Biotechnology

First Mouse Model to Mimic Lung Disease Could Speed Discovery of More Effective Treatments

Penn Study Details Model of Pulmonary Fibrosis, Which Kills More Than 40,000 Each Year The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the […]

Biotechnology

FDA approves first-of-its kind targeted RNA-based therapy to treat a rare disease

The U.S. Food and Drug Administration today approved Onpattro (patisiran) infusion for the treatment of peripheral nerve disease (polyneuropathy) caused by hereditary transthyretin-mediated amyloidosis (hATTR) in adult patients. This is the first FDA-approved treatment for patients with polyneuropathy caused by hATTR, a rare, debilitating and often fatal genetic disease characterized by the buildup of abnormal […]

Biotechnology cancer Neurodegenerative diseases

FDA approves treatment for two rare types of non-Hodgkin lymphoma

The U.S. Food and Drug Administration today approved Poteligeo (mogamulizumab-kpkc) injection for intravenous use for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. This approval provides a new treatment option for patients with MF and is the first FDA approval […]

Biotechnology

NUS and Harvard scientists develop novel drug that could potentially treat liver cancer more effectively

 A research team led by scientists from the Cancer Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma (HCC) or primary liver cancer. This landmark discovery opens door for more effective treatment of liver cancer […]

Biotechnology

Implants Made by Computer-Aided Design Provide Good Results in Patients with Rare Chest Muscle Deformity

For patients with Poland syndrome – a rare cImplants Made by Computer-Aided Design Provide Good Results in Patients with Rare Chest Muscle Deformityongenital condition affecting the chest muscle – computer-aided design (CAD) techniques can be used to create custom-made silicone implants for reconstructive surgery of the chest, reports a paper in the August issue of Plastic and Reconstructive Surgery®, the official medical journal […]

Biotechnology Cell Therapy Diabetes Pharmaceuticals

Diabetes Drugs Act as Powerful Curb for Immune Cells in Controlling Disease-causing Inflammation

Controlling Immune System Fuel Puts the Brakes on Macrophage Damage When tissue is damaged, one of the body’s first inflammatory immune-system responders are macrophages, cells which are commonly thought of as “construction workers” that clear away damaged tissue debris and initiate repair. However, prolonged inflammation promotes the progression of many diseases, including obesity. Now, a […]

Biotechnology

CRISPR/Cas9 gene editing scissors are less accurate than we thought, but there are fixes

by Gaetan Burgio CRISPR gene editing technology is revolutionizing medicine and biology. This technique allows scientists to edit DNA with more precision and greater ease than previous gene editing technology. But a new study has called into question the precision of the technique. The hope for gene editing is that it will be able to […]

Biotechnology Pharmaceuticals rare diseases

Researchers Discover Llama-Derived Nanobody Can Be Used as Potential Therapy for Hard-to-Treat Diseases

Researchers from Case Western Reserve University School of Medicine have found a nanobody that holds promise to advance targeted therapies for a number of neurological diseases and cancer. In a recent study published in Nature Communications, Sahil Gulati, of the Department of Pharmacology at Case Western Reserve School of Medicine, and colleagues identified a nanobody derived […]

Biotechnology Clinical Trials Pharmaceuticals rare diseases

New Insight Into Huntington’s Disease May Open Door to Drug Development

McMaster University researchers have developed a new theory on Huntington’s disease which is being welcomed for showing promise to open new avenues of drug development for the condition. Huntington’s disease is caused by a mutation in the gene that makes the protein called huntingtin. A team of researchers led by McMaster has found there is […]

Biotechnology cancer Clinical Trials Uncategorized

Brain metastases common and difficult to treat in ROS1 lung cancer

Increasingly, doctors are treating lung cancer based on the genetic rearrangements driving the disease. For example, cancers that are driven by changes in the genes ALK, EGFR, and ROS1 can now all be paired with drugs that target these specific changes. However, these cancers are not only dangerous in the lung where they appear, but […]

Biotechnology Clinical Trials Diabetes

Experimental Drug Stops Parkinson’s Disease Progression in Mice

Johns Hopkins researchers say they have developed an experimental drug, similar to compounds used to treat diabetes, that slows the progression of Parkinson’s disease itself — as well as its symptoms — in mice. In experiments performed with cultures of human brain cells and live mouse models, they report the drug blocked the degradation of […]

Biotechnology cancer Clinical Trials Prodrug

New Drug Combination Shows Promise in Treating Ovarian Cancer

Researchers at The University of Kansas Cancer Center have discovered a therapy combination that may be helpful in the treatment of certain types of ovarian cancer. Ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system. According to the American Cancer Society, about 22,240 […]

Biotechnology Clinical Trials Pharmaceuticals

A Change in Bacteria’s Genetic Code Holds Promise of Longer-Lasting Drugs

By altering the genetic code in bacteria, researchers at The University of Texas at Austin have demonstrated a method to make therapeutic proteins more stable, an advance that would improve the drugs’ effectiveness and convenience, leading to smaller and less frequent doses of medicine, lower health care costs and fewer side effects for patients with […]

Biotechnology cancer

Merck’s KEYTRUDA® Demonstrated Long-Term Survival Benefit Based on Four and Five Years of Follow-Up from Two Pivotal Studies in Advanced Melanoma

Merck announced long-term efficacy data from the Phase 3 KEYNOTE-006 study and the melanoma cohort of the Phase 1b KEYNOTE-001 study investigating KEYTRUDA, Merck’s anti-PD-1 therapy, in patients with advanced melanoma. A new analysis from KEYNOTE-006 demonstrated durable efficacy benefits among patients who completed two years of KEYTRUDA treatment, combined with updated overall survival (OS) […]

Biotechnology

Promise of Faster, More Accessible Schizophrenia Diagnosis, Rutgers Study Shows

A portable device common in optometrists’ offices may hold the key to faster diagnosis of schizophrenia, predicting relapse and symptom severity and assessing treatment effectiveness, a Rutgers University study finds. In the study, published in the May 2018 issue of the Journal of Abnormal Psychology, researchers used RETeval, a hand-held device developed to record electrical activity from […]