Biotechnology Cell Therapy Clinical Trials Infectious Diseases

Research with Zebrafish May Lead to Treatment for Blinding Disorders, Including Glaucoma

Jakub Famulski, an assistant professor of biology in the University of Kentucky College of Arts and Sciences, has received a grant for over $1.8 million from the National Institutes of Health to study the early formation of the anterior segment of the eye. The research has the potential to lead to more treatment options for patients with blinding disorders. […]

Biotechnology Infectious Diseases rare diseases

Study Shows Evidence of Severe and Lingering Symptoms in Some after Treatment for Lyme Disease

In a study of 61 people treated for the bacteria that causes Lyme disease, Johns Hopkins researchers conclude that fatigue, pain, insomnia and depression do indeed persist over long periods of time for some people, despite largely normal physical exams and clinical laboratory testing. “Post-treatment Lyme disease syndrome (PTLDS) is a real disorder that causes […]

Biotechnology Gene Therapy Infectious Diseases Vaccines

Discovery of key molecules involved in severe malaria

Malaria*1 is one of three major infectious diseases*2 affecting approximately 300 million people every year, accounting for about 500,000 deaths, but effective vaccine development has not been successful. Among malaria parasites infecting humans, Plasmodium falciparum (P. falciparum)*3 causes especially severe disease. In addition, acquired immunity to malaria is inefficient, even after repeated exposures to P. […]

Biotechnology Cell Therapy Clinical Trials Infectious Diseases stem cells

Finding a Key to Unlock Blocked Differentiation in Microrna-Deficient Embryonic Stem Cells

This aids goal to use stem cells in therapy, where an important hurdle is efficient differentiation. The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to […]

Biotechnology Cell Therapy Clinical Trials Gene Therapy Immunotherapies Infectious Diseases Vaccines

New molecule shows promise in HIV vaccine design

Researchers at the University of Maryland and Duke University have designed a novel protein-sugar vaccine candidate that, in an animal model, stimulated an immune response against sugars that form a protective shield around HIV. The molecule could one day become part of a successful HIV vaccine. “An obstacle to creating an effective HIV vaccine is […]

Biotechnology Immunotherapies Infectious Diseases rare diseases

Good-Guy Bacteria May Help Cancer Immunotherapies Do Their Job

Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic melanoma. The incidence of melanoma has been increasing over the past 40 years. Immunotherapies have dramatically improved the outlook […]

Immunotherapies Infectious Diseases

Confronted with bacteria, infected cells die so others can live, Penn study finds

The immune system is constantly performing surveillance to detect foreign organisms that might do harm. But pathogens, for their part, have evolved a number of strategies to evade this detection, such as secreting proteins that hinder a host’s ability to mount an immune response. In a new study, a team of researchers led by Igor […]

Antibiotics Biotechnology Clinical Trials Immunotherapies Infectious Diseases

Research opens possibility of reducing risk of gut bacterial infections with next-generation probiotic

A team of researchers is exploring the possibility that next-generation probiotics – live bacteria that are good for your health – would reduce the risk of infection with the bacterium Clostridium difficile. In laboratory-grown bacterial communities, the researchers determined that, when supplied with glycerol, the probiotic Lactobacillus reuteri produced reuterin, an antibacterial compound that selectively […]

Biotechnology Cell Therapy Immunotherapies Infectious Diseases

Immune cells may be key to better allergy, infection therapies

By learning how a recently discovered immune cell works in the body, researchers hope to one day harness the cells to better treat allergies and infections, according to new Cornell University research. Type 1 regulatory (Tr1) cells are a type of regulatory immune cell that help suppress immune responses, including inflammation and tissue damage, but […]

Biotechnology Cell Therapy Infectious Diseases

New insights into diagnosing and treating invasive fungal infections will help save lives

Thousands of patients suffering from invasive fungal infections in intensive-care units or after organ transplantation will benefit from the latest insights into diagnostic and therapeutic interventions, published today in the prestigious journal The Lancet Infectious Diseases. Fungal infections invading the bloodstream, lungs or other organs can cause prolonged illness and in extreme cases can lead […]

Biotechnology Infectious Diseases rare diseases

Childhood obesity major link to hip diseases

New research from the University of Liverpool, published in the Archives of Disease in Childhood journal, shows a strong link between childhood obesity and hip diseases in childhood. Significant hip deformities affect around 1 in 500 children. Slipped Capital Femoral Epiphysis (SCFE) is the most common hip disease of adolescence. The condition always requires surgery, […]

Biotechnology Infectious Diseases rare diseases

Researchers Studying Debilitating Lung Disease that Targets Puerto Ricans

Loyola Medicine is enrolling patients in the first major study of a rare, debilitating lung disease that disproportionately affects people from Puerto Rico. The hereditary disease is called Hermansky-Pudlak syndrome (HPS). It can cause bleeding problems, low vision, albinism and in some patients, a debilitating and often fatal lung disease called pulmonary fibrosis, said Loyola […]

Infectious Diseases Laboratory Technology rare diseases

Researchers Develop Mouse That Could Provide Advance Warning of Next Flu Pandemic

Researchers in Germany have developed a transgenic mouse that could help scientists identify new influenza virus strains with the potential to cause a global pandemic. The mouse is described in a study, “In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein,” that will be published April 10 in […]

Antibiotics Cannabinoid Research Infectious Diseases Prodrug

New Arsenal Against MRSA: New Study Reports Cannabinoids Effective Against Antibiotic-Resistant MRSA

Researchers have found that cannabinoid-based therapies have unique anti-bacterial properties that fight MSRA and other infectious bacteria. In vitro studies demonstrated that bactericidal synergy was achieved against multiple species of methicillin-resistant Staphylococcus aureus (MRSA) utilizing a proprietary cannabinoid-based therapeutic platform. MRSA species tested included community acquired- (CA-MRSA), healthcare-acquired- (HA-MRSA), and mupirocin-resistant (MR-MRSA) strains of MRSA. Researchers […]