain. Dr. Ted Price, the study’s