Biotechnology

Promising New Targeted Therapy for Acceleration of Bone Fracture Repair

 There are over six million fractures per year in the U.S. with direct costs in the billions, not to mention lost productivity.  The only drug currently available to accelerate the healing process must be applied directly onto the fracture surface during surgery, but not all breaks require such intervention. New research, Bone Fracture-Targeted Dasatinib Conjugate Potently Enhances Fracture Repair In Vivo, […]

Biotechnology Uncategorized

UCI researchers uncover evidence of restored vision in rats following cell transplant

Researchers from the University of California, Irvine School of Medicine, have discovered that neurons located in the vision centers of the brains of blind rats functioned normally following fetal retina cell transplants, indicating the successful restoration of vision.  The research was published today in JNeurosci, the Journal of Neuroscience. Led by David Lyon, PhD, associate […]

Biotechnology

New Blood Test Identifies Metabolic Subtypes Linked to Autism Spectrum Disorder

NeuroPointDX announced the availability of the NPDX AA test, the first objective blood test that identifies metabolic subtypes associated with autism spectrum disorder in children as young as 18 months old. The NPDX AA test works by detecting amine imbalances in a child’s fasting blood sample with very precise thresholds that were identified and validated based […]

Biotechnology cancer Cell Therapy Immunotherapies rare diseases

Study Uncovers Key Parts of Mechanism for Activating T Cells to Fight Cancer and Other Diseases

In just a few years, CAR T-cell and other adoptive T-cell therapies have emerged as among the most promising forms of cancer immunotherapy. But even as these agents prove themselves against several forms of leukemia and lymphoma – and, potentially, certain solid tumors – basic questions remain about how they work. In a study published […]

Biotechnology

New Penn Medicine Center Brings Immunotherapy Research to Brain Tumor Treatment

Today, Penn Medicine is announcing the newest Translational Center of Excellence (TCE) in the Abramson Cancer Center, focused on Glioblastoma Multiforme, the most common and lethal form of brain cancer. The team will investigate new immune therapies for glioblastoma and, in particular, design and test new CAR T cell therapies. This involves engineering patients’ T […]

Biotechnology

Researchers Ground-Breaking Discovery Finds New Link Between Autoimmune Diseases and a Gut Bacterium

Queen’s University researchers have, for the first time, found a specific microbe in the gut that pumps out protein molecules that mimic a human protein, causing the human defence system to turn on its own cells by mistake. The culprit in this case is called Bacteroides fragilis, a bacterium that normally lives in the human […]

Biotechnology cancer Clinical Trials

Researchers Use New AI Techniques in Clinical Trials for Personalized Cancer Treatment

Researchers are finding new ways to use artificial intelligence and nanotechnology to enhance treatments, from routine dental techniques to attacking cancerous tissue. At the AVS 65th International Symposium and Exhibition, being held Oct. 21-26, 2018, in Long Beach, California, Dean Ho will present the results of two clinical trials that show how AI-enabled personalized medical […]

Biotechnology

New Breakthroughs Offer Hope for Patients with Cystic Fibrosis to Breathe Easier

Two preliminary trials have found that either of two triple-drug regimens could potentially benefit 90 percent of people with cystic fibrosis. The short-term trials found that the drug combinations improved adult patients’ lung function over four weeks. But experts said they were optimistic the results will hold up in the larger, longer-term trials already underway. […]

Biotechnology

New approach could jumpstart breathing after spinal cord injury

 A research team at the Krembil Research Institute in Toronto has developed an innovative strategy that could help to restore breathing following traumatic spinal cord injury. The team, led by principal investigator Dr. Michael Fehlings – a neurosurgeon/neuroscientist, specialist in spinal cord injury and senior scientist at UHN – published its findings today in the […]

Biotechnology

Johns Hopkins Grant Project Looks at Small Cell Lung Cancer Treatment Resistances

 Researchers at the Johns Hopkins Kimmel Cancer Center received a $3.1 million grant to study the resistance of limited stage small cell lung cancer to a combination of chemotherapy and radiotherapy (chemoradiation). The National Institutes of Health awarded the grant to researchers from The Johns Hopkins University, co-led by Luigi Marchionni, M.D., Ph.D., assistant professor of […]

Biotechnology Regenerative Medice stem cells

New Technique Uses Umbilical Cord Stem Cells for Early Repair of Cleft Palate

A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer.  Performed as part of reconstructive surgery when the infant is a few months old, the stem cell procedure provides good results in growing new bone to close the upper […]

Biotechnology

How the Brain Bounces Back: Mouse Study Reveals that Activity, not Rest, Speeds Recovery After Brain Injury

When recovering from a brain injury, getting back in the swing of things may be more effective than a prolonged period of rest, according to a new Columbia study in mice. These findings offer a compelling example of the brain’s remarkable capacity to adapt in response to trauma. They also point to new, activity-centered treatment […]

Biotechnology

Hopkins Researchers Use Endoscope to Deliver Gene Therapy in Animal Study

Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can’t find their way into the patient’s genomic sequence, they won’t help. Johns Hopkins gastroenterologists Florin Selaru and Vivek Kumbhari believe they’ve taken a major step in the direction of helping patients with certain liver disorders […]

Biotechnology Breast Cancer cancer Cancer Discovery Cancer screening Clinical Trials genes

New Study Finds Nanoparticles Show Promise in Therapy for Triple-Negative Breast Cancer

Approximately 10-20 percent of diagnosed breast cancers are found to be triple-negative, meaning the breast cancer cells test negative for estrogen and progesterone receptors as well as HER2 receptors, genes that can play a role in the development of breast cancer. Triple-negative breast cancer can be more aggressive and difficult to treat as the cancer […]

Biotechnology

A Trojan Horse Delivery of Possible Treatment for a Rare, Potentially Deadly, Blood-Clotting Disorder

In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic enzyme via the cellular equivalent of a Trojan Horse, using tiny blood cell platelets as their protective delivery vehicle, with a key enzyme hidden inside. TTP, or thrombotic thrombocytopenic […]

Biotechnology

Detecting Epigenetic Signature May Help People Stay Ahead of IBD

With an estimated 1.6 million people in the U.S. dealing with inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report in the journal JCI Insights finding an epigenetic signature in patient cells that appears […]

Biotechnology

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and […]

Biotechnology

CRISPR Screen Identifies Gene That Helps Cells Resist West Nile, Zika Viruses

UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. That nasty class of pathogens includes West Nile virus, dengue fever, Zika virus, and yellow fever. In a study published in Nature Microbiology, the team led by Dr. John Schoggins, Assistant Professor of Microbiology, used […]

Biotechnology Cell Therapy Infectious Diseases rare diseases

Cancer Drug and Antidepressants Provide Clues for Treating Fatal Brain-Eating Amoeba Infections

The amoeba Naegleria fowleri is commonly found in warm swimming pools, lakes and rivers. On rare occasions, the amoeba can infect a healthy person and cause severe primary amebic meningoencephalitis, a “brain-eating” disease that is almost always fatal. Other than trial-and-error with general antifungal medications, there are no treatments for the infection. Researchers at Skaggs […]