cancer Cancer Discovery

Queen’s Researchers Discover Ground-Breaking Process Which Destroys Bowel Cancer Cells

Researchers at Queen’s University Belfast have discovered a ground-breaking therapeutic process that can target and kill bowel cancer cells, which may improve survival rates for bowel cancer patients globally. The research, which has been published in the prestigious journal of Molecular Cancer Therapeutics, is deemed the first of its kind with the discovery of a novel treatment […]

Cancer Discovery

Eureka Therapeutics Achieves Regression of Metastatic Liver Cancer Using T-Cell Therapy

Eureka Therapeutics, a clinical stage biopharmaceutical company with the goal of curing cancer by developing novel T-cell therapies that harness the evolutionary power of the immune system, announced preliminary safety and clinical results from its ongoing proof-of-concept study of ET140202 T-cell therapy in AFP-positive patients with hepatocellular carcinoma (HCC), the most prevalent form of liver […]

cancer Cancer Discovery

New Test Uncovers Metabolic Vulnerabilities in Kidney Cancer

 In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention. Kidney cancer is one of the […]

cancer Cancer Discovery Immunotherapies

Discovery Could Lead to Higher Response Rates for Bladder Cancer Patients Treated with Immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors. In a study published in August in Nature […]

Breast Cancer cancer Cancer Discovery Clinical Trials

Researchers to Test Novel Drug Combination Against Toughest Breast Cancers

Phase I clinical trial will combine standard chemotherapy with cirmtuzumab, a drug that has shown promise against a variety of cancer types Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or […]

cancer Cancer Discovery

Combination Immunotherapy Shrinks Melanoma Brain Metastases

Combination immunotherapy shrank melanoma that has spread to the brain in more than half of the patients in a clinical trial reported in the New England Journal of Medicine led by an investigator at The University of Texas MD Anderson Cancer Center. Of 94 patients in the single-arm study combining checkpoint inhibitors ipilimumab and nivolumab, at […]

Cancer Discovery

Scientists build a new model of CAR-T cells — Ones with Powerful “Armor” that allow them to fight Solid Tumors

Engineered T-cell therapy, and in particular CAR T-cells, have shown efficacy in CD-19+ blood cancer such as lymphomas and leukemias. However, to date, T-cell therapies have found little success in solid tumors – in part due to the immunosuppressive tumor microenvironment. Checkpoint inhibitors, on the other hand, have been proven effective at empowering the immune […]

cancer Cancer Discovery

Removing the Most Common p53 Mutation in Colorectal Cancer Halts Disease Progression

A Stony Brook pathologist and colleagues publish findings in Cancer Cell By genetically manipulating and removing the most common mutant form of the p53 gene that promotes colorectal cancer in humans, an international team of scientists demonstrated that this therapy reduces tumor growth and tissue invasion. Led by Ute Moll, MD, Professor and cancer biologist in […]

Cancer Discovery

Duke team finds missing immune cells that could fight lethal brain tumor

Glioblastoma brain tumors can have an unusual effect on the body’s immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body’s defenses. Where the T-cells go has been unclear, even as immunotherapies are increasingly employed to stimulate the body’s natural ability to fight invasive tumors. Now researchers […]

cancer Cancer Discovery

Foundation for the National Institutes of Health and Cancer Research Institute Announce New Collaboration in Cancer Immunotherapy

The Foundation for the National Institutes of Health (FNIH) and the Cancer Research Institute (CRI) announced today that FNIH has selected CRI to be its source of landscape intelligence in immuno-oncology, also called cancer immunotherapy. This collaboration draws on CRI’s 65 years of leadership in cancer immunotherapy and its first-in-class immunotherapy landscape analyses produced by […]

cancer Cancer Discovery

“Hijacked” Cell Response to Stress Reveals Promising Drug Targets for Blood Cancer

A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows. The discovery that the NOTCH1 pathway takes control of heat shock transcription factor 1 (HSF1) signaling in T cell acute lymphoblastic leukemia, or […]

cancer Cancer Discovery

Patients with Right-Sided Colon Cancer Have Poorer Survival Rates than Those with Left-Sided Disease

Patients with colorectal cancer tumors on the right side may have poorer five-year survival rates than those whose tumors are located on the left side. However, a new large-scale retrospective study is the first to demonstrate a potential improvement of these outcomes. Study results show that nearly doubling the benchmark number of lymph nodes removed […]

cancer Cancer Discovery

New Study in JNCCN Calls for Continued Aggressive Treatment for Breast Cancer in Women Under 40

By focusing on younger women with breast cancer, researchers were able to shed new light on the risks presented by residual disease for this population, regardless of affected site. A new study from the Stanford Cancer Institutefinds that young women who are treated with chemotherapy for breast cancer but have residual tumor in either the breast or lymph […]

cancer Cancer Discovery

Analysis of Prostate Tumors Reveals Clues to Cancer’s Aggressiveness

Sequencing reveals genetic errors common in metastatic tumors Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. The study lays the foundation for finding new ways to treat prostate cancer, particularly for the most aggressive forms of […]

cancer Cancer Discovery

Computer Algorithm Maps Cancer Resistance to Drugs, Therapy

 New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center. The scientists wanted to examine how cancers acquire resistance to treatment over time and whether those changes could be modeled computationally to determine patient-specific timelines of resistance. The research […]

Cancer Discovery

Poliovirus therapy for recurrent glioblastoma has three year survival rate of 21 percent

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial. Comparatively, just 4 percent of patients at Duke with the same type of recurring brain tumors were alive at three years […]

cancer Cancer Discovery

Researchers Find Prostate Cancer Drug Byproduct Can Fuel Cancer Cells

Newly published findings may lead to more personalized prostate cancer therapies A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic. The findings may provide important information for identifying which patients potentially fare better when treated with an […]

cancer Cancer Discovery Immunotherapies

Lethal Prostate Cancer Treatment May Benefit from Combination Immunotherapy

Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy (BKI) released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer. The study suggested a genetic subset of prostate cancer may benefit from this form of immunotherapy. The study […]