Biotechnology

New approach could jumpstart breathing after spinal cord injury

 A research team at the Krembil Research Institute in Toronto has developed an innovative strategy that could help to restore breathing following traumatic spinal cord injury. The team, led by principal investigator Dr. Michael Fehlings – a neurosurgeon/neuroscientist, specialist in spinal cord injury and senior scientist at UHN – published its findings today in the […]

Biotechnology

Johns Hopkins Grant Project Looks at Small Cell Lung Cancer Treatment Resistances

 Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation). The National Institutes of Health awarded the grant to researchers from The Johns Hopkins University, co-led by Luigi Marchionni, M.D., Ph.D., assistant professor of […]

Biotechnology Regenerative Medice stem cells

New Technique Uses Umbilical Cord Stem Cells for Early Repair of Cleft Palate

A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.  Performed as part of reconstructive surgery when the infant is a few months old, the stem cell procedure provides good results in growing new bone to close the upper […]

Biotechnology

How the Brain Bounces Back: Mouse Study Reveals that Activity, not Rest, Speeds Recovery After Brain Injury

When recovering from a brain injury, getting back in the swing of things may be more effective than a prolonged period of rest, according to a new Columbia study in mice. These findings offer a compelling example of the brain’s remarkable capacity to adapt in response to trauma. They also point to new, activity-centered treatment […]

Biotechnology

Hopkins Researchers Use Endoscope to Deliver Gene Therapy in Animal Study

Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can’t find their way into the patient’s genomic sequence, they won’t help. Johns Hopkins gastroenterologists Florin Selaru and Vivek Kumbhari believe they’ve taken a major step in the direction of helping patients with certain liver disorders […]

Biotechnology Breast Cancer cancer Cancer Discovery Cancer screening Clinical Trials genes

New Study Finds Nanoparticles Show Promise in Therapy for Triple-Negative Breast Cancer

Approximately 10-20 percent of diagnosed breast cancers are found to be triple-negative, meaning the breast cancer cells test negative for estrogen and progesterone receptors as well as HER2 receptors, genes that can play a role in the development of breast cancer. Triple-negative breast cancer can be more aggressive and difficult to treat as the cancer […]

Biotechnology

A Trojan Horse Delivery of Possible Treatment for a Rare, Potentially Deadly, Blood-Clotting Disorder

In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic enzyme via the cellular equivalent of a Trojan Horse, using tiny blood cell platelets as their protective delivery vehicle, with a key enzyme hidden inside. TTP, or thrombotic thrombocytopenic […]

Biotechnology

Detecting Epigenetic Signature May Help People Stay Ahead of IBD

With an estimated 1.6 million people in the U.S. dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an epigenetic signature in patient cells that appears […]

Biotechnology

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and […]

Biotechnology

CRISPR Screen Identifies Gene That Helps Cells Resist West Nile, Zika Viruses

UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. That nasty class of pathogens includes West Nile virus, dengue fever, Zika virus, and yellow fever. In a study published in Nature Microbiology, the team led by Dr. John Schoggins, Assistant Professor of Microbiology, used […]

Biotechnology Cell Therapy Infectious Diseases rare diseases

Cancer Drug and Antidepressants Provide Clues for Treating Fatal Brain-Eating Amoeba Infections

The amoeba Naegleria fowleri is commonly found in warm swimming pools, lakes and rivers. On rare occasions, the amoeba can infect a healthy person and cause severe primary amebic meningoencephalitis, a “brain-eating” disease that is almost always fatal. Other than trial-and-error with general antifungal medications, there are no treatments for the infection. Researchers at Skaggs […]

Biotechnology Clinical Trials stem cells

Human Neural Stem Cells Drive Spine Regeneration in Rats

Stem cells maintained in culture renewed long regions of spinal cord in rat transplant model NIBIB-funded researchers generated stable lines of spinal cord neural stem cells in a laboratory dish. Once transplanted into a rat model of spinal cord injury, the cells enabled robust regeneration of functional neurons along the length of the spine. The […]

Biotechnology

Robot Helps with Early Screening for Alzheimer’s Patients

September is World Alzheimer’s Awareness Month and a new project in collaboration with UP Health System Portage investigates how technology can assist doctors in earlier diagnosis of the neurodegenerative disease. Alzheimer’s is the most common form of dementia. The US Centers for Disease Control and Prevention reports as many as five million Americans had the […]

Biotechnology Clinical Trials Gene Therapy genes

Proof of Concept Study Aims for Rapid Genotyping to Guide Epilepsy Treatment

An easy and inexpensive test for the HLA-B*15:02 allele could one day allow clinicians to quickly identify which epilepsy patients are at risk of carbamazepine hypersensitivity, according to study results presented by Gita V. Soraya at ILAE’s 2018 Asian & Oceanian Epilepsy Congress in Bali. “This study has provided the proof of principle evidence for […]

Biotechnology

Natural sugar defends against metabolic syndrome, in mice

Trehalose blocks glucose from liver New research, in mice, indicates that a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of […]

Biotechnology

First Mouse Model to Mimic Lung Disease Could Speed Discovery of More Effective Treatments

Penn Study Details Model of Pulmonary Fibrosis, Which Kills More Than 40,000 Each Year The biggest hurdle to finding effective therapies for idiopathic pulmonary fibrosis (IPF) – a life-threatening condition in which the lungs become scarred and breathing is increasingly difficult – has been the inability to fully model the disease in animals, limiting the […]

Biotechnology

FDA approves first-of-its kind targeted RNA-based therapy to treat a rare disease

The U.S. Food and Drug Administration today approved Onpattro (patisiran) infusion for the treatment of peripheral nerve disease (polyneuropathy) caused by hereditary transthyretin-mediated amyloidosis (hATTR) in adult patients. This is the first FDA-approved treatment for patients with polyneuropathy caused by hATTR, a rare, debilitating and often fatal genetic disease characterized by the buildup of abnormal […]

Biotechnology cancer Neurodegenerative diseases

FDA approves treatment for two rare types of non-Hodgkin lymphoma

The U.S. Food and Drug Administration today approved Poteligeo (mogamulizumab-kpkc) injection for intravenous use for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. This approval provides a new treatment option for patients with MF and is the first FDA approval […]