Heart Health Archives – The Bio Connection

Biotechnology Heart Health Regenerative Medicine

Resolvin D-1 Limits Kidney Damage After Heart Attacks

February 21, 2018 TheBioConnection Comment(0)

A heart attack triggers an acute inflammatory response at the damaged portion of the heart’s left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim — the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a […]

Biotechnology Cell Therapy Clinical Trials Heart Health

Immune Cells Mistake Heart Attacks for Viral Infections

November 7, 2017November 6, 2017 TheBioConnection Comment(0)

A study led by Kevin King, a bioengineer and physician at the University of California San Diego, has found that the immune system plays a surprising role in the aftermath of heart attacks. The research could lead to new therapeutic strategies for heart disease. The team, which also includes researchers from the Center for Systems […]

Biotechnology cancer Cell Therapy Clinical Trials Heart Health

Bariatric surgery lowers cancer risk for severely obese patients

October 9, 2017March 7, 2018 TheBioConnection Comment(0)

Severely obese patients who undergo bariatric surgery lower their risk of developing cancer by at least a third, according to a University of Cincinnati (UC) College of Medicine researcher leading a large retrospective cohort study of patients in the western United States. “We found having bariatric surgery is associated with a reduced risk of cancer, […]

Heart Health Strokes

Study: Breastfeeding Moms May Be at Lower Risk of Heart Attack and Stroke

July 6, 2017July 5, 2017 TheBioConnection Comment(0)

We have known for a long time that breastfeeding is healthy for babies; however studies have shown that it can provide long term health benefits for the moms too. This new information comes from recent research published in the Journal of the American Heart Association. The comprehensive study followed 300,000 adult women in China. Previous […]

'Liquid biopsy' predicts lymphoma therapy success within days August 20, 2018
A blood test can predict which patients with a type of cancer called diffuse large B cell lymphoma are likely to respond positively to initial therapy and which are likely to need more aggressive treatment, according to a multicenter study.
Effect of radiation exposure on hormone deficiencies August 20, 2018
Researchers have detailed the effect of radiation exposure on the development of hormone deficiency in pediatric and young adult patients treated for brain tumors.
STAT3 can be a therapeutic target for chronic active EBV infection, a fatal disorder August 20, 2018
Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppress the survival of these EBV-infected […]
New study explains why genetic mutations cause disease in some people but not in others August 20, 2018
Researchers have uncovered a molecular mechanism behind one of biology's long-standing mysteries: why individuals carrying identical gene mutations for a disease end up having varying severity or symptoms of the disease. The study has exciting implications for future prediction of the severity of serious diseases such as cancer and autism spectrum disorder.
Predictor for immunotherapy response in melanoma August 20, 2018
In a new study, researchers developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors, a novel type of immunotherapy.
Gene therapy vectors carrying the telomerase gene do not increase the risk of cancer August 20, 2018
Researchers have shown in a new study that the gene therapy with telomerase that they have developed, and which has proven to be effective in mice against diseases caused by excessive telomere shortening and ageing, does not cause cancer or increase the risk of developing it, even in a cancer-prone setting.
Nanoparticles in our environment may have more harmful effects than we think August 20, 2018
Researchers warn that a combination of nanoparticles and contaminants may form a cocktail that is harmful to our cells. In their study, 72 pct. of cells died after exposure to a cocktail of nano-silver and cadmium ions.
New drug could prevent debilitating side effect of cancer treatment August 20, 2018
About 50,000 people in the US are diagnosed annually with head, neck, nasal and oral cancers. Most are treated with radiation, and of those, 70-80 percent develop a painful and debilitating side effect called severe oral mucositis. A new drug could potentially prevent the condition.
E-cigarettes can damage DNA August 20, 2018
The popularity of electronic cigarettes continues to grow worldwide, as many people view them as a safer alternative to smoking. But the long-term effects of e-cigarette usage, commonly called 'vaping,' are unknown. Today, researchers report that vaping may modify the genetic material, or DNA, in the oral cells of users, which could increase their cancer […]
A GPS for inside your body August 20, 2018
Scientists have developed a system that can pinpoint the location of ingestible implants inside the body using low-power wireless signals.

FYI Resources developing high purity alumina for growing battery metals sector August 21, 2018
The company aims to revolutionise the HPA production process, eschewing the laborious bauxite-sourced method.
Pharmaxis gains Arix Bioscience Plc as a new substantial shareholder August 20, 2018
Arix led a $24 million share placement and will invest $14.2 million in two tranches.
Small-Cap Snapshot: Shares of generic drugmaker Lannett plunge after losing key customer August 20, 2018
Small cap names on the move today are: Lannett Company Inc (NYSE:LCI), Black Box Corp (NASDAQ:BBOX), Q BioMed Inc (OTCQB:QBIO).
IPO Roundup: Bionano Genomics, Megalith Financial Acquisition and Tenzing Acquisition to tap the capital markets August 20, 2018
Bionano Genomics plans to raise around US$16mln to boost its presence as a life sciences instrumentation company in the genome analysis space
Lannett Co shares crash after losing customer contract as profit warning issued August 20, 2018
A major distribution agreement with Jerome Stevens Pharmaceuticals was not renewed
Q BioMed takes the final step toward FDA approval of its bone pain relief injectable August 20, 2018
The non-narcotic injectable drug is designed to relieve pain in patients with skeletal cancer
Arix Bioscience share sale explains recent market disconnect, say brokers August 20, 2018
Chris Chipperton, a founder of the company, sold 3mln shares or around a third of his stake at 155p
NMC Health shares jump as it issues positive outlook after strong first half August 20, 2018
NMC Health boss Prasanth Manghat said he sees “continuing good growth potential across different parts of the group in 2019 and beyond"
Silence Therapeutics chair Annalisa Jenkins steps down August 20, 2018
Silence Therapeutics said non-executive director Andy Richards has been appointed interim chair
Cannabis stocks in Canada recover after a whirlwind week; Canopy Growth up 8.6% on Friday August 17, 2018
Cannabis stocks stabilized in Canada on Friday after doing significant drops and bumps this week on the back of a host of news in the country that is nearing recreational legalized marijuana in Oct.

