Biotechnology Diabetes

Experimental Stem Cell Therapy Speeds Up Wound Healing in Diabetes

The healing of wounded skin in diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows. The research, led by scientists at NYU School of Medicine, focused on a chain of events in diabetes that makes skin sores more likely to form and less likely to heal. Namely, the body's failure in diabetes to break
Biotechnology Diabetes

Key to Weight Loss in 2019: Don’t Diet: Lose Weight!

The South Bronx is notorious for its high obesity and diabetes rates ---the highest in New York State. But Loretta Fleming, as part of a group of community health educators, is fighting this trend with new success. Loretta, herself, was a diabetic who weighed 378 pounds when she took an intensive course in diabetes self-management offered by the South Bronx community group Health People. In three years, she lost 108
Diabetes Heart Health

Diabetes drug could be used to treat common heart failure syndrome, study suggests

Researchers at the University of Arizona have discovered that metformin, a drug commonly used to treat type 2 diabetes, might also be used to treat heart failure with preserved ejection fraction (HFpEF), a condition that is predicted to affect over 8% of people ages 65 or older by the year 2020. The study, which was published December 19 in the Journal of General Physiology, shows that metformin relaxes a key heart muscle protein
Diabetes

Managing High Blood Pressure in Diabetics May Prevent Life-Threatening Organ Damage

The most effective way to prevent life-threatening complications of extreme hypertension in African-Americans with diabetes is to better control their blood pressure, according to a Rutgers study, the largest of its kind. The study, which appears in Clinical and Experimental Hypertension, included 783 diabetic and 1,001 non-diabetic patients from a New Jersey hospital emergency department that serves predominantly African-American communities. It is the first study to look at the risk factors and
Diabetes

Amount of Weight Regain After Bariatric Surgery Helps Predict Health Risks

Measuring the percentage of weight regained following the maximum amount of weight lost after bariatric surgery can help predict a patient’s risk of several serious health problems, according to a long-term, multicenter study led by University of Pittsburgh Graduate School of Public Health researchers. The results, published today in JAMA, also found that, while on average study participants achieved maximum weight loss at two years post-surgery, when they reached that milestone varied substantially,
Biotechnology Cell Therapy Diabetes Pharmaceuticals

Diabetes Drugs Act as Powerful Curb for Immune Cells in Controlling Disease-causing Inflammation

Controlling Immune System Fuel Puts the Brakes on Macrophage Damage When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a common class of drugs used to treat diabetes has been found to exert a powerful
Biotechnology Clinical Trials Diabetes

Experimental Drug Stops Parkinson’s Disease Progression in Mice

Johns Hopkins researchers say they have developed an experimental drug, similar to compounds used to treat diabetes, that slows the progression of Parkinson’s disease itself — as well as its symptoms — in mice. In experiments performed with cultures of human brain cells and live mouse models, they report the drug blocked the degradation of brain cells that is the hallmark of Parkinson’s disease. The drug is expected to move
Diabetes

Platypus venom inspires potential new diabetes treatments

The world-first discovery of a key metabolic hormone found in the venom and gut of Australia’s iconic platypus will now be investigated for its potential to treat type 2 diabetes, in new research led by the University of Adelaide. In a collaboration between the University of Adelaide, Flinders University, Monash University, SAHMRI and the Royal Adelaide Hospital, funding from Medvet Science is supporting a study to investigate whether the platypus
Diabetes

Animal Study Suggests Common Diabetes Drug May Also Help with Nicotine Withdrawal

In a mouse study, a drug that has helped millions of people around the world manage their diabetes might also help people ready to kick their nicotine habits. In a report published this week in The Proceedings of the National Academy of Sciences of the United States of America (PNAS), investigators say metformin, an inexpensive drug commonly used to treat patients with type 2 diabetes, appears to block symptoms of nicotine
Diabetes

Researchers Investigate the Role of Arsenic in the Development of Diabetes

A five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins – found in the human body in 25 different forms – counter the effects of arsenic. Diabetes is a metabolic disease characterized by either a lack of
Biotechnology Diabetes Immunotherapies

