genomic sequencing Archives – The Bio Connection

First Large-Scale Genomic Analysis of Key Acute Leukemia Will Likely Yield New Therapies

July 3, 2017July 10, 2017 TheBioConnection Comment(0)

A consortium including St. Jude Children’s Research Hospital and the Children’s Oncology Group has performed an unprecedented genomic sequencing analysis of hundreds of patients with T-lineage acute lymphoblastic leukemia (T-ALL). The results provide a detailed genomic landscape that will inform treatment strategies and aid efforts to develop drugs to target newly discovered mutations. The data […]

Lymphatic system, key player in human health October 16, 2018
Defects in the lymphatic system have been linked to a wide range of health consequences, but new findings of how the system works could lead to future therapies.
Age-related increase in estrogen may cause common men's hernia October 16, 2018
An age-related increase in estrogen may be the culprit behind inguinal hernias, a condition common among elderly men that often requires corrective surgery. Men could be treated with hormone inhibitor to strengthen muscle, the researcher suggests.
This RNA-based technique could make gene therapy more effective October 16, 2018
Biological engineers have devised a way to regulate the expression of messenger RNA once it gets into cells, giving them more precise control over gene therapy treatments for cancer and other diseases.
A bad influence: Interplay between tumor cells and immune cells October 16, 2018
Research has yielded new insights into the environment surrounding different types of lung tumors, and described how these complex cell ecosystems may in turn ultimately affect response to treatment.
Automated system identifies dense tissue, a risk factor for breast cancer, in mammograms October 16, 2018
Researchers have developed an automated model that assesses dense breast tissue in mammograms -- which is an independent risk factor for breast cancer -- as reliably as expert radiologists. This marks the first time a deep-learning model of its kind has successfully been used in a clinic on real patients, according to the researchers. With […]
Diets rich in fish oil could slow the spread and growth of breast cancer cells October 16, 2018
Omega-3 fatty acids, such as those typically contained in fish oil, may suppress the growth and spread of breast cancer cells in mice.
New way to determine whether metastatic cancer cells in breast cancer patients are dormant or soon to turn deadly October 16, 2018
For the first time ever, researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a recurrence of lethal, metastatic cancer.
Finding better drug 'fits,' avoiding medication tragedies like thalidomide October 15, 2018
Researchers, including chemistry professor and Nobel Prize winner Ei-ichi Negishi, have developed technology to create a new chemical process to synthesize drug-like molecules with ultra-high purity.
3D mammography detected 34 percent more breast cancers in screening October 15, 2018
After screening 15,000 women over a period of five years, a major clinical study in Sweden has shown that 3D mammography, or breast tomosynthesis, detects over 30% more cancers compared to traditional mammography -- with a majority of the detected tumors proving to be invasive cancers.
More clues revealed in link between normal breast changes and invasive breast cancer October 15, 2018
A research team details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

Amryt Pharma’s Lojuxta ‘bad’ cholesterol treatment to be made available in France in early 2019 October 17, 2018
The approval from French regulators means Lojuxta will soon be available in all five of the EU’s largest markets
ValiRx enters final stages of phase I/II trial of its VAL201 prostate cancer drug October 17, 2018
All of the current patients have received the escalated dose, meaning VAL201 is now on the home stretch of the early-stage study
Pot primer: Your guide to legalized cannabis in Canada October 17, 2018
Recreational cannabis is about to be legalized in Canada: We break down the most common questions: Where will it be sold? What are the rules? Where does the country go from here?
MyFiziq body scanner looks to build on Mayweather and McGregor deals October 16, 2018
MyFiziq's (ASX:MYQ) body scanning app hold enormous potential for fitness tracking, online clothing retailers and insurance companies. Clients include Fitocracy, which allows fitness enthusiasts to measure and track their fitness without scales and body fat calipers. Floyd Mayweather's app also uses MyFiziq to allow "Money's" huge social media audience to train and eat the way […]
Enzo Biochem shares slip after posting fiscal fourth-quarter loss of $5.8m October 16, 2018
The company also reported this quarter that it received approval from the New York State Department of Health for an additional three women’s health infectious disease diagnostic assays
CV Sciences partners with the Rodale Institute on organic and industrial hemp research October 16, 2018
The Rodale Institute is one of the country's leading organic farming institutions
Namaste Technologies stock briefly halted due to volatility October 16, 2018
It's been a wild ride for Namaste Technologies in general over the last month and year: the stock has had significant movements
Green Organic Dutchman receives medical sales license from Health Canada October 16, 2018
CEO Brian Athaide said the receipt of the sales license was a 'critical step' in the company's path to becoming a global leading organic cannabis brand
Neovasc shares jump after medical journal publishes favorable article about its Tiara valve October 16, 2018
Not yet commercially approved, the Tiara is a new transcatheter device that treats mitral regurgitation, a severe heart condition
OptiBiotix boss Stephen O’Hara highlights recent direct share purchases in Proactive interview October 16, 2018
“It’s really reassuring to ourselves within OptiBiotix and hopefully to investors that two big industry players…have committed large amounts of money to the company”

