cancer Cancer Discovery Cancer screening

Investigational Drug Shows Promising Results in Phase II Study of Aggressive, Often Fatal Blood Disorder with No Approved Therapies

A Phase I/II study, led by investigators at The University of Texas MD Anderson Cancer Center, reports an investigational drug called tagraxofusp has demonstrated high response rates in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare but highly aggressive – and often fatal bone marrow and blood disorder – for which there are no […]

cancer Cancer Discovery Cancer screening Immunotherapies

Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study

 A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center. Findings from the study, led by Naval Daver, M.D., associate professor of Leukemia, […]

cancer Cancer Discovery Cancer screening

Spread of Deadly Eye Cancer Halted in Cells and Animals

 By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn’t spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. Their experiments suggest that blocking part of the chain of events — which they successfully accomplished in zebra […]

cancer Cancer Discovery Cancer screening

Combination chemotherapy and immunotherapy effective in Phase II leukemia study

A combination of the standard-of-care chemotherapy drug known as azacitidine, with nivolumab, an immune checkpoint inhibitor, demonstrated an encouraging response rate and overall survival in patients with relapsed or refractory acute myeloid leukemia (AML) according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center. Results from the trial, led by Naval Daver, M.D., associate professor of Leukemia, […]

cancer Cancer Discovery

Dana-Farber Scientists Find New Drug Targets in Aggressive Cancers

 Scientists have discovered a previously unknown molecular vulnerability in two rare, aggressive, and hard-to-treat types of cancer, and say it may be possible to attack this weakness with targeted drugs. Reporting in Nature Cell Biology, researchers at Dana-Farber Cancer Institute show that these two cancers – synovial sarcoma and malignant rhabdoid tumors – are dependent on a […]

cancer Cancer Discovery

Low-Fat Diet Increases Cancer Survival Rate in Mice, Study Finds

Something as simple as a change in diet can potentially help to increase the cancer survival rate of obese children with acute lymphoblastic leukemia, the most common childhood cancer, according to a new study by UCLA scientists. The research team, led by Dr. Steven Mittelman, chief of pediatric endocrinology at UCLA Mattel Children’s Hospital and member of […]

Biotechnology cancer Cell Therapy Immunotherapies rare diseases

Study Uncovers Key Parts of Mechanism for Activating T Cells to Fight Cancer and Other Diseases

In just a few years, CAR T-cell and other adoptive T-cell therapies have emerged as among the most promising forms of cancer immunotherapy. But even as these agents prove themselves against several forms of leukemia and lymphoma – and, potentially, certain solid tumors – basic questions remain about how they work. In a study published […]

cancer Cancer Discovery

Discovery of Pathway Leading to Growth of Colon Cancer Stem Cells Could Lead to New Possibilities in Colorectal Cancer Treatment

In a discovery that may have significant impact on the future of colon cancer treatment and research, scientists at the Helen F. Graham Cancer & Research Institute’s Center for Translational Cancer Research at Christiana Care Health System have defined a key signaling pathway that regulates colon cancer growth. Wilmington, Delaware, Oct. 11, 2018 – In a discovery that may have significant impact on […]

cancer Cancer Discovery Cancer screening

New radiotherapy treatment for brain cancer offers superior preservation of cognitive function, Mayo researchers say

 When it comes to radiation therapy to treat brain cancer, hippocampal-avoidance whole-brain radiotherapy in conjunction with the drug memantine better preserved patients’ cognitive function and demonstrated similar cancer control outcomes, compared to traditional whole-brain radiotherapy with memantine. These findings were presented on Tuesday, Oct. 23, by Mayo Clinic researchers at the 2018 annual meetingof the American Society for Radiation Oncology […]

Biotechnology cancer Clinical Trials

Researchers Use New AI Techniques in Clinical Trials for Personalized Cancer Treatment

Researchers are finding new ways to use artificial intelligence and nanotechnology to enhance treatments, from routine dental techniques to attacking cancerous tissue. At the AVS 65th International Symposium and Exhibition, being held Oct. 21-26, 2018, in Long Beach, California, Dean Ho will present the results of two clinical trials that show how AI-enabled personalized medical […]

cancer Cancer Discovery

Compound Derived From Chinese Tree Bark Shows Promise as Treatment for Pancreatic Cancer

 A new derivative of a compound found in the bark of a rare Chinese tree has powerful anticancer properties and a low toxicity profile, according to researchers at Roswell Park Comprehensive Cancer Center. Results of their study of the effects of the compound F118 in pancreatic cancer were published in the Journal of Experimental & Clinical […]

Breast Cancer cancer Cancer Discovery Cancer screening

Researchers Identify a New Way to Determine Whether Metastatic Cancer Cells in Breast Cancer Patients are Dormant or Soon to Turn Deadly

For the first time ever, Mount Sinai researchers have identified a protein as a marker that can indicate whether a cancer patient will develop a reoccurrence of lethal, metastatic cancer, according to a clinical study published in Breast Cancer Research in October. The researchers found that when cells from a breast cancer patient’s original tumor metastasized into […]

Breast Cancer cancer

Innovative regional anesthesia technique reduces pain, opioid use after mastectomy for breast cancer

Women undergoing mastectomy for breast cancer experience improved postsurgical pain relief and reduced opioid consumption when given a pectoralis nerve plane (PECS) block prior to surgery, suggests research presented at the ANESTHESIOLOGY® 2018 annual meeting. The PECS block is a newer regional anesthesia technique that works by injecting long-acting anesthetics, guided by ultrasound, to numb the front […]

Breast Cancer cancer Cancer Discovery

New Study Shows Promise for Targeting Breast Cancer Metastasis

 A new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as collagen XIII could be key for suppressing breast cancer metastasis. Breast cancers begin in the epithelial cells, which are the cells that line organs and tissues in the body. Generally, most epithelial cells will die after detaching from their […]

cancer Clinical Trials drug development Surgery

Neoadjuvant Combination Checkpoint Blockade Trial Yields High Response Rates for Patients with High-Risk Stage 3 Melanoma

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early. The phase II study was led by researchers at The University of […]

Biotechnology Breast Cancer cancer Cancer Discovery Cancer screening Clinical Trials genes

New Study Finds Nanoparticles Show Promise in Therapy for Triple-Negative Breast Cancer

Approximately 10-20 percent of diagnosed breast cancers are found to be triple-negative, meaning the breast cancer cells test negative for estrogen and progesterone receptors as well as HER2 receptors, genes that can play a role in the development of breast cancer. Triple-negative breast cancer can be more aggressive and difficult to treat as the cancer […]

cancer Cancer Discovery

New Drug Blocks Pancreatic Cancer Growth in Mice, Study Finds

A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a study led by Cedars-Sinai. The study, published recently in the journal Gastroenterology, also demonstrated in mice that the drug, called Metavert, may prevent patients from developing a resistance to currently used pancreatic cancer […]

cancer Cancer Discovery

Queen’s Researchers Discover Ground-Breaking Process Which Destroys Bowel Cancer Cells

Researchers at Queen’s University Belfast have discovered a ground-breaking therapeutic process that can target and kill bowel cancer cells, which may improve survival rates for bowel cancer patients globally. The research, which has been published in the prestigious journal of Molecular Cancer Therapeutics, is deemed the first of its kind with the discovery of a novel treatment […]