STAT Plus: Pharmalittle: Sanofi weighs airlifting flu vaccine post-Brexit; speedy China OK for Roche cancer drug August 20, 2018
Flu vaccine may have to be airlifted into Britain to prevent a winter crisis in the event of a no-deal Brexit, according to the largest producer of the shots.
STAT Plus: Up and down the ladder: The latest comings and goings August 17, 2018
Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot?
STAT Plus: Pharmalittle: Trump wants opioid makers to cut production quotas; Purdue looks to restructure August 17, 2018
Purdue Pharma has hired the Davis Polk & Wardwell law firm for financial restructuring advice.
STAT Plus: Senators challenge Azar over his comments about PBMs and price cuts August 17, 2018
“Congress cannot appropriately fix the problem of high drug prices unless we have correct information about what is causing them and who is responsible.”
STAT Plus: China takes action against numerous officials for allowing vaccine scandal to erupt August 16, 2018
The scandal emerges while the Chinese government is trying to grow its domestic pharmaceutical industry.
STAT Plus: An 8-year-old boy puts Vertex on the defensive over the price of its drugs in the U.K. August 16, 2018
Vertex Pharmaceuticals (VRTX) is facing pushback from cystic fibrosis patients and their families as it plays hardball with the U.K. government over the cost of its medicines. In a highly…
STAT Plus: Pfizer resumes full production at a troubled plant, but don’t expect shortages to suddenly end August 16, 2018
"Things are going to unfortunately be ugly on the drug-shortage front for a long time," said Erin Fox, of the University of Utah Health Care.
STAT Plus: Never mind the rebates. Maybe behind-the-scenes fees are boosting drug prices August 16, 2018
The fees constitute a complicated but little-understood piece of the opaque pricing system.
STAT Plus: Pharmalittle: EpiPen shortage may cause back-to-school crisis; Mylan kept mum about a half-million dollar deal August 16, 2018
Good morning, everyone, and how are you today? We are just fine, thank you, especially since a bright, shiny sun and cool breeze are enveloping the Pharmalot campus. Our short…
STAT Plus: As Gilead plans a C-suite succession, the rash of top-level departures continues August 15, 2018
“Lots of their proteges are sharpening their pencils, updating their resumes, and getting ready to leave.”

Akcea Therapeutics: Ultra-Rare Disease Patients Find Support in Connectedness
Beyond developing novel therapies for serious and rare diseases including FCS, Akcea is also dedicated to supporting the broader needs of the communities they serve.
Bio-Thera Solutions Announces China National Drug Administration Acceptance of Biologics License Application for Proposed Biosimilar to Humira® (Adalimumab)
Bio-Thera Solutions announced that the China National Drug Administration (CNDA) has accepted for review the Biologics License Application (BLA) for BAT1406
FDA Action Alert: Mallinckrodt, Kala Pharma, Merck, Eisai and More
It’s a busy week on the U.S. Food and Drug Administration (FDA)’s calendar, although the agency got ahead of itself and approved three of the applications early. Here’s a look.
Singapore's first clinical trial approval for T cell engineered (TCR) immunotherapy for treatment of Liver cancer
Lion TCR Pte. Ltd., a Singapore-based Biotech company receives approval from Health Sciences Authority (HSA), Singapore, for its Phase I/II multicentre clinical study of its product candidate (LioCyx™) for treatment of relapsed liver cancer post-liver transplantation.
Sensyne Health’s IPO: AI in Healthcare is Hot
Sensyne Health, a London-based healthcare artificial intelligence (AI) company founded by biotech entrepreneur Paul Drayson, recently launched an initial public offering (IPO) on the London AIM market. Drayson’s plan is to raise $78 million. It’s just one of many companies that are exploiting adv...
Harbour BioMed Inks Partnership Deal with Sichuan Kelun-Biotech Worth $350 Million-Plus
Harbour BioMed signed an exclusive strategic partnership deal with Sichuan Kelun-Biotech Biopharmaceutical Co. to develop and commercialize an anti-PD-L1 antibody, A167, currently in Phase II development.
Harbour BioMed Announces Global Strategic Partnership with Kelun-Biotech to Develop and Commercialize A167, An Anti-PD-L1 Antibody, for Treatment of Cancer
Harbour BioMed to develop and commercialize A167 worldwide (excluding Greater China); companies to collaborate on A167 combination therapies
Q BioMed Inc. Announces FDA Filing for Strontium Chloride Sr89 Injection USP for Relief of Metastatic Cancer Bone Pain
Prior Approval Supplement Filing Under GDUFA Guidelines is Final Step in Approval Process
IsoPlexis Announces Expansion into Asia Pacific
IsoPlexis Corporation announced today an exclusive agreement with Tekon Biotech, a leading instrumentation distributor, to distribute IsoPlexis' products in China.
Biotech Movers and Shakers Aug 20
This past week’s roundup of Movers and Shakers in the biotech industry started with a surprise. Gilead Science’s new(ish) chief medical officer was leaving the company six months after taking over the position.