Biotechnology cancer Cancer Discovery

Moffitt Cancer Center Researchers Discover Liver Metastases have Different Radiation Sensitivities Based on Primary Tumor Histology

Radiation is a commonly used therapeutic option to treat liver metastases, with the majority of tumors maintained under control after one year. However, some patients do not respond as well to radiation treatment, and the factors that predict patient outcomes are unclear. Moffitt Cancer Center researchers report that liver metastases have different sensitivities to radiation […]

Biotechnology cancer Cancer Discovery Genomes

Spotting Dna Repair Genes Gone Awry

Researchers led by Ludwig Cancer Research scientist Richard Kolodner have developed a new technique for sussing out the genes responsible for helping repair DNA damage that, if left unchecked, can lead to certain cancers. Genome instability suppressing (GIS) genes play an important role in correcting DNA damage involving the improper copying or reshuffling of large […]

Biotechnology cancer Cancer Discovery

University of Pennsylvania to join new collaboration to fight cancer with immunotherapies

The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six of the nation’s top medical schools and cancer centers around a shared aim of accelerating breakthrough immunotherapy research that will turn more cancers into a curable disease. The venture is backed by a $250 million […]

Biomarkers cancer Cancer Discovery

New Study Implicates Unusual Class of Circular RNAs in Cancer

Cancer cells are notorious for their genomes gone haywire, often yielding fusion proteins — mash-ups of two disparate genes that, once united, assume new and harmful capabilities. Exactly how such genome scrambling impacts RNA, particularly the vast and mysterious world of non-coding RNA, has been largely unexplored. Now, a team led by investigators at Beth […]

Cancer Discovery

New Mouse Model for Acute Myeloid Leukemia Opens Door to Research, Possible Treatments

A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets. Scientists from Cincinnati Children’s Hospital Medical Center developed the model and have already used it to gain important new insights into the genetic mechanisms […]