STAT Plus: Pharmalittle: Legal issues loom over disclosing prices in TV ads; AstraZeneca halts U.K. investment over Brexit worries October 16, 2018
AstraZeneca has suspended investments in the U.K. due to the lack of clarity over the country's looming departure from the European Union.
STAT Plus: A cost-effectiveness watchdog may charge drug makers for ‘early scientific advice’ October 15, 2018
An ICER spokesman said "we would only do so in a manner that would preserve ICER’s independence and integrity."
STAT Plus: Controversy over a Sanofi dengue vaccine caused a crisis of confidence in the Philippines October 15, 2018
After a recent scandal in the Philippines over a Sanofi dengue vaccine, public confidence in vaccines in general has plummeted in the country, according to a new survey.
STAT Plus: Pharmalittle: Trump to require drug prices in ads; Europe cracks down on valsartan ingredients maker October 15, 2018
Europe cracks down on valsartan ingredients maker in China.
STAT Plus: Merck scraps plans to sell a biosimilar version of Lantus as the insulin market gets crowded October 12, 2018
In an unexpected move, Merck (MRK) scrapped plans to market a biosimilar version of the widely used Lantus insulin only a year after winning tentative U.S. regularly approval. The decision…
STAT Plus: Up and down the ladder: The latest comings and goings October 12, 2018
Hired someone new and exciting? Promoting a rising star? Finally solved that hard-to-fill spot?
STAT Plus: Pharmalittle: FDA approves a record number of generics; Bristol-Myers’ Opdivo fails lung cancer study goal October 12, 2018
As of November, specialist clinicians in the U.K. will be able to prescribe cannabis-derived medicinal products for the first time after a change in the law.
STAT Plus: Industry influence over clinical trial design and reporting lacks transparency October 11, 2018
Few industry-funded trials were conducted completely independently by academics, and sometimes industry involvement was downplayed or omitted.
STAT Plus: Pfizer pays $700,000 to settle charges over misleading copay coupons October 11, 2018
Critics say coupons are, in reality, slick marketing tools used to direct consumers to higher-priced drugs.
STAT Plus: Pharmalittle: Azar promises more action on drug costs; Trump flubs explanation of ‘gag clause’ law October 11, 2018
President Trump finally signed a bill that he says will lower drug prices, but don’t ask him to explain how.

Alkermes to Host Conference Call to Discuss Third Quarter 2018 Financial Results
Alkermes plc will host a conference call and webcast presentation at 8:30 a.m. ET (1:30 p.m. BST) on Tuesday, Oct. 23, 2018, to discuss the company's third quarter 2018 financial results. Management will also provide an update on the company.
eFFECTOR Therapeutics Announces Clinical Collaboration with Merck to Conduct a Phase 2 Combination Trial to Evaluate eFFECTOR's Tomivosertib (eFT508) with KEYTRUDA® (pembrolizumab) for Metastatic Triple Negative Breast Cancer
eFFECTOR Therapeutics, Inc. today announced it has entered into a clinical collaboration agreement with Merck (known as MSD outside the United States and Canada), through a subsidiary, to evaluate the combination of eFFECTOR's tomivosertib (eFT508), an oral, small molecule inhibitor of MNK1/2, with Merck's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab), for the treatment of patients with metastatic […]
Exclusive: 4 Life Science Companies Merge into Discovery Life Sciences
Discovery Life Sciences, a leading research biobank located in Los Osos, California, recently got much, much bigger via a four-company merger. Ann Dover, Discovery’s founder, president and CEO, took time to speak with BioSpace about the merger and the new identity of the company.
BioInvent to Expand Pipeline With New Development Programs in Solid Cancer
Aim is to add three clinical programs in solid cancer starting H1 2019
Listen up! Researchers Find Key to Regrowing Cells Related to Hearing Loss
Among life on earth, mammals are some of the only creatures that can’t regenerate damaged hearing. Birds, frogs, fish, they all have the ability to regenerate sensory hair cells after they’re damaged.
MabVax Therapeutics Audited Financial Statements for 2017 and 2016 Reinstated
MabVax Therapeutics Holdings, Inc. announces today that the Company's audited financial statements for 2017 and 2016 have been re-instated and brought current in quarterly filings with the Securities and Exchange Commission (the "SEC").
Five-Year Data Shows Novartis’ Cosentyx Safe and Effective in Treating Arthritis
New data from an ongoing late-stage study reinforced the safety and efficacy of Cosentyx (secukinumab) as a beneficial treatment for patients with psoriatic arthritis and ankylosing spondylitis.
Amgen Launches AMGEVITA™ (Biosimilar Adalimumab) In Markets Across Europe
First Inflammation Biosimilar From Amgen's Portfolio to Launch in Europe
MERGER CREATES NEW GLOBAL LEADER IN BIOSPECIMEN SOLUTIONS: FOUR COMPANIES UNITE TO FORM DISCOVERY LIFE SCIENCES
Conversant Bio, Folio Bio, Discovery Life Sciences and Phylogeny announced today that they have merged under the name Discovery Life Sciences™ (Discovery) to create a global market leader in biospecimen analysis and procurement for the pharmaceutical, biotechnology and diagnostics industries.
Sanofi, Genentech Both Eye U.S. Expansions; Could Add up to 2,300 Jobs
Two well-established pharma companies are expanding in two different U.S. cities. One city is known for the plethora of pharma and biotech jobs, while the other is in an area that might not immediately spring to mind when it comes to biotech hubs.