Untimely Immune Cell Clocks May Contribute To Obesity And Diabetes In Shift Workers

About 15 million Americans don’t have a typical nine-to-five workday, and many of these—nurses, firefighters and flight attendants, among many other professions—may see their schedule change drastically one week to the next. As a result, these shift workers’ biological clocks, which keep track of the time of day, cannot keep accurate time, potentially making the negative effects of a high fat diet on metabolic disorders even more pronounced, according to new
Diabetes

Genetic discovery may help better identify children at risk for type 1 diabetes

Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it. The TEDDY study's international research team has identified the new gene regions in young people who have already developed type 1 diabetes or who have started making antibodies against their
Diabetes

Pain-Free Skin Patch Responds to Sugar Levels for Management of Type 2 Diabetes

Researchers with NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB) have devised an innovative biochemical formula of mineralized compounds that interacts in the bloodstream to regulate blood sugar for days at a time. In a proof-of-concept study performed with mice, the researchers showed that the biochemically formulated patch of dissolvable microneedles can respond to blood chemistry to manage glucose automatically. “This experimental approach could be a way to take
Diabetes

Kidney Disease Increases Risk of Diabetes, Study Shows Elevated urea levels likely a culprit

Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The nitrogen-containing waste product in blood comes from the breakdown of protein in
Biotechnology Diabetes Pharmaceuticals Prodrug

Targeting a microRNA shows potential to enhance effectiveness of diabetes drugs

Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes. Her latest discovery in this beta-cell pathway, published in the journal Diabetes, shows the potential to enhance the effectiveness of existing diabetes drugs, as well as reduce some of the unwelcome side effects of those drugs. The need for improved treatment is great. Diabetes is a
Diabetes

A step closer to a cure for adult-onset diabetes

In healthy people, exosomes - tiny structures secreted by cells to allow intercellular communication - prevent clumping of the protein that leads to type 2 diabetes. Exosomes in patients with the disease don't have the same ability. This discovery by a research collaboration between Chalmers University of Technology and Astrazeneca takes us a step closer to a cure for type 2 diabetes. Proteins are the body's workhorses, carrying out all
Diabetes

Towards a safe and scalable cell therapy for type 1 diabetes by simplifying beta cell differentiation

More than 36 million people globally are affected by type 1 diabetes (T1D), a lifelong disorder where insulin producing cells are attacked and destroyed by the immune system resulting in deficient insulin production that requires daily blood glucose monitoring and administration of insulin. While successful outcomes from islet transplantations have been reported, very few patients can benefit from this therapeutic option due to limited access to cadaveric donor islets. Human
Biotechnology Diabetes

Higher BMI linked with increased risk of high blood pressure, heart disease, type 2 diabetes

Results of a new study add to the evidence of an association between higher body mass index (BMI) and increased risk of cardiometabolic diseases such as hypertension, coronary heart disease, type 2 diabetes, according to a study published by JAMA Cardiology. A connection between higher BMI and cardiometabolic disease risk usually arise from observational studies that are unable to fully account for confounding by shared risk factors. Mendelian randomization (a
Biotechnology Diabetes

Study reveals sweetened drinks during pregnancy puts infants at higher risk for obesity

A recent Danish study of children born to women with gestational diabetes, found that maternal daily consumption of artificially-sweetened beverages during pregnancy was associated with a higher body mass index score and increased risk of overweight/obesity at 7 years. Artificial sweeteners are widely replacing caloric sweeteners, due to the health concern related to sugar-sweetened beverages (SSBs) within the general population. Artificially sweetened beverages have been considered as potential healthier alternatives,
Clinical Trials Diabetes Prodrug

Diabetes drug prevents stiffening of heart muscle in obese mouse model

Overconsumption of a Western diet high in fats and refined sugars has contributed to a global increase in obesity and Type 2 diabetes. Obese and diabetic premenopausal women are more at risk of developing heart disease -- even more than men of similar age and with similar health issues. A study by researchers at the University of Missouri School of Medicine found that the diabetes medication linagliptin can protect against