Biotechnology cancer Cell Therapy

Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, […]

Biotechnology cancer Cell Therapy Clinical Trials Immunotherapies

Molecular Inhibitors Can Boost Natural Tumor Suppression to Fight Lung Cancer and Mesothelioma

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis. The study, published today in Oncogene, represents significant progress in the clinical translation of previous basic scientific discoveries. “Understanding the molecular features that govern cancer cell behavior is […]

Biotechnology cancer Cell Therapy

Repurposing Existing FDA-Approved Inhibitors May Provide New Treatment Approach for Ovarian Cancer

HDAC inhibitors are effective in treating ovarian tumors with mutations in the ARID1A gene. Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, as a new therapeutic option for ovarian cancer with mutations in the ARID1A […]

Cell Therapy Clinical Trials Dermatology

Targeting Telomeres to Overcome Therapy Resistance in Advanced Melanoma

A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma. The research was published in the journal Clinical Cancer Research. The introduction of targeted therapies and immune checkpoint blockade therapies has revolutionized the therapeutic options […]

Biotechnology Cell Therapy Immunotherapies Uncategorized

Potential new approach to the treatment of multiple sclerosis

A prospective new method of treating patients with multiple sclerosis has been proposed by researchers of the Mainz University Medical Center working in cooperation with researchers of the University of Montreal. In model trials and experiments employing human endothelial cells, they discovered that the EGFL7 protein hinders the migration of immune cells into the central […]

Cell Therapy

Placenta-based Cell Therapy Improves Hematopoietic Transplantation as Reported in Scientific Journal Frontiers in Medicine

Frontiers in Medicine has published key findings from a study of PLX-R18, a cell-based therapy using human placenta, demonstrated the cells’ efficacy in improving human hematopoietic engraftment. The article titled, “Posttransplant Intramuscular Injection of PLX-R18 Mesenchymal-Like Adherent Stromal Cells Improves Human Hematopoietic Engraftment in A Murine Transplant Model” was published in the peer-reviewed journal’s February […]

Biotechnology Cell Therapy Clinical Trials Infectious Diseases

Research with Zebrafish May Lead to Treatment for Blinding Disorders, Including Glaucoma

Jakub Famulski, an assistant professor of biology in the University of Kentucky College of Arts and Sciences, has received a grant for over $1.8 million from the National Institutes of Health to study the early formation of the anterior segment of the eye. The research has the potential to lead to more treatment options for patients with blinding disorders. […]

Biotechnology Cell Therapy Regenerative Medice stem cells

New Stem-Cell Based Stroke Treatment Repairs Damaged Brain Tissue

A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research. The research team led by […]

Biotechnology Cell Therapy Clinical Trials

A Protein Could Make Stem Cell Therapy for Heart Attack Damage More Effective

Researchers may have found a way to reduce ongoing heart damage that occurs long after a severe heart attack by improving the longevity of stem cells injected into the heart. The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the […]

Cell Therapy

Abeona Therapeutics Reports Top-Line Data from Phase 1/2 Gene Therapy Trial in Sanfillippo Syndrome

Abeona Therapeutics Inc., a leading clinical-stage biopharmaceutical company focused on developing novel cell and gene therapies for life-threatening rare genetic diseases, announced updated clinical data from the ongoing Phase 1/2 trial for ABO-102 (AAV-SGSH), the company’s investigational gene therapy for the treatment of Sanfilippo syndrome Type A (MPS IIIA), a rare autosomal-recessive lysosomal storage disease. […]

Biotechnology cancer Cell Therapy Clinical Trials

Short-Course Radiation Treatment Is Safe and Effective for Skin Cancer

A recent Penn State College of Medicine physician’s study review suggests that shorter courses of radiation are preferable to longer ones for older patients receiving treatment for slow-growing skin cancers. Skin basal and squamous cell cancers are common among patients over 60 years old and are rarely fatal. These cancers—which look like moles, freckles or […]

Cell Therapy Clinical Trials Gene Therapy Immunotherapies

Bioengineered Soft Microfibers Improve T-Cell Production

Columbia engineers bioengineer soft microfibers to improve T-cell production. T cells play a key role in the body’s immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based approaches. These “living drugs” are poised to transform medicine, with […]

Biotechnology Cell Therapy Clinical Trials stem cells

UCLA Researchers Create Skeletal Muscle From Stem Cells

Discovery is major step towards a stem cell replacement therapy for Duchenne Muscular Dystrophy UCLA scientists have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells, which can produce all cell types of the body. The findings are a major step towards developing a stem […]

Biotechnology cancer Cell Therapy Clinical Trials

Researchers repurpose immune-activating cytokine to fight breast cancer

The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Sciences, researchers showed triple-negative breast cancer cells are highly vulnerable to interferon-β–a potent antimicrobial that […]

Biotechnology cancer Cell Therapy Immunotherapies Prodrug

2-Drug Combination May Boost Immunotherapy Responses in Lung Cancer Patients

Johns Hopkins Kimmel Cancer Center researchers and colleagues have identified a novel drug combination therapy that could prime nonsmall cell lung cancers to respond better to immunotherapy. These so-called epigenetic therapy drugs, used together, achieved robust anti-tumor responses in human cancer cell lines and mice. During the study, published Nov. 30, 2017, in the journal […]

Biotechnology cancer Cell Therapy Clinical Trials Gene Therapy

Pairing Cancer Genomics with Cognitive Computing Highlights Potential Therapeutic Options

A University of North Carolina Lineberger Comprehensive Cancer Center-led study has demonstrated the ability of cognitive computing to scour large volumes of data from scientific studies and databases to identify potentially relevant clinical trials or therapeutic options for cancer patients based on the genetics of their tumors. The researchers said their findings, published in the […]

Biotechnology Cell Therapy Clinical Trials Infectious Diseases stem cells

Finding a Key to Unlock Blocked Differentiation in Microrna-Deficient Embryonic Stem Cells

This aids goal to use stem cells in therapy, where an important hurdle is efficient differentiation. The more than 200 different types of human cells have the same DNA but express different ensembles of genes. Each cell type was derived from embryonic stem cells, which are called pluripotent stem cells because they can differentiate to […]