Biotechnology cancer rare diseases

Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2’deoxyguanosine (6-thio-dG) in […]

Biotechnology cancer Uncategorized

When Prostate Cancer Reaches Bone, Bone Cells May Drive Overall Growth of the Disease

When prostate cancer metastasizes to bone, it can become especially dangerous – not only with its action in the bone but, interestingly, with increased aggressiveness of the overall cancer itself. Now, research presented at the American Association for Cancer Research (AACR) Annual Meeting 2018 hints at why: Cells involved in these bone metastases may release […]

Biotechnology cancer Cell Therapy

Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, […]

Biotechnology cancer Cancer Discovery Uncategorized

Identifying a New Therapeutic Target for the Most Common Type of Lung Cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer. Results of the work are being presented as part of a poster session at the American Association […]

Biotechnology cancer Pharmaceuticals Prodrug

New Drug Combo Improves Survival of Women with Rare Uterine Cancer

Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value. […]

Biotechnology rare diseases Uncategorized

Study of Mucus May Help Guide Sinusitis Treatment

By April, nearly one-third of the U.S. is already experiencing high pollen levels while the weather and temperatures continue to fluctuate, aggravating sinus symptoms. A patient’s mucus may predict the type of his or her chronic sinusitis, which could help doctors determine whether surgery or medical treatments can produce the best outcomes, according to a […]

Biotechnology cancer Cancer Discovery Medical Devices

New Non-Invasive Test for Urothelial Cancer Emerging

Urothelial cancers of the bladder and upper urinary tract are among the most common cancers encountered worldwide. In the United States, urothelial cancers are among the most costly cancers to treat. With early diagnosis, followed by surgery, most urothelial cancers can be cured. Now an international team of cancer researchers including Kate Dickman, PhD, of the […]

Biotechnology cancer Cell Therapy Clinical Trials Immunotherapies

Molecular Inhibitors Can Boost Natural Tumor Suppression to Fight Lung Cancer and Mesothelioma

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis. The study, published today in Oncogene, represents significant progress in the clinical translation of previous basic scientific discoveries. “Understanding the molecular features that govern cancer cell behavior is […]

Biotechnology Gene Therapy Uncategorized

Gene Therapy May Help Brain Heal From Stroke, Other Injuries

Scientists have found a genetic trigger that may improve the brain’s ability to heal from a range of debilitating conditions, from strokes to concussions and spinal cord injuries. A new study in mice from UT Southwestern’s O’Donnell Brain Institutes hows that turning on a gene inside cells called astrocytes results in a smaller scar and – […]

Biotechnology cancer Cell Therapy

Repurposing Existing FDA-Approved Inhibitors May Provide New Treatment Approach for Ovarian Cancer

HDAC inhibitors are effective in treating ovarian tumors with mutations in the ARID1A gene. Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, as a new therapeutic option for ovarian cancer with mutations in the ARID1A […]

Biotechnology Uncategorized

Chronic Opioids Linked to Increased Complications after Spinal Fusion Surgery

Patients who have been taking opioid pain relievers for several months before spinal fusion surgery are at increased risk of complications after their surgery, reports a study in the journal Spine, published by Wolters Kluwer. Patients on chronic opioid therapy before spinal fusion are at increased risk of complications and adverse outcomes—including repeated spinal surgery, […]

Biotechnology

Testing for Calcium in the Coronary Arteries Provides Better Way to Predict Heart Attack Events than Stress Testing Alone

Researchers at the Intermountain Medical Center Heart Institute in Salt Lake City have found that incorporating underused, but available, imaging technologies, such as PET/CT scans, more precisely predicts who’s at risk for heart attacks and similar threats — in time to prevent them. Researchers measured the level of calcium in the coronary arteries of patients […]

Antibiotics Biotechnology Pharmaceuticals Prescriptions

Link Found Between Pediatric Osteoporosis and Anti-Inflammatory Drugs

By studying mice in late adolescence, Johns Hopkins University researchers have discovered that the rapid bone growth associated with puberty is slowed not only by fewer cartilage cell divisions but also by the “aging” of bone cell precursor cells. After investigating the signaling molecules that promote this transition, the scientists conclude that some weak and […]

Biotechnology Cell Therapy Immunotherapies Uncategorized

Potential new approach to the treatment of multiple sclerosis

A prospective new method of treating patients with multiple sclerosis has been proposed by researchers of the Mainz University Medical Center working in cooperation with researchers of the University of Montreal. In model trials and experiments employing human endothelial cells, they discovered that the EGFL7 protein hinders the migration of immune cells into the central […]

Biotechnology

Multimodal Approach to Pain Management Reduces Opioid Use, Prescriptions After Joint Replacement

A multimodal approach to pain management (using two or more different methods or medications to manage pain) rather than using opioids alone was associated with a decrease in opioid use, opioid prescriptions and common opioid-related complications in patients undergoing total hip or knee replacements, according to a study published today in the Online First edition […]

Biotechnology Clinical Trials Pharmaceuticals Prescriptions Prodrug

IU Research Suggests Failed Osteoarthritis Drug Could Get New Life as Opioid-Addiction Treatment

A new study from Indiana University suggests that a drug proven safe for use in people may prevent opioid tolerance and physical dependence when used in combination with opioid-based pain medications. Researchers in the Linda and Jack Gill Center for Biomolecular Science at IU Bloomington have discovered that a compound previously tested to treat osteoarthritis pain appears […]

Biotechnology

Cell Pouch Regenerative Medicine Clinical Trial for Patients with Type 1 Diabetes Supported with Continuous Glucose Monitoring Systems

Patients undergoing an upcoming Phase I/II single site, single arm clinical trial using Sernova’s signature cell pouch technology, will be provided with a glucose monitoring system from Medtronic Minimed, Northridge, CA. Sernova, a clinical stage company developing regenerative medicine technologies for the treatment of chronic diseases including diabetes and hemophilia, announced continuous glucose monitoring systems […]