cancer Cancer Discovery

Analysis of Prostate Tumors Reveals Clues to Cancer’s Aggressiveness

Sequencing reveals genetic errors common in metastatic tumors Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. The study lays the foundation for finding new ways to treat prostate cancer, particularly for the most aggressive forms of […]

Biotechnology cancer Clinical Trials Uncategorized

Brain metastases common and difficult to treat in ROS1 lung cancer

Increasingly, doctors are treating lung cancer based on the genetic rearrangements driving the disease. For example, cancers that are driven by changes in the genes ALK, EGFR, and ROS1 can now all be paired with drugs that target these specific changes. However, these cancers are not only dangerous in the lung where they appear, but […]

cancer Cancer Discovery

Computer Algorithm Maps Cancer Resistance to Drugs, Therapy

 New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center. The scientists wanted to examine how cancers acquire resistance to treatment over time and whether those changes could be modeled computationally to determine patient-specific timelines of resistance. The research […]

cancer Cancer Discovery

Researchers Find Prostate Cancer Drug Byproduct Can Fuel Cancer Cells

Newly published findings may lead to more personalized prostate cancer therapies A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic. The findings may provide important information for identifying which patients potentially fare better when treated with an […]

cancer Cancer Discovery Immunotherapies

Lethal Prostate Cancer Treatment May Benefit from Combination Immunotherapy

Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy (BKI) released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer. The study suggested a genetic subset of prostate cancer may benefit from this form of immunotherapy. The study […]

cancer Cancer Discovery

Researchers Uncover New Target to Stop Cancer Growth

Researchers at the University of Wisconsin-Madison have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes—tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression. The study, which will be published June 21 in the Journal of Cell Biology, could lead to new therapies that stop tumor growth and metastasis by […]

cancer Cancer Discovery Clinical Trials

Seattle Children’s Opens Immunotherapy Trial For Children With Relapsed Central Nervous System Tumors That Delivers CAR T Cells Directly Into the Brain

CAR T-cell immunotherapy targeting HER2 protein on cancer cells aims to provide children and young adults who have limited treatment options with a second line of defense Seattle Children’s has opened a pioneering chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory HER2-positive central nervous system (CNS) tumors […]

cancer Cancer Discovery

Breast Cancer Could Be Prevented by Targeting Epigenetic Proteins, Study Suggests

Researchers at the Princess Margaret Cancer Centre in Toronto have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study, which will be published June 19 in the Journal of Cell Biology, suggests that inhibiting these proteins with drugs could prevent the development of breast […]

cancer Cancer Discovery

Temple University Scientists Eradicate Cancer Cells Through Dual Targeting of DNA Repair Mechanisms

Proteins commonly known as BRCA – short for BReast CAncer susceptibility gene– serve a critical role in cellular DNA repair, but when mutated they allow genetic errors to replicate, facilitating cancer development. If the BRCA repair system is disabled in cancer cells, the cells simply turn to backup repair mechanisms and adapt to alternative repair […]

cancer Cancer Discovery

Camouflaged Nanoparticles Used to Deliver Killer Protein to Cancer

A team of Penn State researchers has developed a biomimetic nanosystem to deliver therapeutic proteins to selectively target cancerous tumors. Using a protein toxin from a plant found in the Himalayan mountains, called gelonin, the researchers caged the proteins in self-assembled metal-organic framework (MOF) nanoparticles to protect them from the body’s immune system. To enhance […]

cancer Cancer Discovery

Researchers Identify Dozens of New Gene Changes That Point to Elevated Risk of Prostate Cancer in Men of European Descent

 As the result of a six-year long research process, Fredrick R. Schumacher, PhD, a cancer epidemiology researcher at Case Western Reserve University School of Medicine, and an international team of more than 100 colleagues have identified 63 new genetic variations that could indicate higher risk of prostate cancer in men of European descent. The findings, […]

Biotechnology cancer Clinical Trials Prodrug

New Drug Combination Shows Promise in Treating Ovarian Cancer

Researchers at The University of Kansas Cancer Center have discovered a therapy combination that may be helpful in the treatment of certain types of ovarian cancer. Ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system. According to the American Cancer Society, about 22,240 […]

cancer Cancer Discovery

Machine Learning Helps Detect Lymphedema Among Breast Cancer Survivors

Early Detection Using Real-Time Symptom Reports May Help with Timely Treatment  Machine learning using real-time symptom reports can accurately detect lymphedema, a distressing side effect of breast cancer treatment that is more easily treated when identified early, finds a new study led by NYU Rory Meyers College of Nursing and published in the journal mHealth. “Using […]

cancer Cancer Discovery

Mayo Clinic Researchers Take a Step Closer to Developing a DNA Test for Liver Cancer

A group of researchers from Mayo Clinic and Exact Sciences Corporation have completed a phase II study comparing a set of DNA markers to alpha fetoprotein as a method to test for liver cancer. The researchers presented their findings today at the 2018 Digestive Disease Week conference in Washington, D.C. “We currently test for liver cancer using ultrasound and a blood […]

cancer Cancer Discovery Immunotherapies

Checkpoint Inhibitor Shrinks Advanced Squamous Cell Skin Cancer

Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer, an international team led by a researcher at The University of Texas MD Anderson Cancer Center reports in the New England Journal of Medicine. “These results mark a potential paradigm shift in the […]

cancer Cancer Discovery

Landmark Study Finds More Breast Cancer Patients Can Safely Forgo Chemotherapy

A 21-gene test performed on tumors could enable most patients with the most common type of early breast cancer to safely forgo chemotherapy, according to a landmark study published in the New England Journal of Medicine. Loyola Medicine oncologist Kathy Albain, MD, is among the main co-authors of the study and a member of the clinical […]

Biotechnology cancer

Merck’s KEYTRUDA® Demonstrated Long-Term Survival Benefit Based on Four and Five Years of Follow-Up from Two Pivotal Studies in Advanced Melanoma

Merck announced long-term efficacy data from the Phase 3 KEYNOTE-006 study and the melanoma cohort of the Phase 1b KEYNOTE-001 study investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in patients with advanced melanoma. A new analysis from KEYNOTE-006 demonstrated durable efficacy benefits among patients who completed two years of KEYTRUDA treatment, combined with updated overall survival (OS) […]