Biotechnology cancer Clinical Trials Prodrug

New Drug Combination Shows Promise in Treating Ovarian Cancer

Researchers at The University of Kansas Cancer Center have discovered a therapy combination that may be helpful in the treatment of certain types of ovarian cancer. Ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system. According to the American Cancer Society, about 22,240 […]

Biotechnology Clinical Trials Pharmaceuticals

A Change in Bacteria’s Genetic Code Holds Promise of Longer-Lasting Drugs

By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs’ effectiveness and convenience, leading to smaller and less frequent doses of medicine, lower health care costs and fewer side effects for patients with […]

Biotechnology cancer

Merck’s KEYTRUDA® Demonstrated Long-Term Survival Benefit Based on Four and Five Years of Follow-Up from Two Pivotal Studies in Advanced Melanoma

Merck announced long-term efficacy data from the Phase 3 KEYNOTE-006 study and the melanoma cohort of the Phase 1b KEYNOTE-001 study investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in patients with advanced melanoma. A new analysis from KEYNOTE-006 demonstrated durable efficacy benefits among patients who completed two years of KEYTRUDA treatment, combined with updated overall survival (OS) […]

Biotechnology

Promise of Faster, More Accessible Schizophrenia Diagnosis, Rutgers Study Shows

A portable device common in optometrists’ offices may hold the key to faster diagnosis of schizophrenia, predicting relapse and symptom severity and assessing treatment effectiveness, a Rutgers University study finds. In the study, published in the May 2018 issue of the Journal of Abnormal Psychology, researchers used RETeval, a hand-held device developed to record electrical activity from […]

Biotechnology

Scientists Develop Method to Tweak Tiny ‘Antenna’ on Cells

Scientists at Johns Hopkins Medicine and the National Tsing Hua University in Taiwan say they have found a fast way to manipulate a cell’s cilia, the tiny, fingerlike protrusions that “feel” and sense their microscopic environment. The experiments, performed in mouse cells, may advance scientists’ efforts to not only understand how the nanosized antennae work, […]

Biotechnology

Untangling Brain Neuron Dysfunction in Parkinson’s Disease and Dementia with Lewy Bodies

A decay of brain function is a hallmark of Parkinson’s disease and dementia with Lewy bodies, or DLB. Specifically, cognitive dysfunction defines DLB, and nearly eight of every 10 Parkinson’s patients develop dementia. In both of these neuro-degenerative diseases, aggregates of misfolded alpha-synuclein protein develop in brain neurons, including the hippocampus, the region of the […]

Biotechnology Cell Therapy Regenerative Medice

Tissue Engineered Human Pancreas Cells Successfully Treat Diabetic Mice

Self-Condensation Process for Cells Generates Vascularized Organ Tissues for Transplant Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a […]

Biotechnology cancer Cell Therapy

Osteoporosis Drug Could Be Used to Treat Aggressive Form of Breast Cancer, Researchers Say

Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. But the study, which will be published May 4 in the Journal of Experimental Medicine, reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents […]

Biotechnology

Rutgers Researchers Help Validate Discovery Method to Identify Antibodies that Target Tumors

The development of targeted tools for therapy is a major focus in oncology.  A new study by investigators at Rutgers Cancer Institute of New Jersey at University Hospital, Rutgers New Jersey Medical School and colleagues from the University of New Mexico Comprehensive Cancer Center and New Mexico-based Specifica, Inc., describes what they call a “major […]

Biotechnology cancer Cell Therapy

FDA Approves CAR T Therapy for Large B-Cell Lymphoma Developed at University of Pennsylvania

The U.S. Food and Drug Administration (FDA) has expanded approval for a personalized cellular therapy developed at the University of Pennsylvania’s Abramson Cancer Center, this time for the treatment of adult patients with relapsed or refractory large B-Cell lymphoma after two or more lines of systemic therapy. Today’s approval includes treatment of diffuse large B-cell […]

Biotechnology cancer Gene Therapy Immunotherapies

CAR-T Immunotherapy Eliminates Metastatic Colorectal Cancer in Mice

Immunotherapy has given patients and oncologists new options, which for some patients, has meant cures for diseases that had been untreatable. Colorectal cancer has a high mortality rate in advanced stages of the disease with few effective therapies. Researchers at the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health show that a type of immunotherapy […]

Biotechnology Cell Therapy

New Cell Therapy Aids Heart Recovery—Without Implanting Cells

Columbia biomedical engineers invent innovative technique to help injured hearts regenerate, through therapeutic application of extracellular vesicles secreted by cardiomyocytes derived from human pluripotent stem cells Heart disease is a major global health problem–myocardial infarction annually affects more than one million people in the U.S. alone, and there is still no effective treatment. The adult […]

Biotechnology Uncategorized

Doctors Prescribe Opioids at High Rates to Those at Increased Overdose Risk, but Trends Improving, Study Finds

Use with anti-anxiety drug benzodiazepine may be linked to rise in opioid-related deaths The number of first-time prescriptions for opioid drugs has not risen since about 2010, according to UCLA researchers. However, patients taking a class of drug known to increase the risk for overdoses were likelier to receive a first-time opioid prescription — a […]

Biotechnology cancer rare diseases

Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2’deoxyguanosine (6-thio-dG) in […]

Biotechnology cancer Uncategorized

When Prostate Cancer Reaches Bone, Bone Cells May Drive Overall Growth of the Disease

When prostate cancer metastasizes to bone, it can become especially dangerous – not only with its action in the bone but, interestingly, with increased aggressiveness of the overall cancer itself. Now, research presented at the American Association for Cancer Research (AACR) Annual Meeting 2018 hints at why: Cells involved in these bone metastases may release […]

Biotechnology cancer Cell Therapy

Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, […]

Biotechnology cancer Cancer Discovery Uncategorized

Identifying a New Therapeutic Target for the Most Common Type of Lung Cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer. Results of the work are being presented as part of a poster session at the American Association […]

Biotechnology cancer Pharmaceuticals Prodrug

New Drug Combo Improves Survival of Women with Rare Uterine Cancer

Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value. […]